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Fusion gene ID: 26277 |
FusionGeneSummary for PCNP_CKB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PCNP_CKB | Fusion gene ID: 26277 | Hgene | Tgene | Gene symbol | PCNP | CKB | Gene ID | 57092 | 1152 |
| Gene name | PEST proteolytic signal containing nuclear protein | creatine kinase B | |
| Synonyms | - | B-CK|BCK|CKBB|CPK-B|HEL-211|HEL-S-29 | |
| Cytomap | 3q12.3 | 14q32.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | PEST proteolytic signal-containing nuclear proteinPEST-containing nuclear protein | creatine kinase B-typebrain creatine kinasecreatine kinase B chaincreatine kinase braincreatine kinase brain-typecreatine phosphokinase B-typeepididymis luminal protein 211epididymis secretory protein Li 29 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q8WW12 | P12277 | |
| Ensembl transtripts involved in fusion gene | ENST00000265260, ENST00000469941, ENST00000296024, ENST00000486406, | ENST00000348956, | |
| Fusion gene scores | * DoF score | 5 X 5 X 2=50 | 8 X 11 X 2=176 |
| # samples | 5 | 13 | |
| ** MAII score | log2(5/50*10)=0 | log2(13/176*10)=-0.437063805608843 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PCNP [Title/Abstract] AND CKB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PCNP | GO:0016567 | protein ubiquitination | 14741369 |
| Hgene | PCNP | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 14741369 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AI184838 | PCNP | chr3 | 101295384 | + | CKB | chr14 | 103987665 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000265260 | ENST00000348956 | PCNP | chr3 | 101295384 | + | CKB | chr14 | 103987665 | + |
| intron-3CDS | ENST00000469941 | ENST00000348956 | PCNP | chr3 | 101295384 | + | CKB | chr14 | 103987665 | + |
| intron-3CDS | ENST00000296024 | ENST00000348956 | PCNP | chr3 | 101295384 | + | CKB | chr14 | 103987665 | + |
| intron-3CDS | ENST00000486406 | ENST00000348956 | PCNP | chr3 | 101295384 | + | CKB | chr14 | 103987665 | + |
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FusionProtFeatures for PCNP_CKB |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PCNP | CKB |