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Fusion gene ID: 2675 |
FusionGeneSummary for ARID4B_SCCPDH |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ARID4B_SCCPDH | Fusion gene ID: 2675 | Hgene | Tgene | Gene symbol | ARID4B | SCCPDH | Gene ID | 51742 | 51097 |
| Gene name | AT-rich interaction domain 4B | saccharopine dehydrogenase (putative) | |
| Synonyms | BCAA|BRCAA1|RBBP1L1|RBP1L1|SAP180 | CGI-49|NET11 | |
| Cytomap | 1q42.3 | 1q44 | |
| Type of gene | protein-coding | protein-coding | |
| Description | AT-rich interactive domain-containing protein 4B180 kDa Sin3-associated polypeptideARID domain-containing protein 4BAT rich interactive domain 4B (RBP1-like)Rb-binding protein homologSIN3A-associated protein 180breast cancer-associated antigen 1bre | saccharopine dehydrogenase-like oxidoreductaseprobable saccharopine dehydrogenase | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q4LE39 | Q8NBX0 | |
| Ensembl transtripts involved in fusion gene | ENST00000366603, ENST00000264183, ENST00000349213, ENST00000494543, | ENST00000366510, | |
| Fusion gene scores | * DoF score | 15 X 13 X 7=1365 | 6 X 7 X 3=126 |
| # samples | 16 | 5 | |
| ** MAII score | log2(16/1365*10)=-3.09275714091985 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/126*10)=-1.33342373372519 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ARID4B [Title/Abstract] AND SCCPDH [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-ER-A197-06A | ARID4B | chr1 | 235357328 | - | SCCPDH | chr1 | 246927548 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000366603 | ENST00000366510 | ARID4B | chr1 | 235357328 | - | SCCPDH | chr1 | 246927548 | + |
| Frame-shift | ENST00000264183 | ENST00000366510 | ARID4B | chr1 | 235357328 | - | SCCPDH | chr1 | 246927548 | + |
| Frame-shift | ENST00000349213 | ENST00000366510 | ARID4B | chr1 | 235357328 | - | SCCPDH | chr1 | 246927548 | + |
| intron-3CDS | ENST00000494543 | ENST00000366510 | ARID4B | chr1 | 235357328 | - | SCCPDH | chr1 | 246927548 | + |
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FusionProtFeatures for ARID4B_SCCPDH |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ARID4B | SCCPDH |