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Fusion gene ID: 26529 |
FusionGeneSummary for PDLIM5_ART3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PDLIM5_ART3 | Fusion gene ID: 26529 | Hgene | Tgene | Gene symbol | PDLIM5 | ART3 | Gene ID | 10611 | 419 |
| Gene name | PDZ and LIM domain 5 | ADP-ribosyltransferase 3 | |
| Synonyms | ENH|ENH1|L9|LIM | ARTC3 | |
| Cytomap | 4q22.3 | 4q21.1|4p15.1-p14 | |
| Type of gene | protein-coding | protein-coding | |
| Description | PDZ and LIM domain protein 5enigma homologenigma-like LIM domain proteinenigma-like PDZ and LIM domains protein | ecto-ADP-ribosyltransferase 3ADP-ribosyltransferase C2 and C3 toxin-like 3NAD(P)(+)--arginine ADP-ribosyltransferase 3mono(ADP-ribosyl)transferase 3mono-ADP-ribosyltransferase | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q96HC4 | Q13508 | |
| Ensembl transtripts involved in fusion gene | ENST00000450793, ENST00000538141, ENST00000380180, ENST00000318007, ENST00000437932, ENST00000317968, ENST00000542407, ENST00000508216, ENST00000514743, ENST00000380176, ENST00000359265, ENST00000512274, ENST00000504489, | ENST00000341029, ENST00000355810, ENST00000349321, ENST00000513494, | |
| Fusion gene scores | * DoF score | 14 X 14 X 6=1176 | 3 X 2 X 3=18 |
| # samples | 15 | 3 | |
| ** MAII score | log2(15/1176*10)=-2.97085365434048 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PDLIM5 [Title/Abstract] AND ART3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-LL-A7T0-01A | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000450793 | ENST00000341029 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-5UTR | ENST00000450793 | ENST00000355810 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-5UTR | ENST00000450793 | ENST00000349321 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-3UTR | ENST00000450793 | ENST00000513494 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-5UTR | ENST00000538141 | ENST00000341029 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-5UTR | ENST00000538141 | ENST00000355810 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-5UTR | ENST00000538141 | ENST00000349321 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-3UTR | ENST00000538141 | ENST00000513494 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-5UTR | ENST00000380180 | ENST00000341029 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-5UTR | ENST00000380180 | ENST00000355810 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-5UTR | ENST00000380180 | ENST00000349321 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-3UTR | ENST00000380180 | ENST00000513494 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-5UTR | ENST00000318007 | ENST00000341029 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-5UTR | ENST00000318007 | ENST00000355810 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-5UTR | ENST00000318007 | ENST00000349321 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-3UTR | ENST00000318007 | ENST00000513494 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-5UTR | ENST00000437932 | ENST00000341029 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-5UTR | ENST00000437932 | ENST00000355810 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-5UTR | ENST00000437932 | ENST00000349321 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-3UTR | ENST00000437932 | ENST00000513494 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-5UTR | ENST00000317968 | ENST00000341029 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-5UTR | ENST00000317968 | ENST00000355810 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-5UTR | ENST00000317968 | ENST00000349321 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-3UTR | ENST00000317968 | ENST00000513494 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5UTR-5UTR | ENST00000542407 | ENST00000341029 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5UTR-5UTR | ENST00000542407 | ENST00000355810 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5UTR-5UTR | ENST00000542407 | ENST00000349321 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5UTR-3UTR | ENST00000542407 | ENST00000513494 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-5UTR | ENST00000508216 | ENST00000341029 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-5UTR | ENST00000508216 | ENST00000355810 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-5UTR | ENST00000508216 | ENST00000349321 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-3UTR | ENST00000508216 | ENST00000513494 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-5UTR | ENST00000514743 | ENST00000341029 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-5UTR | ENST00000514743 | ENST00000355810 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-5UTR | ENST00000514743 | ENST00000349321 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-3UTR | ENST00000514743 | ENST00000513494 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| intron-5UTR | ENST00000380176 | ENST00000341029 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| intron-5UTR | ENST00000380176 | ENST00000355810 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| intron-5UTR | ENST00000380176 | ENST00000349321 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| intron-3UTR | ENST00000380176 | ENST00000513494 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-5UTR | ENST00000359265 | ENST00000341029 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-5UTR | ENST00000359265 | ENST00000355810 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-5UTR | ENST00000359265 | ENST00000349321 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-3UTR | ENST00000359265 | ENST00000513494 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-5UTR | ENST00000512274 | ENST00000341029 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-5UTR | ENST00000512274 | ENST00000355810 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-5UTR | ENST00000512274 | ENST00000349321 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-3UTR | ENST00000512274 | ENST00000513494 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-5UTR | ENST00000504489 | ENST00000341029 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-5UTR | ENST00000504489 | ENST00000355810 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-5UTR | ENST00000504489 | ENST00000349321 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
| 5CDS-3UTR | ENST00000504489 | ENST00000513494 | PDLIM5 | chr4 | 95376535 | + | ART3 | chr4 | 76997034 | + |
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FusionProtFeatures for PDLIM5_ART3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PDLIM5 | ART3 |