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Fusion gene ID: 26603 |
FusionGeneSummary for PDZD2_PDZD2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PDZD2_PDZD2 | Fusion gene ID: 26603 | Hgene | Tgene | Gene symbol | PDZD2 | PDZD2 | Gene ID | 23037 | 23037 |
| Gene name | PDZ domain containing 2 | PDZ domain containing 2 | |
| Synonyms | AIPC|PAPIN|PDZK3|PIN1 | AIPC|PAPIN|PDZK3|PIN1 | |
| Cytomap | 5p13.3 | 5p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | PDZ domain-containing protein 2PDZ domain-containing protein 3activated in prostate cancer proteinplakophilin-related armadillo repeat protein-interactive PDZ protein | PDZ domain-containing protein 2PDZ domain-containing protein 3activated in prostate cancer proteinplakophilin-related armadillo repeat protein-interactive PDZ protein | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | O15018 | O15018 | |
| Ensembl transtripts involved in fusion gene | ENST00000438447, ENST00000282493, ENST00000513490, | ENST00000438447, ENST00000282493, ENST00000513490, | |
| Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 4 X 4 X 2=32 |
| # samples | 5 | 4 | |
| ** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PDZD2 [Title/Abstract] AND PDZD2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW885636 | PDZD2 | chr5 | 31994699 | + | PDZD2 | chr5 | 31993735 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000438447 | ENST00000438447 | PDZD2 | chr5 | 31994699 | + | PDZD2 | chr5 | 31993735 | + |
| intron-intron | ENST00000438447 | ENST00000282493 | PDZD2 | chr5 | 31994699 | + | PDZD2 | chr5 | 31993735 | + |
| intron-intron | ENST00000438447 | ENST00000513490 | PDZD2 | chr5 | 31994699 | + | PDZD2 | chr5 | 31993735 | + |
| intron-intron | ENST00000282493 | ENST00000438447 | PDZD2 | chr5 | 31994699 | + | PDZD2 | chr5 | 31993735 | + |
| intron-intron | ENST00000282493 | ENST00000282493 | PDZD2 | chr5 | 31994699 | + | PDZD2 | chr5 | 31993735 | + |
| intron-intron | ENST00000282493 | ENST00000513490 | PDZD2 | chr5 | 31994699 | + | PDZD2 | chr5 | 31993735 | + |
| intron-intron | ENST00000513490 | ENST00000438447 | PDZD2 | chr5 | 31994699 | + | PDZD2 | chr5 | 31993735 | + |
| intron-intron | ENST00000513490 | ENST00000282493 | PDZD2 | chr5 | 31994699 | + | PDZD2 | chr5 | 31993735 | + |
| intron-intron | ENST00000513490 | ENST00000513490 | PDZD2 | chr5 | 31994699 | + | PDZD2 | chr5 | 31993735 | + |
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FusionProtFeatures for PDZD2_PDZD2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PDZD2 | PDZD2 |