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Fusion gene ID: 26573

FusionGeneSummary for PDSS2_SMARCA4

Fusion gene summary

Fusion gene information	Fusion gene name: PDSS2_SMARCA4
	Fusion gene ID: 26573
		Hgene	Tgene
	Gene symbol	PDSS2	SMARCA4
	Gene ID	57107	6597
	Gene name	decaprenyl diphosphate synthase subunit 2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
	Synonyms	C6orf210\|COQ10D3\|DLP1\|bA59I9.3\|hDLP1	BAF190\|BAF190A\|BRG1\|CSS4\|MRD16\|RTPS2\|SNF2\|SNF2L4\|SNF2LB\|SWI2\|hSNF2b
	Cytomap	6q21	19p13.2
	Type of gene	protein-coding	protein-coding
	Description	decaprenyl-diphosphate synthase subunit 2all-trans-decaprenyl-diphosphate synthase subunit 2decaprenyl pyrophosphate synthase subunit 2decaprenyl pyrophosphate synthetase subunit 2prenyl (decaprenyl) diphosphate synthase, subunit 2subunit 2 of decapr	transcription activator BRG1ATP-dependent helicase SMARCA4BRG1-associated factor 190ABRM/SWI2-related gene 1SNF2-betaSNF2-like 4brahma protein-like 1global transcription activator homologous sequencehomeotic gene regulatormitotic growth and trans
	Modification date	20180527	20180523
	UniProtAcc	Q86YH6	P51532
	Ensembl transtripts involved in fusion gene	ENST00000369037, ENST00000453874, ENST00000369031,	ENST00000358026, ENST00000344626, ENST00000429416, ENST00000541122, ENST00000589677, ENST00000444061, ENST00000590574, ENST00000413806, ENST00000450717, ENST00000538456,
Fusion gene scores	* DoF score	5 X 5 X 3=75	12 X 14 X 8=1344
	# samples	6	15
	** MAII score	log2(6/75*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/1344*10)=-3.16349873228288 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PDSS2 [Title/Abstract] AND SMARCA4 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PDSS2	GO:0006744	ubiquinone biosynthetic process	16262699
Hgene	PDSS2	GO:0008299	isoprenoid biosynthetic process	16262699
Tgene	SMARCA4	GO:0006337	nucleosome disassembly	8895581
Tgene	SMARCA4	GO:0006338	chromatin remodeling	10943845\|11726552
Tgene	SMARCA4	GO:0045892	negative regulation of transcription, DNA-templated	12065415
Tgene	SMARCA4	GO:0045944	positive regulation of transcription by RNA polymerase II	15774904\|17938176
Tgene	SMARCA4	GO:0051091	positive regulation of DNA binding transcription factor activity	11950834\|17938176
Tgene	SMARCA4	GO:1902661	positive regulation of glucose mediated signaling pathway	22368283

