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Fusion gene ID: 26804 |
FusionGeneSummary for PGD_C11orf24 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PGD_C11orf24 | Fusion gene ID: 26804 | Hgene | Tgene | Gene symbol | PGD | C11orf24 | Gene ID | 26227 | 53838 |
| Gene name | phosphoglycerate dehydrogenase | chromosome 11 open reading frame 24 | |
| Synonyms | 3-PGDH|3PGDH|HEL-S-113|NLS|NLS1|PDG|PGAD|PGD|PGDH|PHGDHD|SERA | DM4E3 | |
| Cytomap | 1p12 | 11q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | D-3-phosphoglycerate dehydrogenase2-oxoglutarate reductase3-phosphoglycerate dehydrogenaseepididymis secretory protein Li 113malate dehydrogenase | uncharacterized protein C11orf24 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P52209 | Q96F05 | |
| Ensembl transtripts involved in fusion gene | ENST00000541529, ENST00000270776, ENST00000538557, ENST00000498356, | ENST00000304271, ENST00000533310, ENST00000530166, | |
| Fusion gene scores | * DoF score | 9 X 6 X 6=324 | 5 X 4 X 4=80 |
| # samples | 10 | 5 | |
| ** MAII score | log2(10/324*10)=-1.6959938131099 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PGD [Title/Abstract] AND C11orf24 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF032755 | PGD | chr1 | 10471601 | + | C11orf24 | chr11 | 68029941 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000541529 | ENST00000304271 | PGD | chr1 | 10471601 | + | C11orf24 | chr11 | 68029941 | - |
| 5CDS-intron | ENST00000541529 | ENST00000533310 | PGD | chr1 | 10471601 | + | C11orf24 | chr11 | 68029941 | - |
| 5CDS-5UTR | ENST00000541529 | ENST00000530166 | PGD | chr1 | 10471601 | + | C11orf24 | chr11 | 68029941 | - |
| Frame-shift | ENST00000270776 | ENST00000304271 | PGD | chr1 | 10471601 | + | C11orf24 | chr11 | 68029941 | - |
| 5CDS-intron | ENST00000270776 | ENST00000533310 | PGD | chr1 | 10471601 | + | C11orf24 | chr11 | 68029941 | - |
| 5CDS-5UTR | ENST00000270776 | ENST00000530166 | PGD | chr1 | 10471601 | + | C11orf24 | chr11 | 68029941 | - |
| Frame-shift | ENST00000538557 | ENST00000304271 | PGD | chr1 | 10471601 | + | C11orf24 | chr11 | 68029941 | - |
| 5CDS-intron | ENST00000538557 | ENST00000533310 | PGD | chr1 | 10471601 | + | C11orf24 | chr11 | 68029941 | - |
| 5CDS-5UTR | ENST00000538557 | ENST00000530166 | PGD | chr1 | 10471601 | + | C11orf24 | chr11 | 68029941 | - |
| intron-3CDS | ENST00000498356 | ENST00000304271 | PGD | chr1 | 10471601 | + | C11orf24 | chr11 | 68029941 | - |
| intron-intron | ENST00000498356 | ENST00000533310 | PGD | chr1 | 10471601 | + | C11orf24 | chr11 | 68029941 | - |
| intron-5UTR | ENST00000498356 | ENST00000530166 | PGD | chr1 | 10471601 | + | C11orf24 | chr11 | 68029941 | - |
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FusionProtFeatures for PGD_C11orf24 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PGD | C11orf24 |