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Fusion gene ID: 26440 |
FusionGeneSummary for PDE8A_SLCO3A1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PDE8A_SLCO3A1 | Fusion gene ID: 26440 | Hgene | Tgene | Gene symbol | PDE8A | SLCO3A1 | Gene ID | 5151 | 28232 |
| Gene name | phosphodiesterase 8A | solute carrier organic anion transporter family member 3A1 | |
| Synonyms | HsT19550 | OATP-D|OATP-RP3|OATP3A1|OATPD|OATPRP3|SLC21A11 | |
| Cytomap | 15q25.3 | 15q26.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8AcAMP-specific cyclic nucleotide phosphodiesterase 8A | solute carrier organic anion transporter family member 3A1PGE1 transporterorganic anion transporter polypeptide-related protein 3organic anion-transporting polypeptide Dsodium-independent organic anion transporter Dsolute carrier family 21 (organic a | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | O60658 | Q9UIG8 | |
| Ensembl transtripts involved in fusion gene | ENST00000310298, ENST00000557957, ENST00000394553, ENST00000339708, ENST00000557819, | ENST00000318445, ENST00000424469, ENST00000555549, | |
| Fusion gene scores | * DoF score | 6 X 4 X 4=96 | 5 X 4 X 4=80 |
| # samples | 6 | 5 | |
| ** MAII score | log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PDE8A [Title/Abstract] AND SLCO3A1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-DA-A1HW-06A | PDE8A | chr15 | 85525579 | + | SLCO3A1 | chr15 | 92638111 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000310298 | ENST00000318445 | PDE8A | chr15 | 85525579 | + | SLCO3A1 | chr15 | 92638111 | + |
| Frame-shift | ENST00000310298 | ENST00000424469 | PDE8A | chr15 | 85525579 | + | SLCO3A1 | chr15 | 92638111 | + |
| 5CDS-intron | ENST00000310298 | ENST00000555549 | PDE8A | chr15 | 85525579 | + | SLCO3A1 | chr15 | 92638111 | + |
| intron-3CDS | ENST00000557957 | ENST00000318445 | PDE8A | chr15 | 85525579 | + | SLCO3A1 | chr15 | 92638111 | + |
| intron-3CDS | ENST00000557957 | ENST00000424469 | PDE8A | chr15 | 85525579 | + | SLCO3A1 | chr15 | 92638111 | + |
| intron-intron | ENST00000557957 | ENST00000555549 | PDE8A | chr15 | 85525579 | + | SLCO3A1 | chr15 | 92638111 | + |
| Frame-shift | ENST00000394553 | ENST00000318445 | PDE8A | chr15 | 85525579 | + | SLCO3A1 | chr15 | 92638111 | + |
| Frame-shift | ENST00000394553 | ENST00000424469 | PDE8A | chr15 | 85525579 | + | SLCO3A1 | chr15 | 92638111 | + |
| 5CDS-intron | ENST00000394553 | ENST00000555549 | PDE8A | chr15 | 85525579 | + | SLCO3A1 | chr15 | 92638111 | + |
| Frame-shift | ENST00000339708 | ENST00000318445 | PDE8A | chr15 | 85525579 | + | SLCO3A1 | chr15 | 92638111 | + |
| Frame-shift | ENST00000339708 | ENST00000424469 | PDE8A | chr15 | 85525579 | + | SLCO3A1 | chr15 | 92638111 | + |
| 5CDS-intron | ENST00000339708 | ENST00000555549 | PDE8A | chr15 | 85525579 | + | SLCO3A1 | chr15 | 92638111 | + |
| intron-3CDS | ENST00000557819 | ENST00000318445 | PDE8A | chr15 | 85525579 | + | SLCO3A1 | chr15 | 92638111 | + |
| intron-3CDS | ENST00000557819 | ENST00000424469 | PDE8A | chr15 | 85525579 | + | SLCO3A1 | chr15 | 92638111 | + |
| intron-intron | ENST00000557819 | ENST00000555549 | PDE8A | chr15 | 85525579 | + | SLCO3A1 | chr15 | 92638111 | + |
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FusionProtFeatures for PDE8A_SLCO3A1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PDE8A | SLCO3A1 |