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Fusion gene ID: 26179 |
FusionGeneSummary for PCCA_SERPINE1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PCCA_SERPINE1 | Fusion gene ID: 26179 | Hgene | Tgene | Gene symbol | PCCA | SERPINE1 | Gene ID | 5095 | 5054 |
| Gene name | propionyl-CoA carboxylase subunit alpha | serpin family E member 1 | |
| Synonyms | - | PAI|PAI-1|PAI1|PLANH1 | |
| Cytomap | 13q32.3 | 7q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | propionyl-CoA carboxylase alpha chain, mitochondrialPCCase alpha subunitpccA complementation grouppropanoyl-CoA:carbon dioxide ligase alpha subunitpropionyl CoA carboxylase, alpha polypeptidepropionyl Coenzyme A carboxylase, alpha polypeptidepropion | plasminogen activator inhibitor 1endothelial plasminogen activator inhibitorserine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1serpin E1serpin peptidase inhibitor, clade E (nexin, plasminogen ac | |
| Modification date | 20180522 | 20180527 | |
| UniProtAcc | P05165 | P05121 | |
| Ensembl transtripts involved in fusion gene | ENST00000376279, ENST00000376286, ENST00000376285, ENST00000485946, | ENST00000223095, ENST00000445463, | |
| Fusion gene scores | * DoF score | 11 X 9 X 8=792 | 6 X 6 X 1=36 |
| # samples | 15 | 6 | |
| ** MAII score | log2(15/792*10)=-2.40053792958373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/36*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PCCA [Title/Abstract] AND SERPINE1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SERPINE1 | GO:0010469 | regulation of signaling receptor activity | 8837777 |
| Tgene | SERPINE1 | GO:0010757 | negative regulation of plasminogen activation | 8508955 |
| Tgene | SERPINE1 | GO:0010951 | negative regulation of endopeptidase activity | 1695900 |
| Tgene | SERPINE1 | GO:0014912 | negative regulation of smooth muscle cell migration | 8837777 |
| Tgene | SERPINE1 | GO:0030336 | negative regulation of cell migration | 10902815 |
| Tgene | SERPINE1 | GO:0033629 | negative regulation of cell adhesion mediated by integrin | 8837777 |
| Tgene | SERPINE1 | GO:0048260 | positive regulation of receptor-mediated endocytosis | 8626514 |
| Tgene | SERPINE1 | GO:0051918 | negative regulation of fibrinolysis | 2503541 |
| Tgene | SERPINE1 | GO:0097187 | dentinogenesis | 27046084 |
| Tgene | SERPINE1 | GO:1901331 | positive regulation of odontoblast differentiation | 27046084 |
| Tgene | SERPINE1 | GO:2000098 | negative regulation of smooth muscle cell-matrix adhesion | 8837777 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BG980943 | PCCA | chr13 | 101119337 | - | SERPINE1 | chr7 | 100780774 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000376279 | ENST00000223095 | PCCA | chr13 | 101119337 | - | SERPINE1 | chr7 | 100780774 | - |
| intron-3UTR | ENST00000376279 | ENST00000445463 | PCCA | chr13 | 101119337 | - | SERPINE1 | chr7 | 100780774 | - |
| intron-3UTR | ENST00000376286 | ENST00000223095 | PCCA | chr13 | 101119337 | - | SERPINE1 | chr7 | 100780774 | - |
| intron-3UTR | ENST00000376286 | ENST00000445463 | PCCA | chr13 | 101119337 | - | SERPINE1 | chr7 | 100780774 | - |
| intron-3UTR | ENST00000376285 | ENST00000223095 | PCCA | chr13 | 101119337 | - | SERPINE1 | chr7 | 100780774 | - |
| intron-3UTR | ENST00000376285 | ENST00000445463 | PCCA | chr13 | 101119337 | - | SERPINE1 | chr7 | 100780774 | - |
| intron-3UTR | ENST00000485946 | ENST00000223095 | PCCA | chr13 | 101119337 | - | SERPINE1 | chr7 | 100780774 | - |
| intron-3UTR | ENST00000485946 | ENST00000445463 | PCCA | chr13 | 101119337 | - | SERPINE1 | chr7 | 100780774 | - |
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FusionProtFeatures for PCCA_SERPINE1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PCCA | SERPINE1 |