|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 26249 |
FusionGeneSummary for PCM1_NAT1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PCM1_NAT1 | Fusion gene ID: 26249 | Hgene | Tgene | Gene symbol | PCM1 | NAT1 | Gene ID | 5108 | 10991 |
| Gene name | pericentriolar material 1 | solute carrier family 38 member 3 | |
| Synonyms | PTC4|RET/PCM-1 | G17|NAT1|SN1|SNAT3 | |
| Cytomap | 8p22 | 3p21.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | pericentriolar material 1 proteinPCM-1hPCM-1pericentriolar material 1, PCM1 | sodium-coupled neutral amino acid transporter 3N-system amino acid transporter 1Na(+)-coupled neutral amino acid transporter 3system N amino acid transporter 1system N1 Na+ and H+-coupled glutamine transporter | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q15154 | P18440 | |
| Ensembl transtripts involved in fusion gene | ENST00000325083, ENST00000519253, ENST00000524226, ENST00000518537, ENST00000518936, ENST00000327578, | ENST00000517441, ENST00000535084, ENST00000307719, ENST00000539092, ENST00000541942, ENST00000545197, ENST00000518029, ENST00000517492, ENST00000520546, | |
| Fusion gene scores | * DoF score | 8 X 7 X 5=280 | 2 X 2 X 2=8 |
| # samples | 8 | 2 | |
| ** MAII score | log2(8/280*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: PCM1 [Title/Abstract] AND NAT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NAT1 | GO:0006867 | asparagine transport | 10823827 |
| Tgene | NAT1 | GO:0006868 | glutamine transport | 10823827 |
| Tgene | NAT1 | GO:0015808 | L-alanine transport | 10823827 |
| Tgene | NAT1 | GO:0015817 | histidine transport | 10823827 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A1-A0SD-01A | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000325083 | ENST00000517441 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| 5CDS-3UTR | ENST00000325083 | ENST00000535084 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| 5CDS-intron | ENST00000325083 | ENST00000307719 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| 5CDS-intron | ENST00000325083 | ENST00000539092 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| 5CDS-intron | ENST00000325083 | ENST00000541942 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| 5CDS-intron | ENST00000325083 | ENST00000545197 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| 5CDS-intron | ENST00000325083 | ENST00000518029 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| 5CDS-intron | ENST00000325083 | ENST00000517492 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| 5CDS-intron | ENST00000325083 | ENST00000520546 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| 5CDS-3UTR | ENST00000519253 | ENST00000517441 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| 5CDS-3UTR | ENST00000519253 | ENST00000535084 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| 5CDS-intron | ENST00000519253 | ENST00000307719 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| 5CDS-intron | ENST00000519253 | ENST00000539092 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| 5CDS-intron | ENST00000519253 | ENST00000541942 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| 5CDS-intron | ENST00000519253 | ENST00000545197 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| 5CDS-intron | ENST00000519253 | ENST00000518029 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| 5CDS-intron | ENST00000519253 | ENST00000517492 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| 5CDS-intron | ENST00000519253 | ENST00000520546 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| 5CDS-3UTR | ENST00000524226 | ENST00000517441 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| 5CDS-3UTR | ENST00000524226 | ENST00000535084 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| 5CDS-intron | ENST00000524226 | ENST00000307719 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| 5CDS-intron | ENST00000524226 | ENST00000539092 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| 5CDS-intron | ENST00000524226 | ENST00000541942 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| 5CDS-intron | ENST00000524226 | ENST00000545197 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| 5CDS-intron | ENST00000524226 | ENST00000518029 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| 5CDS-intron | ENST00000524226 | ENST00000517492 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| 5CDS-intron | ENST00000524226 | ENST00000520546 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| intron-3UTR | ENST00000518537 | ENST00000517441 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| intron-3UTR | ENST00000518537 | ENST00000535084 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| intron-intron | ENST00000518537 | ENST00000307719 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| intron-intron | ENST00000518537 | ENST00000539092 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| intron-intron | ENST00000518537 | ENST00000541942 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| intron-intron | ENST00000518537 | ENST00000545197 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| intron-intron | ENST00000518537 | ENST00000518029 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| intron-intron | ENST00000518537 | ENST00000517492 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| intron-intron | ENST00000518537 | ENST00000520546 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| intron-3UTR | ENST00000518936 | ENST00000517441 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| intron-3UTR | ENST00000518936 | ENST00000535084 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| intron-intron | ENST00000518936 | ENST00000307719 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| intron-intron | ENST00000518936 | ENST00000539092 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| intron-intron | ENST00000518936 | ENST00000541942 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| intron-intron | ENST00000518936 | ENST00000545197 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| intron-intron | ENST00000518936 | ENST00000518029 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| intron-intron | ENST00000518936 | ENST00000517492 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| intron-intron | ENST00000518936 | ENST00000520546 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| 5CDS-3UTR | ENST00000327578 | ENST00000517441 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| 5CDS-3UTR | ENST00000327578 | ENST00000535084 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| 5CDS-intron | ENST00000327578 | ENST00000307719 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| 5CDS-intron | ENST00000327578 | ENST00000539092 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| 5CDS-intron | ENST00000327578 | ENST00000541942 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| 5CDS-intron | ENST00000327578 | ENST00000545197 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| 5CDS-intron | ENST00000327578 | ENST00000518029 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| 5CDS-intron | ENST00000327578 | ENST00000517492 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
| 5CDS-intron | ENST00000327578 | ENST00000520546 | PCM1 | chr8 | 17843596 | + | NAT1 | chr8 | 18028188 | + |
Top |
FusionProtFeatures for PCM1_NAT1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PCM1 | NAT1 |