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Fusion gene ID: 26418

FusionGeneSummary for PDE4D_RNF180

Fusion gene summary

Fusion gene information	Fusion gene name: PDE4D_RNF180
	Fusion gene ID: 26418
		Hgene	Tgene
	Gene symbol	PDE4D	RNF180
	Gene ID	5144	285671
	Gene name	phosphodiesterase 4D	ring finger protein 180
	Synonyms	ACRDYS2\|DPDE3\|HSPDE4D\|PDE43\|PDE4DN2\|STRK1	RINES
	Cytomap	5q11.2-q12.1	5q12.3
	Type of gene	protein-coding	protein-coding
	Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4DcAMP-specific phosphodiesterase PDE4D6phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)testicular tissue protein Li 136	E3 ubiquitin-protein ligase RNF180RING-type E3 ubiquitin transferase RNF180
	Modification date	20180519	20180523
	UniProtAcc	Q08499	Q86T96
	Ensembl transtripts involved in fusion gene	ENST00000340635, ENST00000360047, ENST00000507116, ENST00000502484, ENST00000546160, ENST00000502575, ENST00000358923, ENST00000503258, ENST00000405755, ENST00000317118, ENST00000503947,	ENST00000389100, ENST00000296615, ENST00000381081,
Fusion gene scores	* DoF score	23 X 14 X 10=3220	5 X 4 X 4=80
	# samples	34	5
	** MAII score	log2(34/3220*10)=-3.24345403686428 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PDE4D [Title/Abstract] AND RNF180 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PDE4D	GO:0006198	cAMP catabolic process	9371713\|17404263

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	KIRP	TCGA-P4-A5EB-01A	PDE4D	chr5	59064073	-	RNF180	chr5	63665442	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000340635	ENST00000389100	PDE4D	chr5	59064073	-	RNF180	chr5	63665442	+
intron-intron	ENST00000340635	ENST00000296615	PDE4D	chr5	59064073	-	RNF180	chr5	63665442	+
intron-intron	ENST00000340635	ENST00000381081	PDE4D	chr5	59064073	-	RNF180	chr5	63665442	+
intron-3CDS	ENST00000360047	ENST00000389100	PDE4D	chr5	59064073	-	RNF180	chr5	63665442	+
intron-intron	ENST00000360047	ENST00000296615	PDE4D	chr5	59064073	-	RNF180	chr5	63665442	+
intron-intron	ENST00000360047	ENST00000381081	PDE4D	chr5	59064073	-	RNF180	chr5	63665442	+
Frame-shift	ENST00000507116	ENST00000389100	PDE4D	chr5	59064073	-	RNF180	chr5	63665442	+
5CDS-intron	ENST00000507116	ENST00000296615	PDE4D	chr5	59064073	-	RNF180	chr5	63665442	+
5CDS-intron	ENST00000507116	ENST00000381081	PDE4D	chr5	59064073	-	RNF180	chr5	63665442	+
intron-3CDS	ENST00000502484	ENST00000389100	PDE4D	chr5	59064073	-	RNF180	chr5	63665442	+
intron-intron	ENST00000502484	ENST00000296615	PDE4D	chr5	59064073	-	RNF180	chr5	63665442	+
intron-intron	ENST00000502484	ENST00000381081	PDE4D	chr5	59064073	-	RNF180	chr5	63665442	+
intron-3CDS	ENST00000546160	ENST00000389100	PDE4D	chr5	59064073	-	RNF180	chr5	63665442	+
intron-intron	ENST00000546160	ENST00000296615	PDE4D	chr5	59064073	-	RNF180	chr5	63665442	+
intron-intron	ENST00000546160	ENST00000381081	PDE4D	chr5	59064073	-	RNF180	chr5	63665442	+
Frame-shift	ENST00000502575	ENST00000389100	PDE4D	chr5	59064073	-	RNF180	chr5	63665442	+
5CDS-intron	ENST00000502575	ENST00000296615	PDE4D	chr5	59064073	-	RNF180	chr5	63665442	+
5CDS-intron	ENST00000502575	ENST00000381081	PDE4D	chr5	59064073	-	RNF180	chr5	63665442	+
intron-3CDS	ENST00000358923	ENST00000389100	PDE4D	chr5	59064073	-	RNF180	chr5	63665442	+
intron-intron	ENST00000358923	ENST00000296615	PDE4D	chr5	59064073	-	RNF180	chr5	63665442	+
intron-intron	ENST00000358923	ENST00000381081	PDE4D	chr5	59064073	-	RNF180	chr5	63665442	+
intron-3CDS	ENST00000503258	ENST00000389100	PDE4D	chr5	59064073	-	RNF180	chr5	63665442	+
intron-intron	ENST00000503258	ENST00000296615	PDE4D	chr5	59064073	-	RNF180	chr5	63665442	+
intron-intron	ENST00000503258	ENST00000381081	PDE4D	chr5	59064073	-	RNF180	chr5	63665442	+
intron-3CDS	ENST00000405755	ENST00000389100	PDE4D	chr5	59064073	-	RNF180	chr5	63665442	+
intron-intron	ENST00000405755	ENST00000296615	PDE4D	chr5	59064073	-	RNF180	chr5	63665442	+
intron-intron	ENST00000405755	ENST00000381081	PDE4D	chr5	59064073	-	RNF180	chr5	63665442	+
intron-3CDS	ENST00000317118	ENST00000389100	PDE4D	chr5	59064073	-	RNF180	chr5	63665442	+
intron-intron	ENST00000317118	ENST00000296615	PDE4D	chr5	59064073	-	RNF180	chr5	63665442	+
intron-intron	ENST00000317118	ENST00000381081	PDE4D	chr5	59064073	-	RNF180	chr5	63665442	+
intron-3CDS	ENST00000503947	ENST00000389100	PDE4D	chr5	59064073	-	RNF180	chr5	63665442	+
intron-intron	ENST00000503947	ENST00000296615	PDE4D	chr5	59064073	-	RNF180	chr5	63665442	+
intron-intron	ENST00000503947	ENST00000381081	PDE4D	chr5	59064073	-	RNF180	chr5	63665442	+

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FusionProtFeatures for PDE4D_RNF180

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
PDE4D Q08499	RNF180 Q86T96

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Fusion gene ID: 26418

FusionGeneSummary for PDE4D_RNF180

FusionProtFeatures for PDE4D_RNF180