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Fusion gene ID: 26424 |
FusionGeneSummary for PDE6B_INO80 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PDE6B_INO80 | Fusion gene ID: 26424 | Hgene | Tgene | Gene symbol | PDE6B | INO80 | Gene ID | 5158 | 54617 |
| Gene name | phosphodiesterase 6B | INO80 complex subunit | |
| Synonyms | CSNB3|CSNBAD2|GMP-PDEbeta|PDEB|RP40|rd1 | INO80A|INOC1|hINO80 | |
| Cytomap | 4p16.3 | 15q15.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit betaGMP-PDE betaphosphodiesterase 6B, cGMP-specific, rod, betarod cGMP-phosphodiesterase beta-subunit | DNA helicase INO80INO80 complex subunit AINO80 homologhomolog of yeast INO80putative DNA helicase INO80 complex homolog 1 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P35913 | Q9ULG1 | |
| Ensembl transtripts involved in fusion gene | ENST00000255622, ENST00000496514, ENST00000429163, | ENST00000361937, ENST00000401393, ENST00000561244, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 6 X 6 X 3=108 |
| # samples | 1 | 7 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(7/108*10)=-0.625604485218502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PDE6B [Title/Abstract] AND INO80 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BU741962 | PDE6B | chr4 | 664297 | - | INO80 | chr15 | 41291127 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-intron | ENST00000255622 | ENST00000361937 | PDE6B | chr4 | 664297 | - | INO80 | chr15 | 41291127 | + |
| 3UTR-intron | ENST00000255622 | ENST00000401393 | PDE6B | chr4 | 664297 | - | INO80 | chr15 | 41291127 | + |
| 3UTR-intron | ENST00000255622 | ENST00000561244 | PDE6B | chr4 | 664297 | - | INO80 | chr15 | 41291127 | + |
| 3UTR-intron | ENST00000496514 | ENST00000361937 | PDE6B | chr4 | 664297 | - | INO80 | chr15 | 41291127 | + |
| 3UTR-intron | ENST00000496514 | ENST00000401393 | PDE6B | chr4 | 664297 | - | INO80 | chr15 | 41291127 | + |
| 3UTR-intron | ENST00000496514 | ENST00000561244 | PDE6B | chr4 | 664297 | - | INO80 | chr15 | 41291127 | + |
| intron-intron | ENST00000429163 | ENST00000361937 | PDE6B | chr4 | 664297 | - | INO80 | chr15 | 41291127 | + |
| intron-intron | ENST00000429163 | ENST00000401393 | PDE6B | chr4 | 664297 | - | INO80 | chr15 | 41291127 | + |
| intron-intron | ENST00000429163 | ENST00000561244 | PDE6B | chr4 | 664297 | - | INO80 | chr15 | 41291127 | + |
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FusionProtFeatures for PDE6B_INO80 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PDE6B | INO80 |