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Fusion gene ID: 26791 |
FusionGeneSummary for PGAP3_PPP1R1B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PGAP3_PPP1R1B | Fusion gene ID: 26791 | Hgene | Tgene | Gene symbol | PGAP3 | PPP1R1B | Gene ID | 93210 | 84152 |
| Gene name | post-GPI attachment to proteins 3 | protein phosphatase 1 regulatory inhibitor subunit 1B | |
| Synonyms | AGLA546|CAB2|PERLD1|PP1498|hCOS16 | DARPP-32|DARPP32 | |
| Cytomap | 17q12 | 17q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | post-GPI attachment to proteins factor 3COS16 homologgene coamplified with ERBB2 proteinper1-like domain containing 1 | protein phosphatase 1 regulatory subunit 1Bdopamine and cAMP-regulated neuronal phosphoprotein 32 | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q96FM1 | Q9UD71 | |
| Ensembl transtripts involved in fusion gene | ENST00000579146, ENST00000300658, ENST00000378011, ENST00000429199, | ENST00000580825, ENST00000254079, ENST00000579000, ENST00000394265, ENST00000394267, | |
| Fusion gene scores | * DoF score | 13 X 4 X 6=312 | 10 X 5 X 11=550 |
| # samples | 12 | 19 | |
| ** MAII score | log2(12/312*10)=-1.37851162325373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(19/550*10)=-1.53343220008107 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PGAP3 [Title/Abstract] AND PPP1R1B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PPP1R1B | GO:0032515 | negative regulation of phosphoprotein phosphatase activity | 10807923 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | STAD | TCGA-D7-8573-01A | PGAP3 | chr17 | 37830870 | - | PPP1R1B | chr17 | 37783559 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000579146 | ENST00000580825 | PGAP3 | chr17 | 37830870 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000579146 | ENST00000254079 | PGAP3 | chr17 | 37830870 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000579146 | ENST00000579000 | PGAP3 | chr17 | 37830870 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-intron | ENST00000579146 | ENST00000394265 | PGAP3 | chr17 | 37830870 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-intron | ENST00000579146 | ENST00000394267 | PGAP3 | chr17 | 37830870 | - | PPP1R1B | chr17 | 37783559 | + |
| 5CDS-5UTR | ENST00000300658 | ENST00000580825 | PGAP3 | chr17 | 37830870 | - | PPP1R1B | chr17 | 37783559 | + |
| 5CDS-5UTR | ENST00000300658 | ENST00000254079 | PGAP3 | chr17 | 37830870 | - | PPP1R1B | chr17 | 37783559 | + |
| 5CDS-5UTR | ENST00000300658 | ENST00000579000 | PGAP3 | chr17 | 37830870 | - | PPP1R1B | chr17 | 37783559 | + |
| 5CDS-intron | ENST00000300658 | ENST00000394265 | PGAP3 | chr17 | 37830870 | - | PPP1R1B | chr17 | 37783559 | + |
| 5CDS-intron | ENST00000300658 | ENST00000394267 | PGAP3 | chr17 | 37830870 | - | PPP1R1B | chr17 | 37783559 | + |
| 5CDS-5UTR | ENST00000378011 | ENST00000580825 | PGAP3 | chr17 | 37830870 | - | PPP1R1B | chr17 | 37783559 | + |
| 5CDS-5UTR | ENST00000378011 | ENST00000254079 | PGAP3 | chr17 | 37830870 | - | PPP1R1B | chr17 | 37783559 | + |
| 5CDS-5UTR | ENST00000378011 | ENST00000579000 | PGAP3 | chr17 | 37830870 | - | PPP1R1B | chr17 | 37783559 | + |
| 5CDS-intron | ENST00000378011 | ENST00000394265 | PGAP3 | chr17 | 37830870 | - | PPP1R1B | chr17 | 37783559 | + |
| 5CDS-intron | ENST00000378011 | ENST00000394267 | PGAP3 | chr17 | 37830870 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000429199 | ENST00000580825 | PGAP3 | chr17 | 37830870 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000429199 | ENST00000254079 | PGAP3 | chr17 | 37830870 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-5UTR | ENST00000429199 | ENST00000579000 | PGAP3 | chr17 | 37830870 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-intron | ENST00000429199 | ENST00000394265 | PGAP3 | chr17 | 37830870 | - | PPP1R1B | chr17 | 37783559 | + |
| intron-intron | ENST00000429199 | ENST00000394267 | PGAP3 | chr17 | 37830870 | - | PPP1R1B | chr17 | 37783559 | + |
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FusionProtFeatures for PGAP3_PPP1R1B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PGAP3 | PPP1R1B |