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Fusion gene ID: 26234

FusionGeneSummary for PCID2_SNRPA

Fusion gene summary

Fusion gene information	Fusion gene name: PCID2_SNRPA
	Fusion gene ID: 26234
		Hgene	Tgene
	Gene symbol	PCID2	SNRPA
	Gene ID	55795	6626
	Gene name	PCI domain containing 2	small nuclear ribonucleoprotein polypeptide A
	Synonyms	F10	Mud1\|U1-A\|U1A
	Cytomap	13q34	19q13.2
	Type of gene	protein-coding	protein-coding
	Description	PCI domain-containing protein 2CSN12-like protein	U1 small nuclear ribonucleoprotein AU1 small nuclear RNP-specific AU1 snRNP AU1 snRNP-specific protein A
	Modification date	20180523	20180523
	UniProtAcc	Q5JVF3	P09012
	Ensembl transtripts involved in fusion gene	ENST00000337344, ENST00000375477, ENST00000375479, ENST00000493650, ENST00000375459, ENST00000246505, ENST00000375457,	ENST00000243563, ENST00000599570,
Fusion gene scores	* DoF score	5 X 3 X 4=60	2 X 2 X 2=8
	# samples	4	2
	** MAII score	log2(4/60*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: PCID2 [Title/Abstract] AND SNRPA [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	LGG	TCGA-E1-A7Z2-01A	PCID2	chr13	113862913	-	SNRPA	chr19	41265336	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000337344	ENST00000243563	PCID2	chr13	113862913	-	SNRPA	chr19	41265336	+
5CDS-3UTR	ENST00000337344	ENST00000599570	PCID2	chr13	113862913	-	SNRPA	chr19	41265336	+
In-frame	ENST00000375477	ENST00000243563	PCID2	chr13	113862913	-	SNRPA	chr19	41265336	+
5CDS-3UTR	ENST00000375477	ENST00000599570	PCID2	chr13	113862913	-	SNRPA	chr19	41265336	+
In-frame	ENST00000375479	ENST00000243563	PCID2	chr13	113862913	-	SNRPA	chr19	41265336	+
5CDS-3UTR	ENST00000375479	ENST00000599570	PCID2	chr13	113862913	-	SNRPA	chr19	41265336	+
intron-3CDS	ENST00000493650	ENST00000243563	PCID2	chr13	113862913	-	SNRPA	chr19	41265336	+
intron-3UTR	ENST00000493650	ENST00000599570	PCID2	chr13	113862913	-	SNRPA	chr19	41265336	+
intron-3CDS	ENST00000375459	ENST00000243563	PCID2	chr13	113862913	-	SNRPA	chr19	41265336	+
intron-3UTR	ENST00000375459	ENST00000599570	PCID2	chr13	113862913	-	SNRPA	chr19	41265336	+
In-frame	ENST00000246505	ENST00000243563	PCID2	chr13	113862913	-	SNRPA	chr19	41265336	+
5CDS-3UTR	ENST00000246505	ENST00000599570	PCID2	chr13	113862913	-	SNRPA	chr19	41265336	+
intron-3CDS	ENST00000375457	ENST00000243563	PCID2	chr13	113862913	-	SNRPA	chr19	41265336	+
intron-3UTR	ENST00000375457	ENST00000599570	PCID2	chr13	113862913	-	SNRPA	chr19	41265336	+

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FusionProtFeatures for PCID2_SNRPA

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
PCID2 Q5JVF3	SNRPA P09012

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Fusion gene ID: 26234

FusionGeneSummary for PCID2_SNRPA

FusionProtFeatures for PCID2_SNRPA