|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 2685 |
FusionGeneSummary for ARID5B_DIS3L2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ARID5B_DIS3L2 | Fusion gene ID: 2685 | Hgene | Tgene | Gene symbol | ARID5B | DIS3L2 | Gene ID | 84159 | 129563 |
| Gene name | AT-rich interaction domain 5B | DIS3 like 3'-5' exoribonuclease 2 | |
| Synonyms | DESRT|MRF-2|MRF2 | FAM6A|PRLMNS|hDIS3L2 | |
| Cytomap | 10q21.2 | 2q37.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | AT-rich interactive domain-containing protein 5BARID domain-containing protein 5BAT-rich interactive domain 5B (MRF1-like)MRF1-like proteinmodulator recognition factor 2 (MRF2) | DIS3-like exonuclease 2DIS3 mitotic control homolog-like 2family with sequence similarity 6, member A | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q14865 | Q8IYB7 | |
| Ensembl transtripts involved in fusion gene | ENST00000279873, ENST00000309334, | ENST00000273009, ENST00000360410, ENST00000325385, ENST00000409401, ENST00000409307, ENST00000470087, | |
| Fusion gene scores | * DoF score | 8 X 8 X 3=192 | 3 X 3 X 2=18 |
| # samples | 8 | 3 | |
| ** MAII score | log2(8/192*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ARID5B [Title/Abstract] AND DIS3L2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ARID5B | GO:0000122 | negative regulation of transcription by RNA polymerase II | 8649988 |
| Hgene | ARID5B | GO:0051091 | positive regulation of DNA binding transcription factor activity | 21532585 |
| Tgene | DIS3L2 | GO:0010587 | miRNA catabolic process | 24141620 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF995991 | ARID5B | chr10 | 63853753 | - | DIS3L2 | chr2 | 233182809 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-intron | ENST00000279873 | ENST00000273009 | ARID5B | chr10 | 63853753 | - | DIS3L2 | chr2 | 233182809 | + |
| 3UTR-intron | ENST00000279873 | ENST00000360410 | ARID5B | chr10 | 63853753 | - | DIS3L2 | chr2 | 233182809 | + |
| 3UTR-intron | ENST00000279873 | ENST00000325385 | ARID5B | chr10 | 63853753 | - | DIS3L2 | chr2 | 233182809 | + |
| 3UTR-intron | ENST00000279873 | ENST00000409401 | ARID5B | chr10 | 63853753 | - | DIS3L2 | chr2 | 233182809 | + |
| 3UTR-intron | ENST00000279873 | ENST00000409307 | ARID5B | chr10 | 63853753 | - | DIS3L2 | chr2 | 233182809 | + |
| 3UTR-intron | ENST00000279873 | ENST00000470087 | ARID5B | chr10 | 63853753 | - | DIS3L2 | chr2 | 233182809 | + |
| intron-intron | ENST00000309334 | ENST00000273009 | ARID5B | chr10 | 63853753 | - | DIS3L2 | chr2 | 233182809 | + |
| intron-intron | ENST00000309334 | ENST00000360410 | ARID5B | chr10 | 63853753 | - | DIS3L2 | chr2 | 233182809 | + |
| intron-intron | ENST00000309334 | ENST00000325385 | ARID5B | chr10 | 63853753 | - | DIS3L2 | chr2 | 233182809 | + |
| intron-intron | ENST00000309334 | ENST00000409401 | ARID5B | chr10 | 63853753 | - | DIS3L2 | chr2 | 233182809 | + |
| intron-intron | ENST00000309334 | ENST00000409307 | ARID5B | chr10 | 63853753 | - | DIS3L2 | chr2 | 233182809 | + |
| intron-intron | ENST00000309334 | ENST00000470087 | ARID5B | chr10 | 63853753 | - | DIS3L2 | chr2 | 233182809 | + |
Top |
FusionProtFeatures for ARID5B_DIS3L2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ARID5B | DIS3L2 |