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Fusion gene ID: 26362 |
FusionGeneSummary for PDCD7_TAF15 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PDCD7_TAF15 | Fusion gene ID: 26362 | Hgene | Tgene | Gene symbol | PDCD7 | TAF15 | Gene ID | 10081 | 8148 |
| Gene name | programmed cell death 7 | TATA-box binding protein associated factor 15 | |
| Synonyms | ES18|HES18 | Npl3|RBP56|TAF2N|TAFII68 | |
| Cytomap | 15q22.31 | 17q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | programmed cell death protein 7U11/U12 snRNP 59Kapoptosis-related protein ES18 | TATA-binding protein-associated factor 2NRBP56/CSMF fusionTAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDaTATA box binding protein (TBP)-associated factor, RNA polymerase II, N, 68kD (RNA-binding protein 56)TATA box-bin | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8N8D1 | Q92804 | |
| Ensembl transtripts involved in fusion gene | ENST00000204549, | ENST00000588240, ENST00000592237, ENST00000311979, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 7 X 5 X 6=210 |
| # samples | 4 | 7 | |
| ** MAII score | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/210*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PDCD7 [Title/Abstract] AND TAF15 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-LD-A7W5-01A | PDCD7 | chr15 | 65421370 | - | TAF15 | chr17 | 34144720 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000204549 | ENST00000588240 | PDCD7 | chr15 | 65421370 | - | TAF15 | chr17 | 34144720 | + |
| 5CDS-5UTR | ENST00000204549 | ENST00000592237 | PDCD7 | chr15 | 65421370 | - | TAF15 | chr17 | 34144720 | + |
| 5CDS-5UTR | ENST00000204549 | ENST00000311979 | PDCD7 | chr15 | 65421370 | - | TAF15 | chr17 | 34144720 | + |
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FusionProtFeatures for PDCD7_TAF15 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PDCD7 | TAF15 |