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Fusion gene ID: 26484 |
FusionGeneSummary for PDIA3_ARF1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PDIA3_ARF1 | Fusion gene ID: 26484 | Hgene | Tgene | Gene symbol | PDIA3 | ARF1 | Gene ID | 2923 | 375 |
| Gene name | protein disulfide isomerase family A member 3 | ADP ribosylation factor 1 | |
| Synonyms | ER60|ERp57|ERp60|ERp61|GRP57|GRP58|HEL-S-269|HEL-S-93n|HsT17083|P58|PI-PLC | - | |
| Cytomap | 15q15.3 | 1q42.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein disulfide-isomerase A358 kDa glucose-regulated protein58 kDa microsomal proteinER protein 57ER protein 60disulfide isomerase ER-60endoplasmic reticulum P58endoplasmic reticulum resident protein 57endoplasmic reticulum resident protein 60e | ADP-ribosylation factor 1 | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | P30101 | P84077 | |
| Ensembl transtripts involved in fusion gene | ENST00000300289, ENST00000469684, ENST00000538521, | ENST00000272102, ENST00000540651, ENST00000478424, ENST00000541182, | |
| Fusion gene scores | * DoF score | 9 X 8 X 4=288 | 7 X 8 X 2=112 |
| # samples | 9 | 8 | |
| ** MAII score | log2(9/288*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/112*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PDIA3 [Title/Abstract] AND ARF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AV749342 | PDIA3 | chr15 | 44062741 | + | ARF1 | chr1 | 228286648 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000300289 | ENST00000272102 | PDIA3 | chr15 | 44062741 | + | ARF1 | chr1 | 228286648 | + |
| 5CDS-3UTR | ENST00000300289 | ENST00000540651 | PDIA3 | chr15 | 44062741 | + | ARF1 | chr1 | 228286648 | + |
| 5CDS-intron | ENST00000300289 | ENST00000478424 | PDIA3 | chr15 | 44062741 | + | ARF1 | chr1 | 228286648 | + |
| 5CDS-3UTR | ENST00000300289 | ENST00000541182 | PDIA3 | chr15 | 44062741 | + | ARF1 | chr1 | 228286648 | + |
| intron-3UTR | ENST00000469684 | ENST00000272102 | PDIA3 | chr15 | 44062741 | + | ARF1 | chr1 | 228286648 | + |
| intron-3UTR | ENST00000469684 | ENST00000540651 | PDIA3 | chr15 | 44062741 | + | ARF1 | chr1 | 228286648 | + |
| intron-intron | ENST00000469684 | ENST00000478424 | PDIA3 | chr15 | 44062741 | + | ARF1 | chr1 | 228286648 | + |
| intron-3UTR | ENST00000469684 | ENST00000541182 | PDIA3 | chr15 | 44062741 | + | ARF1 | chr1 | 228286648 | + |
| 5CDS-3UTR | ENST00000538521 | ENST00000272102 | PDIA3 | chr15 | 44062741 | + | ARF1 | chr1 | 228286648 | + |
| 5CDS-3UTR | ENST00000538521 | ENST00000540651 | PDIA3 | chr15 | 44062741 | + | ARF1 | chr1 | 228286648 | + |
| 5CDS-intron | ENST00000538521 | ENST00000478424 | PDIA3 | chr15 | 44062741 | + | ARF1 | chr1 | 228286648 | + |
| 5CDS-3UTR | ENST00000538521 | ENST00000541182 | PDIA3 | chr15 | 44062741 | + | ARF1 | chr1 | 228286648 | + |
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FusionProtFeatures for PDIA3_ARF1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PDIA3 | ARF1 |