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Fusion gene ID: 26833 |
FusionGeneSummary for PGM5_CTSL |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PGM5_CTSL | Fusion gene ID: 26833 | Hgene | Tgene | Gene symbol | PGM5 | CTSL | Gene ID | 5239 | 1514 |
| Gene name | phosphoglucomutase 5 | cathepsin L | |
| Synonyms | PGMRP | CATL|CTSL1|MEP | |
| Cytomap | 9q21.11 | 9q21.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | phosphoglucomutase-like protein 5PGM-RPaciculinphosphoglucomutase-related protein | cathepsin L1major excreted protein | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q15124 | P07711 | |
| Ensembl transtripts involved in fusion gene | ENST00000396392, ENST00000396396, ENST00000604870, | ENST00000343150, ENST00000340342, ENST00000495822, ENST00000342020, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 5 X 1=15 |
| # samples | 2 | 6 | |
| ** MAII score | log2(2/1*10)=4.32192809488736 | log2(6/15*10)=2 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PGM5 [Title/Abstract] AND CTSL [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CTSL | GO:0006508 | proteolysis | 8811434|21326229 |
| Tgene | CTSL | GO:0030574 | collagen catabolic process | 22952693 |
| Tgene | CTSL | GO:0051603 | proteolysis involved in cellular protein catabolic process | 22952693 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE836772 | PGM5 | chr9 | 71145625 | - | CTSL | chr9 | 90344595 | - | ||
| ChiTaRS3.1 | BE836763 | PGM5 | chr9 | 71145625 | - | CTSL | chr9 | 90344595 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000396392 | ENST00000343150 | PGM5 | chr9 | 71145625 | - | CTSL | chr9 | 90344595 | - |
| intron-3CDS | ENST00000396392 | ENST00000340342 | PGM5 | chr9 | 71145625 | - | CTSL | chr9 | 90344595 | - |
| intron-3UTR | ENST00000396392 | ENST00000495822 | PGM5 | chr9 | 71145625 | - | CTSL | chr9 | 90344595 | - |
| intron-intron | ENST00000396392 | ENST00000342020 | PGM5 | chr9 | 71145625 | - | CTSL | chr9 | 90344595 | - |
| 3UTR-3CDS | ENST00000396396 | ENST00000343150 | PGM5 | chr9 | 71145625 | - | CTSL | chr9 | 90344595 | - |
| 3UTR-3CDS | ENST00000396396 | ENST00000340342 | PGM5 | chr9 | 71145625 | - | CTSL | chr9 | 90344595 | - |
| 3UTR-3UTR | ENST00000396396 | ENST00000495822 | PGM5 | chr9 | 71145625 | - | CTSL | chr9 | 90344595 | - |
| 3UTR-intron | ENST00000396396 | ENST00000342020 | PGM5 | chr9 | 71145625 | - | CTSL | chr9 | 90344595 | - |
| intron-3CDS | ENST00000604870 | ENST00000343150 | PGM5 | chr9 | 71145625 | - | CTSL | chr9 | 90344595 | - |
| intron-3CDS | ENST00000604870 | ENST00000340342 | PGM5 | chr9 | 71145625 | - | CTSL | chr9 | 90344595 | - |
| intron-3UTR | ENST00000604870 | ENST00000495822 | PGM5 | chr9 | 71145625 | - | CTSL | chr9 | 90344595 | - |
| intron-intron | ENST00000604870 | ENST00000342020 | PGM5 | chr9 | 71145625 | - | CTSL | chr9 | 90344595 | - |
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FusionProtFeatures for PGM5_CTSL |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PGM5 | CTSL |