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Fusion gene ID: 2646 |
FusionGeneSummary for ARID2_PTPRB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ARID2_PTPRB | Fusion gene ID: 2646 | Hgene | Tgene | Gene symbol | ARID2 | PTPRB | Gene ID | 196528 | 5787 |
| Gene name | AT-rich interaction domain 2 | protein tyrosine phosphatase, receptor type B | |
| Synonyms | BAF200|CSS6|p200 | HPTP-BETA|HPTPB|PTPB|R-PTP-BETA|VEPTP | |
| Cytomap | 12q12 | 12q15 | |
| Type of gene | protein-coding | protein-coding | |
| Description | AT-rich interactive domain-containing protein 2ARID domain-containing protein 2AT rich interactive domain 2 (ARID, RFX-like)BRG1-associated factor 200zinc finger protein with activation potentialzipzap/p200 | receptor-type tyrosine-protein phosphatase betaVE-PTPprotein tyrosine phosphatase, receptor type, beta polypeptidevascular endothelial protein tyrosine phosphatase | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q68CP9 | P23467 | |
| Ensembl transtripts involved in fusion gene | ENST00000334344, ENST00000422737, ENST00000479608, ENST00000444670, ENST00000457135, | ENST00000451516, ENST00000334414, ENST00000550358, ENST00000538708, ENST00000550857, ENST00000261266, ENST00000551525, ENST00000538174, | |
| Fusion gene scores | * DoF score | 8 X 5 X 7=280 | 4 X 4 X 4=64 |
| # samples | 8 | 4 | |
| ** MAII score | log2(8/280*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ARID2 [Title/Abstract] AND PTPRB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ARID2 | GO:0006337 | nucleosome disassembly | 8895581 |
| Hgene | ARID2 | GO:0008285 | negative regulation of cell proliferation | 26169693 |
| Hgene | ARID2 | GO:0030336 | negative regulation of cell migration | 26169693 |
| Tgene | PTPRB | GO:0016311 | dephosphorylation | 19116766|19136612 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-A6BE-01A | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000334344 | ENST00000451516 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| In-frame | ENST00000334344 | ENST00000334414 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| In-frame | ENST00000334344 | ENST00000550358 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| In-frame | ENST00000334344 | ENST00000538708 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| In-frame | ENST00000334344 | ENST00000550857 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| In-frame | ENST00000334344 | ENST00000261266 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| 5CDS-intron | ENST00000334344 | ENST00000551525 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| 5CDS-intron | ENST00000334344 | ENST00000538174 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| 5UTR-3CDS | ENST00000422737 | ENST00000451516 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| 5UTR-3CDS | ENST00000422737 | ENST00000334414 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| 5UTR-3CDS | ENST00000422737 | ENST00000550358 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| 5UTR-3CDS | ENST00000422737 | ENST00000538708 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| 5UTR-3CDS | ENST00000422737 | ENST00000550857 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| 5UTR-3CDS | ENST00000422737 | ENST00000261266 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| 5UTR-intron | ENST00000422737 | ENST00000551525 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| 5UTR-intron | ENST00000422737 | ENST00000538174 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| intron-3CDS | ENST00000479608 | ENST00000451516 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| intron-3CDS | ENST00000479608 | ENST00000334414 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| intron-3CDS | ENST00000479608 | ENST00000550358 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| intron-3CDS | ENST00000479608 | ENST00000538708 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| intron-3CDS | ENST00000479608 | ENST00000550857 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| intron-3CDS | ENST00000479608 | ENST00000261266 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| intron-intron | ENST00000479608 | ENST00000551525 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| intron-intron | ENST00000479608 | ENST00000538174 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| intron-3CDS | ENST00000444670 | ENST00000451516 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| intron-3CDS | ENST00000444670 | ENST00000334414 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| intron-3CDS | ENST00000444670 | ENST00000550358 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| intron-3CDS | ENST00000444670 | ENST00000538708 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| intron-3CDS | ENST00000444670 | ENST00000550857 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| intron-3CDS | ENST00000444670 | ENST00000261266 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| intron-intron | ENST00000444670 | ENST00000551525 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| intron-intron | ENST00000444670 | ENST00000538174 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| intron-3CDS | ENST00000457135 | ENST00000451516 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| intron-3CDS | ENST00000457135 | ENST00000334414 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| intron-3CDS | ENST00000457135 | ENST00000550358 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| intron-3CDS | ENST00000457135 | ENST00000538708 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| intron-3CDS | ENST00000457135 | ENST00000550857 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| intron-3CDS | ENST00000457135 | ENST00000261266 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| intron-intron | ENST00000457135 | ENST00000551525 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
| intron-intron | ENST00000457135 | ENST00000538174 | ARID2 | chr12 | 46125097 | + | PTPRB | chr12 | 70933802 | - |
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FusionProtFeatures for ARID2_PTPRB |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ARID2 | PTPRB |