|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 26528 |
FusionGeneSummary for PDLIM3_ZFYVE28 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PDLIM3_ZFYVE28 | Fusion gene ID: 26528 | Hgene | Tgene | Gene symbol | PDLIM3 | ZFYVE28 | Gene ID | 27295 | 57732 |
| Gene name | PDZ and LIM domain 3 | zinc finger FYVE-type containing 28 | |
| Synonyms | ALP | LST2|LYST2 | |
| Cytomap | 4q35.1 | 4p16.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | PDZ and LIM domain protein 3alpha-actinin-2-associated LIM proteinenigma homolog | lateral signaling target protein 2 homologhLst2zinc finger FYVE domain-containing protein 28zinc finger, FYVE domain containing 28 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q53GG5 | Q9HCC9 | |
| Ensembl transtripts involved in fusion gene | ENST00000284770, ENST00000284771, ENST00000284767, | ENST00000290974, ENST00000511071, ENST00000515312, ENST00000515169, ENST00000509171, ENST00000503000, ENST00000508471, ENST00000505421, | |
| Fusion gene scores | * DoF score | 4 X 2 X 4=32 | 8 X 6 X 7=336 |
| # samples | 4 | 8 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(8/336*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PDLIM3 [Title/Abstract] AND ZFYVE28 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LGG | TCGA-DH-A669-01A | PDLIM3 | chr4 | 186456496 | - | ZFYVE28 | chr4 | 2355800 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000284770 | ENST00000290974 | PDLIM3 | chr4 | 186456496 | - | ZFYVE28 | chr4 | 2355800 | - |
| In-frame | ENST00000284770 | ENST00000511071 | PDLIM3 | chr4 | 186456496 | - | ZFYVE28 | chr4 | 2355800 | - |
| 5CDS-5UTR | ENST00000284770 | ENST00000515312 | PDLIM3 | chr4 | 186456496 | - | ZFYVE28 | chr4 | 2355800 | - |
| 5CDS-5UTR | ENST00000284770 | ENST00000515169 | PDLIM3 | chr4 | 186456496 | - | ZFYVE28 | chr4 | 2355800 | - |
| 5CDS-intron | ENST00000284770 | ENST00000509171 | PDLIM3 | chr4 | 186456496 | - | ZFYVE28 | chr4 | 2355800 | - |
| 5CDS-intron | ENST00000284770 | ENST00000503000 | PDLIM3 | chr4 | 186456496 | - | ZFYVE28 | chr4 | 2355800 | - |
| 5CDS-intron | ENST00000284770 | ENST00000508471 | PDLIM3 | chr4 | 186456496 | - | ZFYVE28 | chr4 | 2355800 | - |
| 5CDS-intron | ENST00000284770 | ENST00000505421 | PDLIM3 | chr4 | 186456496 | - | ZFYVE28 | chr4 | 2355800 | - |
| In-frame | ENST00000284771 | ENST00000290974 | PDLIM3 | chr4 | 186456496 | - | ZFYVE28 | chr4 | 2355800 | - |
| In-frame | ENST00000284771 | ENST00000511071 | PDLIM3 | chr4 | 186456496 | - | ZFYVE28 | chr4 | 2355800 | - |
| 5CDS-5UTR | ENST00000284771 | ENST00000515312 | PDLIM3 | chr4 | 186456496 | - | ZFYVE28 | chr4 | 2355800 | - |
| 5CDS-5UTR | ENST00000284771 | ENST00000515169 | PDLIM3 | chr4 | 186456496 | - | ZFYVE28 | chr4 | 2355800 | - |
| 5CDS-intron | ENST00000284771 | ENST00000509171 | PDLIM3 | chr4 | 186456496 | - | ZFYVE28 | chr4 | 2355800 | - |
| 5CDS-intron | ENST00000284771 | ENST00000503000 | PDLIM3 | chr4 | 186456496 | - | ZFYVE28 | chr4 | 2355800 | - |
| 5CDS-intron | ENST00000284771 | ENST00000508471 | PDLIM3 | chr4 | 186456496 | - | ZFYVE28 | chr4 | 2355800 | - |
| 5CDS-intron | ENST00000284771 | ENST00000505421 | PDLIM3 | chr4 | 186456496 | - | ZFYVE28 | chr4 | 2355800 | - |
| In-frame | ENST00000284767 | ENST00000290974 | PDLIM3 | chr4 | 186456496 | - | ZFYVE28 | chr4 | 2355800 | - |
| In-frame | ENST00000284767 | ENST00000511071 | PDLIM3 | chr4 | 186456496 | - | ZFYVE28 | chr4 | 2355800 | - |
| 5CDS-5UTR | ENST00000284767 | ENST00000515312 | PDLIM3 | chr4 | 186456496 | - | ZFYVE28 | chr4 | 2355800 | - |
| 5CDS-5UTR | ENST00000284767 | ENST00000515169 | PDLIM3 | chr4 | 186456496 | - | ZFYVE28 | chr4 | 2355800 | - |
| 5CDS-intron | ENST00000284767 | ENST00000509171 | PDLIM3 | chr4 | 186456496 | - | ZFYVE28 | chr4 | 2355800 | - |
| 5CDS-intron | ENST00000284767 | ENST00000503000 | PDLIM3 | chr4 | 186456496 | - | ZFYVE28 | chr4 | 2355800 | - |
| 5CDS-intron | ENST00000284767 | ENST00000508471 | PDLIM3 | chr4 | 186456496 | - | ZFYVE28 | chr4 | 2355800 | - |
| 5CDS-intron | ENST00000284767 | ENST00000505421 | PDLIM3 | chr4 | 186456496 | - | ZFYVE28 | chr4 | 2355800 | - |
Top |
FusionProtFeatures for PDLIM3_ZFYVE28 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PDLIM3 | ZFYVE28 |