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Fusion gene ID: 26536 |
FusionGeneSummary for PDLIM5_SHISA5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PDLIM5_SHISA5 | Fusion gene ID: 26536 | Hgene | Tgene | Gene symbol | PDLIM5 | SHISA5 | Gene ID | 10611 | 51246 |
| Gene name | PDZ and LIM domain 5 | shisa family member 5 | |
| Synonyms | ENH|ENH1|L9|LIM | SCOTIN | |
| Cytomap | 4q22.3 | 3p21.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | PDZ and LIM domain protein 5enigma homologenigma-like LIM domain proteinenigma-like PDZ and LIM domains protein | protein shisa-5putative NF-kappa-B-activating protein 120shisa homolog 5 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q96HC4 | Q8N114 | |
| Ensembl transtripts involved in fusion gene | ENST00000450793, ENST00000538141, ENST00000380180, ENST00000318007, ENST00000437932, ENST00000317968, ENST00000542407, ENST00000508216, ENST00000514743, ENST00000380176, ENST00000359265, ENST00000512274, ENST00000504489, | ENST00000296444, ENST00000444115, ENST00000426002, ENST00000465449, ENST00000442747, ENST00000443308, | |
| Fusion gene scores | * DoF score | 14 X 14 X 6=1176 | 13 X 10 X 7=910 |
| # samples | 15 | 13 | |
| ** MAII score | log2(15/1176*10)=-2.97085365434048 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/910*10)=-2.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PDLIM5 [Title/Abstract] AND SHISA5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-LL-A7T0-01A | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000450793 | ENST00000296444 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-5UTR | ENST00000450793 | ENST00000444115 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-intron | ENST00000450793 | ENST00000426002 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-intron | ENST00000450793 | ENST00000465449 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-5UTR | ENST00000450793 | ENST00000442747 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-5UTR | ENST00000450793 | ENST00000443308 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-3CDS | ENST00000538141 | ENST00000296444 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-5UTR | ENST00000538141 | ENST00000444115 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-intron | ENST00000538141 | ENST00000426002 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-intron | ENST00000538141 | ENST00000465449 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-5UTR | ENST00000538141 | ENST00000442747 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-5UTR | ENST00000538141 | ENST00000443308 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-3CDS | ENST00000380180 | ENST00000296444 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-5UTR | ENST00000380180 | ENST00000444115 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-intron | ENST00000380180 | ENST00000426002 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-intron | ENST00000380180 | ENST00000465449 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-5UTR | ENST00000380180 | ENST00000442747 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-5UTR | ENST00000380180 | ENST00000443308 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-3CDS | ENST00000318007 | ENST00000296444 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-5UTR | ENST00000318007 | ENST00000444115 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-intron | ENST00000318007 | ENST00000426002 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-intron | ENST00000318007 | ENST00000465449 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-5UTR | ENST00000318007 | ENST00000442747 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-5UTR | ENST00000318007 | ENST00000443308 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| In-frame | ENST00000437932 | ENST00000296444 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| 5CDS-5UTR | ENST00000437932 | ENST00000444115 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| 5CDS-intron | ENST00000437932 | ENST00000426002 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| 5CDS-intron | ENST00000437932 | ENST00000465449 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| 5CDS-5UTR | ENST00000437932 | ENST00000442747 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| 5CDS-5UTR | ENST00000437932 | ENST00000443308 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| In-frame | ENST00000317968 | ENST00000296444 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| 5CDS-5UTR | ENST00000317968 | ENST00000444115 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| 5CDS-intron | ENST00000317968 | ENST00000426002 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| 5CDS-intron | ENST00000317968 | ENST00000465449 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| 5CDS-5UTR | ENST00000317968 | ENST00000442747 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| 5CDS-5UTR | ENST00000317968 | ENST00000443308 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| In-frame | ENST00000542407 | ENST00000296444 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| 5CDS-5UTR | ENST00000542407 | ENST00000444115 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| 5CDS-intron | ENST00000542407 | ENST00000426002 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| 5CDS-intron | ENST00000542407 | ENST00000465449 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| 5CDS-5UTR | ENST00000542407 | ENST00000442747 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| 5CDS-5UTR | ENST00000542407 | ENST00000443308 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-3CDS | ENST00000508216 | ENST00000296444 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-5UTR | ENST00000508216 | ENST00000444115 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-intron | ENST00000508216 | ENST00000426002 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-intron | ENST00000508216 | ENST00000465449 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-5UTR | ENST00000508216 | ENST00000442747 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-5UTR | ENST00000508216 | ENST00000443308 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| In-frame | ENST00000514743 | ENST00000296444 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| 5CDS-5UTR | ENST00000514743 | ENST00000444115 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| 5CDS-intron | ENST00000514743 | ENST00000426002 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| 5CDS-intron | ENST00000514743 | ENST00000465449 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| 5CDS-5UTR | ENST00000514743 | ENST00000442747 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| 5CDS-5UTR | ENST00000514743 | ENST00000443308 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| 3UTR-3CDS | ENST00000380176 | ENST00000296444 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| 3UTR-5UTR | ENST00000380176 | ENST00000444115 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| 3UTR-intron | ENST00000380176 | ENST00000426002 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| 3UTR-intron | ENST00000380176 | ENST00000465449 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| 3UTR-5UTR | ENST00000380176 | ENST00000442747 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| 3UTR-5UTR | ENST00000380176 | ENST00000443308 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-3CDS | ENST00000359265 | ENST00000296444 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-5UTR | ENST00000359265 | ENST00000444115 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-intron | ENST00000359265 | ENST00000426002 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-intron | ENST00000359265 | ENST00000465449 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-5UTR | ENST00000359265 | ENST00000442747 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-5UTR | ENST00000359265 | ENST00000443308 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-3CDS | ENST00000512274 | ENST00000296444 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-5UTR | ENST00000512274 | ENST00000444115 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-intron | ENST00000512274 | ENST00000426002 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-intron | ENST00000512274 | ENST00000465449 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-5UTR | ENST00000512274 | ENST00000442747 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-5UTR | ENST00000512274 | ENST00000443308 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-3CDS | ENST00000504489 | ENST00000296444 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-5UTR | ENST00000504489 | ENST00000444115 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-intron | ENST00000504489 | ENST00000426002 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-intron | ENST00000504489 | ENST00000465449 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-5UTR | ENST00000504489 | ENST00000442747 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
| intron-5UTR | ENST00000504489 | ENST00000443308 | PDLIM5 | chr4 | 95539342 | + | SHISA5 | chr3 | 48538726 | - |
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FusionProtFeatures for PDLIM5_SHISA5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PDLIM5 | SHISA5 |