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Fusion gene ID: 26455 |
FusionGeneSummary for PDGFD_NCCRP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PDGFD_NCCRP1 | Fusion gene ID: 26455 | Hgene | Tgene | Gene symbol | PDGFD | NCCRP1 | Gene ID | 80310 | 342897 |
| Gene name | platelet derived growth factor D | non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) | |
| Synonyms | IEGF|MSTP036|SCDGF-B|SCDGFB | FBXO50|NCCRP-1 | |
| Cytomap | 11q22.3 | 19q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | platelet-derived growth factor DPDGF-Diris-expressed growth factorspinal cord-derived growth factor B | F-box only protein 50NCC receptor protein 1 homolognonspecific cytotoxic cell receptor protein 1 homolog | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9GZP0 | Q6ZVX7 | |
| Ensembl transtripts involved in fusion gene | ENST00000393158, ENST00000302251, | ENST00000339852, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 1 X 1 X 1=1 |
| # samples | 5 | 1 | |
| ** MAII score | log2(5/18*10)=1.47393118833241 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: PDGFD [Title/Abstract] AND NCCRP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NCCRP1 | GO:0008284 | positive regulation of cell proliferation | 22087255 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AK025378 | PDGFD | chr11 | 103791147 | - | NCCRP1 | chr19 | 39692193 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000393158 | ENST00000339852 | PDGFD | chr11 | 103791147 | - | NCCRP1 | chr19 | 39692193 | + |
| intron-3UTR | ENST00000302251 | ENST00000339852 | PDGFD | chr11 | 103791147 | - | NCCRP1 | chr19 | 39692193 | + |
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FusionProtFeatures for PDGFD_NCCRP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PDGFD | NCCRP1 |