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Fusion gene ID: 26467 |
FusionGeneSummary for PDGFRB_NDE1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PDGFRB_NDE1 | Fusion gene ID: 26467 | Hgene | Tgene | Gene symbol | PDGFRB | NDE1 | Gene ID | 5159 | 54820 |
| Gene name | platelet derived growth factor receptor beta | nudE neurodevelopment protein 1 | |
| Synonyms | CD140B|IBGC4|IMF1|JTK12|KOGS|PDGFR|PDGFR-1|PDGFR1|PENTT | HOM-TES-87|LIS4|MHAC|NDE|NUDE|NUDE1 | |
| Cytomap | 5q32 | 16p13.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | platelet-derived growth factor receptor betaActivated tyrosine kinase PDGFRBCD140 antigen-like family member BNDEL1-PDGFRBPDGF-R-betaPDGFR-betabeta-type platelet-derived growth factor receptorplatelet-derived growth factor receptor 1platelet-deriv | nuclear distribution protein nudE homolog 1LIS1-interacting protein NUDE1, rat homolognudE nuclear distribution E homolog 1nudE nuclear distribution gene E homolog 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P09619 | Q9NXR1 | |
| Ensembl transtripts involved in fusion gene | ENST00000261799, ENST00000523456, | ENST00000396353, ENST00000396355, ENST00000396354, ENST00000342673, ENST00000571896, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 13 X 17 X 2=442 |
| # samples | 3 | 19 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(19/442*10)=-1.21804695106048 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PDGFRB [Title/Abstract] AND NDE1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PDGFRB | GO:0007165 | signal transduction | 10821867 |
| Hgene | PDGFRB | GO:0010863 | positive regulation of phospholipase C activity | 1653029 |
| Hgene | PDGFRB | GO:0018108 | peptidyl-tyrosine phosphorylation | 1653029|2536956|2850496 |
| Hgene | PDGFRB | GO:0030335 | positive regulation of cell migration | 17470632 |
| Hgene | PDGFRB | GO:0032516 | positive regulation of phosphoprotein phosphatase activity | 7691811 |
| Hgene | PDGFRB | GO:0038091 | positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway | 17470632 |
| Hgene | PDGFRB | GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity | 1314164 |
| Hgene | PDGFRB | GO:0046777 | protein autophosphorylation | 1314164|2536956|2850496 |
| Hgene | PDGFRB | GO:0048008 | platelet-derived growth factor receptor signaling pathway | 1314164|2536956 |
| Hgene | PDGFRB | GO:0060326 | cell chemotaxis | 2554309|17991872 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DQ317513 | PDGFRB | chr5 | 149508606 | + | NDE1 | chr16 | 15784639 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000261799 | ENST00000396353 | PDGFRB | chr5 | 149508606 | + | NDE1 | chr16 | 15784639 | - |
| intron-intron | ENST00000261799 | ENST00000396355 | PDGFRB | chr5 | 149508606 | + | NDE1 | chr16 | 15784639 | - |
| intron-intron | ENST00000261799 | ENST00000396354 | PDGFRB | chr5 | 149508606 | + | NDE1 | chr16 | 15784639 | - |
| intron-intron | ENST00000261799 | ENST00000342673 | PDGFRB | chr5 | 149508606 | + | NDE1 | chr16 | 15784639 | - |
| intron-intron | ENST00000261799 | ENST00000571896 | PDGFRB | chr5 | 149508606 | + | NDE1 | chr16 | 15784639 | - |
| intron-intron | ENST00000523456 | ENST00000396353 | PDGFRB | chr5 | 149508606 | + | NDE1 | chr16 | 15784639 | - |
| intron-intron | ENST00000523456 | ENST00000396355 | PDGFRB | chr5 | 149508606 | + | NDE1 | chr16 | 15784639 | - |
| intron-intron | ENST00000523456 | ENST00000396354 | PDGFRB | chr5 | 149508606 | + | NDE1 | chr16 | 15784639 | - |
| intron-intron | ENST00000523456 | ENST00000342673 | PDGFRB | chr5 | 149508606 | + | NDE1 | chr16 | 15784639 | - |
| intron-intron | ENST00000523456 | ENST00000571896 | PDGFRB | chr5 | 149508606 | + | NDE1 | chr16 | 15784639 | - |
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FusionProtFeatures for PDGFRB_NDE1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PDGFRB | NDE1 |