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Fusion gene ID: 26701 |
FusionGeneSummary for PEX11B_TPP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PEX11B_TPP1 | Fusion gene ID: 26701 | Hgene | Tgene | Gene symbol | PEX11B | TPP1 | Gene ID | 8799 | 1200 |
| Gene name | peroxisomal biogenesis factor 11 beta | tripeptidyl peptidase 1 | |
| Synonyms | PEX11-BETA|PEX14B | CLN2|GIG1|LPIC|SCAR7|TPP-1 | |
| Cytomap | 1q21.1 | 11p15.4 | |
| Type of gene | protein-coding | protein-coding | |
| Description | peroxisomal membrane protein 11Bperoxin-11Bperoxisomal biogenesis factor 11Bprotein PEX11 homolog beta | tripeptidyl-peptidase 1cell growth-inhibiting gene 1 proteingrowth-inhibiting protein 1lysosomal pepstatin insensitive proteasetripeptidyl aminopeptidasetripeptidyl peptidase I | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O96011 | O14773 | |
| Ensembl transtripts involved in fusion gene | ENST00000369306, ENST00000537888, | ENST00000299427, ENST00000533371, ENST00000534644, ENST00000528657, | |
| Fusion gene scores | * DoF score | 3 X 2 X 2=12 | 7 X 7 X 1=49 |
| # samples | 4 | 9 | |
| ** MAII score | log2(4/12*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/49*10)=0.877143252214467 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PEX11B [Title/Abstract] AND TPP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PEX11B | GO:0007031 | peroxisome organization | 9792670 |
| Hgene | PEX11B | GO:0016559 | peroxisome fission | 9792670|17408615|20826455 |
| Hgene | PEX11B | GO:0044375 | regulation of peroxisome size | 20826455 |
| Hgene | PEX11B | GO:0051260 | protein homooligomerization | 17408615 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF925568 | PEX11B | chr1 | 145523361 | - | TPP1 | chr11 | 6634593 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3UTR | ENST00000369306 | ENST00000299427 | PEX11B | chr1 | 145523361 | - | TPP1 | chr11 | 6634593 | + |
| 3UTR-3UTR | ENST00000369306 | ENST00000533371 | PEX11B | chr1 | 145523361 | - | TPP1 | chr11 | 6634593 | + |
| 3UTR-intron | ENST00000369306 | ENST00000534644 | PEX11B | chr1 | 145523361 | - | TPP1 | chr11 | 6634593 | + |
| 3UTR-intron | ENST00000369306 | ENST00000528657 | PEX11B | chr1 | 145523361 | - | TPP1 | chr11 | 6634593 | + |
| 3UTR-3UTR | ENST00000537888 | ENST00000299427 | PEX11B | chr1 | 145523361 | - | TPP1 | chr11 | 6634593 | + |
| 3UTR-3UTR | ENST00000537888 | ENST00000533371 | PEX11B | chr1 | 145523361 | - | TPP1 | chr11 | 6634593 | + |
| 3UTR-intron | ENST00000537888 | ENST00000534644 | PEX11B | chr1 | 145523361 | - | TPP1 | chr11 | 6634593 | + |
| 3UTR-intron | ENST00000537888 | ENST00000528657 | PEX11B | chr1 | 145523361 | - | TPP1 | chr11 | 6634593 | + |
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FusionProtFeatures for PEX11B_TPP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PEX11B | TPP1 |