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Fusion gene ID: 26856 |
FusionGeneSummary for PHACTR2_PDZRN4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PHACTR2_PDZRN4 | Fusion gene ID: 26856 | Hgene | Tgene | Gene symbol | PHACTR2 | PDZRN4 | Gene ID | 9749 | 29951 |
| Gene name | phosphatase and actin regulator 2 | PDZ domain containing ring finger 4 | |
| Synonyms | C6orf56 | LNX4|SAMCAP3L | |
| Cytomap | 6q24.2 | 12q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | phosphatase and actin regulator 2 | PDZ domain-containing RING finger protein 4IMAGE5767589SEMACAP3-like proteinligand of Numb protein X 4 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | O75167 | Q6ZMN7 | |
| Ensembl transtripts involved in fusion gene | ENST00000367584, ENST00000427704, ENST00000305766, ENST00000440869, ENST00000367582, ENST00000397980, | ENST00000402685, ENST00000539469, ENST00000298919, | |
| Fusion gene scores | * DoF score | 5 X 5 X 5=125 | 10 X 5 X 7=350 |
| # samples | 8 | 10 | |
| ** MAII score | log2(8/125*10)=-0.643856189774725 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/350*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PHACTR2 [Title/Abstract] AND PDZRN4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW894009 | PHACTR2 | chr6 | 144138108 | - | PDZRN4 | chr12 | 41815052 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000367584 | ENST00000402685 | PHACTR2 | chr6 | 144138108 | - | PDZRN4 | chr12 | 41815052 | - |
| intron-intron | ENST00000367584 | ENST00000539469 | PHACTR2 | chr6 | 144138108 | - | PDZRN4 | chr12 | 41815052 | - |
| intron-intron | ENST00000367584 | ENST00000298919 | PHACTR2 | chr6 | 144138108 | - | PDZRN4 | chr12 | 41815052 | - |
| intron-intron | ENST00000427704 | ENST00000402685 | PHACTR2 | chr6 | 144138108 | - | PDZRN4 | chr12 | 41815052 | - |
| intron-intron | ENST00000427704 | ENST00000539469 | PHACTR2 | chr6 | 144138108 | - | PDZRN4 | chr12 | 41815052 | - |
| intron-intron | ENST00000427704 | ENST00000298919 | PHACTR2 | chr6 | 144138108 | - | PDZRN4 | chr12 | 41815052 | - |
| intron-intron | ENST00000305766 | ENST00000402685 | PHACTR2 | chr6 | 144138108 | - | PDZRN4 | chr12 | 41815052 | - |
| intron-intron | ENST00000305766 | ENST00000539469 | PHACTR2 | chr6 | 144138108 | - | PDZRN4 | chr12 | 41815052 | - |
| intron-intron | ENST00000305766 | ENST00000298919 | PHACTR2 | chr6 | 144138108 | - | PDZRN4 | chr12 | 41815052 | - |
| intron-intron | ENST00000440869 | ENST00000402685 | PHACTR2 | chr6 | 144138108 | - | PDZRN4 | chr12 | 41815052 | - |
| intron-intron | ENST00000440869 | ENST00000539469 | PHACTR2 | chr6 | 144138108 | - | PDZRN4 | chr12 | 41815052 | - |
| intron-intron | ENST00000440869 | ENST00000298919 | PHACTR2 | chr6 | 144138108 | - | PDZRN4 | chr12 | 41815052 | - |
| intron-intron | ENST00000367582 | ENST00000402685 | PHACTR2 | chr6 | 144138108 | - | PDZRN4 | chr12 | 41815052 | - |
| intron-intron | ENST00000367582 | ENST00000539469 | PHACTR2 | chr6 | 144138108 | - | PDZRN4 | chr12 | 41815052 | - |
| intron-intron | ENST00000367582 | ENST00000298919 | PHACTR2 | chr6 | 144138108 | - | PDZRN4 | chr12 | 41815052 | - |
| intron-intron | ENST00000397980 | ENST00000402685 | PHACTR2 | chr6 | 144138108 | - | PDZRN4 | chr12 | 41815052 | - |
| intron-intron | ENST00000397980 | ENST00000539469 | PHACTR2 | chr6 | 144138108 | - | PDZRN4 | chr12 | 41815052 | - |
| intron-intron | ENST00000397980 | ENST00000298919 | PHACTR2 | chr6 | 144138108 | - | PDZRN4 | chr12 | 41815052 | - |
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FusionProtFeatures for PHACTR2_PDZRN4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PHACTR2 | PDZRN4 |