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Fusion gene ID: 26750 |
FusionGeneSummary for PFKFB3_ASRGL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PFKFB3_ASRGL1 | Fusion gene ID: 26750 | Hgene | Tgene | Gene symbol | PFKFB3 | ASRGL1 | Gene ID | 5209 | 80150 |
| Gene name | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | asparaginase like 1 | |
| Synonyms | IPFK2|PFK2|iPFK-2 | ALP|ALP1|CRASH | |
| Cytomap | 10p15.1 | 11q12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 36-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase6PF-2-K/Fru-2,6-P2ase 36PF-2-K/Fru-2,6-P2ase brain/placenta-type isozymePFK/FBPase 3fructose-6-phosphate,2-kinase/fructose-2, 6-bisphosphatase | isoaspartyl peptidase/L-asparaginaseL-asparaginaseL-asparagine amidohydrolaseasparaginase-like 1 proteinasparaginase-like protein 1beta-aspartyl-peptidaseisoaspartyl dipeptidasetestis secretory sperm-binding protein Li 242mP | |
| Modification date | 20180524 | 20180523 | |
| UniProtAcc | Q16875 | Q7L266 | |
| Ensembl transtripts involved in fusion gene | ENST00000536985, ENST00000379789, ENST00000540253, ENST00000317350, ENST00000379785, ENST00000379782, ENST00000360521, ENST00000379775, | ENST00000415229, ENST00000535727, ENST00000301776, ENST00000528206, | |
| Fusion gene scores | * DoF score | 9 X 8 X 4=288 | 4 X 4 X 2=32 |
| # samples | 9 | 4 | |
| ** MAII score | log2(9/288*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PFKFB3 [Title/Abstract] AND ASRGL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ASRGL1 | GO:0033345 | asparagine catabolic process via L-aspartate | 19839645 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AK025969 | PFKFB3 | chr10 | 6262523 | + | ASRGL1 | chr11 | 62123796 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000536985 | ENST00000415229 | PFKFB3 | chr10 | 6262523 | + | ASRGL1 | chr11 | 62123796 | + |
| intron-intron | ENST00000536985 | ENST00000535727 | PFKFB3 | chr10 | 6262523 | + | ASRGL1 | chr11 | 62123796 | + |
| intron-intron | ENST00000536985 | ENST00000301776 | PFKFB3 | chr10 | 6262523 | + | ASRGL1 | chr11 | 62123796 | + |
| intron-intron | ENST00000536985 | ENST00000528206 | PFKFB3 | chr10 | 6262523 | + | ASRGL1 | chr11 | 62123796 | + |
| intron-3CDS | ENST00000379789 | ENST00000415229 | PFKFB3 | chr10 | 6262523 | + | ASRGL1 | chr11 | 62123796 | + |
| intron-intron | ENST00000379789 | ENST00000535727 | PFKFB3 | chr10 | 6262523 | + | ASRGL1 | chr11 | 62123796 | + |
| intron-intron | ENST00000379789 | ENST00000301776 | PFKFB3 | chr10 | 6262523 | + | ASRGL1 | chr11 | 62123796 | + |
| intron-intron | ENST00000379789 | ENST00000528206 | PFKFB3 | chr10 | 6262523 | + | ASRGL1 | chr11 | 62123796 | + |
| intron-3CDS | ENST00000540253 | ENST00000415229 | PFKFB3 | chr10 | 6262523 | + | ASRGL1 | chr11 | 62123796 | + |
| intron-intron | ENST00000540253 | ENST00000535727 | PFKFB3 | chr10 | 6262523 | + | ASRGL1 | chr11 | 62123796 | + |
| intron-intron | ENST00000540253 | ENST00000301776 | PFKFB3 | chr10 | 6262523 | + | ASRGL1 | chr11 | 62123796 | + |
| intron-intron | ENST00000540253 | ENST00000528206 | PFKFB3 | chr10 | 6262523 | + | ASRGL1 | chr11 | 62123796 | + |
| intron-3CDS | ENST00000317350 | ENST00000415229 | PFKFB3 | chr10 | 6262523 | + | ASRGL1 | chr11 | 62123796 | + |
| intron-intron | ENST00000317350 | ENST00000535727 | PFKFB3 | chr10 | 6262523 | + | ASRGL1 | chr11 | 62123796 | + |
| intron-intron | ENST00000317350 | ENST00000301776 | PFKFB3 | chr10 | 6262523 | + | ASRGL1 | chr11 | 62123796 | + |
| intron-intron | ENST00000317350 | ENST00000528206 | PFKFB3 | chr10 | 6262523 | + | ASRGL1 | chr11 | 62123796 | + |
| intron-3CDS | ENST00000379785 | ENST00000415229 | PFKFB3 | chr10 | 6262523 | + | ASRGL1 | chr11 | 62123796 | + |
| intron-intron | ENST00000379785 | ENST00000535727 | PFKFB3 | chr10 | 6262523 | + | ASRGL1 | chr11 | 62123796 | + |
| intron-intron | ENST00000379785 | ENST00000301776 | PFKFB3 | chr10 | 6262523 | + | ASRGL1 | chr11 | 62123796 | + |
| intron-intron | ENST00000379785 | ENST00000528206 | PFKFB3 | chr10 | 6262523 | + | ASRGL1 | chr11 | 62123796 | + |
| intron-3CDS | ENST00000379782 | ENST00000415229 | PFKFB3 | chr10 | 6262523 | + | ASRGL1 | chr11 | 62123796 | + |
| intron-intron | ENST00000379782 | ENST00000535727 | PFKFB3 | chr10 | 6262523 | + | ASRGL1 | chr11 | 62123796 | + |
| intron-intron | ENST00000379782 | ENST00000301776 | PFKFB3 | chr10 | 6262523 | + | ASRGL1 | chr11 | 62123796 | + |
| intron-intron | ENST00000379782 | ENST00000528206 | PFKFB3 | chr10 | 6262523 | + | ASRGL1 | chr11 | 62123796 | + |
| intron-3CDS | ENST00000360521 | ENST00000415229 | PFKFB3 | chr10 | 6262523 | + | ASRGL1 | chr11 | 62123796 | + |
| intron-intron | ENST00000360521 | ENST00000535727 | PFKFB3 | chr10 | 6262523 | + | ASRGL1 | chr11 | 62123796 | + |
| intron-intron | ENST00000360521 | ENST00000301776 | PFKFB3 | chr10 | 6262523 | + | ASRGL1 | chr11 | 62123796 | + |
| intron-intron | ENST00000360521 | ENST00000528206 | PFKFB3 | chr10 | 6262523 | + | ASRGL1 | chr11 | 62123796 | + |
| intron-3CDS | ENST00000379775 | ENST00000415229 | PFKFB3 | chr10 | 6262523 | + | ASRGL1 | chr11 | 62123796 | + |
| intron-intron | ENST00000379775 | ENST00000535727 | PFKFB3 | chr10 | 6262523 | + | ASRGL1 | chr11 | 62123796 | + |
| intron-intron | ENST00000379775 | ENST00000301776 | PFKFB3 | chr10 | 6262523 | + | ASRGL1 | chr11 | 62123796 | + |
| intron-intron | ENST00000379775 | ENST00000528206 | PFKFB3 | chr10 | 6262523 | + | ASRGL1 | chr11 | 62123796 | + |
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FusionProtFeatures for PFKFB3_ASRGL1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PFKFB3 | ASRGL1 |