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	BRCA	TCGA-BH-A1FE-01A	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094797	+
TCGA	LD	BRCA	TCGA-BH-A1FE-01A	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094800	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000369037	ENST00000358026	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094797	+
5CDS-5UTR	ENST00000369037	ENST00000344626	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094797	+
5CDS-5UTR	ENST00000369037	ENST00000429416	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094797	+
5CDS-5UTR	ENST00000369037	ENST00000541122	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094797	+
5CDS-5UTR	ENST00000369037	ENST00000589677	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094797	+
5CDS-5UTR	ENST00000369037	ENST00000444061	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094797	+
5CDS-5UTR	ENST00000369037	ENST00000590574	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094797	+
5CDS-intron	ENST00000369037	ENST00000413806	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094797	+
5CDS-intron	ENST00000369037	ENST00000450717	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094797	+
5CDS-intron	ENST00000369037	ENST00000538456	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094797	+
5CDS-5UTR	ENST00000453874	ENST00000358026	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094797	+
5CDS-5UTR	ENST00000453874	ENST00000344626	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094797	+
5CDS-5UTR	ENST00000453874	ENST00000429416	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094797	+
5CDS-5UTR	ENST00000453874	ENST00000541122	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094797	+
5CDS-5UTR	ENST00000453874	ENST00000589677	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094797	+
5CDS-5UTR	ENST00000453874	ENST00000444061	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094797	+
5CDS-5UTR	ENST00000453874	ENST00000590574	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094797	+
5CDS-intron	ENST00000453874	ENST00000413806	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094797	+
5CDS-intron	ENST00000453874	ENST00000450717	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094797	+
5CDS-intron	ENST00000453874	ENST00000538456	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094797	+
5CDS-5UTR	ENST00000369031	ENST00000358026	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094797	+
5CDS-5UTR	ENST00000369031	ENST00000344626	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094797	+
5CDS-5UTR	ENST00000369031	ENST00000429416	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094797	+
5CDS-5UTR	ENST00000369031	ENST00000541122	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094797	+
5CDS-5UTR	ENST00000369031	ENST00000589677	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094797	+
5CDS-5UTR	ENST00000369031	ENST00000444061	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094797	+
5CDS-5UTR	ENST00000369031	ENST00000590574	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094797	+
5CDS-intron	ENST00000369031	ENST00000413806	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094797	+
5CDS-intron	ENST00000369031	ENST00000450717	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094797	+
5CDS-intron	ENST00000369031	ENST00000538456	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094797	+
5CDS-5UTR	ENST00000369037	ENST00000358026	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094800	+
5CDS-5UTR	ENST00000369037	ENST00000344626	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094800	+
5CDS-5UTR	ENST00000369037	ENST00000429416	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094800	+
5CDS-5UTR	ENST00000369037	ENST00000541122	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094800	+
5CDS-5UTR	ENST00000369037	ENST00000589677	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094800	+
5CDS-5UTR	ENST00000369037	ENST00000444061	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094800	+
5CDS-5UTR	ENST00000369037	ENST00000590574	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094800	+
5CDS-intron	ENST00000369037	ENST00000413806	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094800	+
5CDS-intron	ENST00000369037	ENST00000450717	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094800	+
5CDS-intron	ENST00000369037	ENST00000538456	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094800	+
5CDS-5UTR	ENST00000453874	ENST00000358026	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094800	+
5CDS-5UTR	ENST00000453874	ENST00000344626	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094800	+
5CDS-5UTR	ENST00000453874	ENST00000429416	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094800	+
5CDS-5UTR	ENST00000453874	ENST00000541122	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094800	+
5CDS-5UTR	ENST00000453874	ENST00000589677	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094800	+
5CDS-5UTR	ENST00000453874	ENST00000444061	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094800	+
5CDS-5UTR	ENST00000453874	ENST00000590574	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094800	+
5CDS-intron	ENST00000453874	ENST00000413806	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094800	+
5CDS-intron	ENST00000453874	ENST00000450717	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094800	+
5CDS-intron	ENST00000453874	ENST00000538456	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094800	+
5CDS-5UTR	ENST00000369031	ENST00000358026	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094800	+
5CDS-5UTR	ENST00000369031	ENST00000344626	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094800	+
5CDS-5UTR	ENST00000369031	ENST00000429416	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094800	+
5CDS-5UTR	ENST00000369031	ENST00000541122	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094800	+
5CDS-5UTR	ENST00000369031	ENST00000589677	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094800	+
5CDS-5UTR	ENST00000369031	ENST00000444061	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094800	+
5CDS-5UTR	ENST00000369031	ENST00000590574	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094800	+
5CDS-intron	ENST00000369031	ENST00000413806	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094800	+
5CDS-intron	ENST00000369031	ENST00000450717	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094800	+
5CDS-intron	ENST00000369031	ENST00000538456	PDSS2	chr6	107780194	-	SMARCA4	chr19	11094800	+

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FusionProtFeatures for PDSS2_SMARCA4

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
PDSS2 Q86YH6	SMARCA4 P51532

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Fusion gene ID: 26573

FusionGeneSummary for PDSS2_SMARCA4

FusionProtFeatures for PDSS2_SMARCA4