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Fusion gene ID: 26346 |
FusionGeneSummary for PDCD4_CHD1L |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PDCD4_CHD1L | Fusion gene ID: 26346 | Hgene | Tgene | Gene symbol | PDCD4 | CHD1L | Gene ID | 27250 | 9557 |
| Gene name | programmed cell death 4 | chromodomain helicase DNA binding protein 1 like | |
| Synonyms | H731 | ALC1|CHDL | |
| Cytomap | 10q25.2 | 1q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | programmed cell death protein 4neoplastic transformation inhibitor proteinnuclear antigen H731programmed cell death 4 (neoplastic transformation inhibitor)protein 197/15a | chromodomain-helicase-DNA-binding protein 1-likeamplified in liver cancer 1amplified in liver cancer protein 1 | |
| Modification date | 20180527 | 20180522 | |
| UniProtAcc | Q53EL6 | Q86WJ1 | |
| Ensembl transtripts involved in fusion gene | ENST00000280154, ENST00000393104, ENST00000481353, | ENST00000431239, ENST00000369259, ENST00000369258, ENST00000467213, ENST00000361293, | |
| Fusion gene scores | * DoF score | 5 X 5 X 1=25 | 5 X 4 X 4=80 |
| # samples | 5 | 5 | |
| ** MAII score | log2(5/25*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PDCD4 [Title/Abstract] AND CHD1L [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PDCD4 | GO:0007569 | cell aging | 12054647 |
| Hgene | PDCD4 | GO:0030509 | BMP signaling pathway | 18548003 |
| Hgene | PDCD4 | GO:0045892 | negative regulation of transcription, DNA-templated | 16357133 |
| Hgene | PDCD4 | GO:1905064 | negative regulation of vascular smooth muscle cell differentiation | 18548003 |
| Tgene | CHD1L | GO:0006338 | chromatin remodeling | 19661379 |
| Tgene | CHD1L | GO:0006974 | cellular response to DNA damage stimulus | 19661379 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DA689020 | PDCD4 | chr10 | 112635830 | + | CHD1L | chr1 | 146747014 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000280154 | ENST00000431239 | PDCD4 | chr10 | 112635830 | + | CHD1L | chr1 | 146747014 | + |
| In-frame | ENST00000280154 | ENST00000369259 | PDCD4 | chr10 | 112635830 | + | CHD1L | chr1 | 146747014 | + |
| In-frame | ENST00000280154 | ENST00000369258 | PDCD4 | chr10 | 112635830 | + | CHD1L | chr1 | 146747014 | + |
| 5CDS-3UTR | ENST00000280154 | ENST00000467213 | PDCD4 | chr10 | 112635830 | + | CHD1L | chr1 | 146747014 | + |
| 5CDS-3UTR | ENST00000280154 | ENST00000361293 | PDCD4 | chr10 | 112635830 | + | CHD1L | chr1 | 146747014 | + |
| 5UTR-3CDS | ENST00000393104 | ENST00000431239 | PDCD4 | chr10 | 112635830 | + | CHD1L | chr1 | 146747014 | + |
| 5UTR-3CDS | ENST00000393104 | ENST00000369259 | PDCD4 | chr10 | 112635830 | + | CHD1L | chr1 | 146747014 | + |
| 5UTR-3CDS | ENST00000393104 | ENST00000369258 | PDCD4 | chr10 | 112635830 | + | CHD1L | chr1 | 146747014 | + |
| 5UTR-3UTR | ENST00000393104 | ENST00000467213 | PDCD4 | chr10 | 112635830 | + | CHD1L | chr1 | 146747014 | + |
| 5UTR-3UTR | ENST00000393104 | ENST00000361293 | PDCD4 | chr10 | 112635830 | + | CHD1L | chr1 | 146747014 | + |
| intron-3CDS | ENST00000481353 | ENST00000431239 | PDCD4 | chr10 | 112635830 | + | CHD1L | chr1 | 146747014 | + |
| intron-3CDS | ENST00000481353 | ENST00000369259 | PDCD4 | chr10 | 112635830 | + | CHD1L | chr1 | 146747014 | + |
| intron-3CDS | ENST00000481353 | ENST00000369258 | PDCD4 | chr10 | 112635830 | + | CHD1L | chr1 | 146747014 | + |
| intron-3UTR | ENST00000481353 | ENST00000467213 | PDCD4 | chr10 | 112635830 | + | CHD1L | chr1 | 146747014 | + |
| intron-3UTR | ENST00000481353 | ENST00000361293 | PDCD4 | chr10 | 112635830 | + | CHD1L | chr1 | 146747014 | + |
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FusionProtFeatures for PDCD4_CHD1L |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PDCD4 | CHD1L |