|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 26060 |
FusionGeneSummary for PATL1_TECTA |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PATL1_TECTA | Fusion gene ID: 26060 | Hgene | Tgene | Gene symbol | PATL1 | TECTA | Gene ID | 219988 | 7007 |
| Gene name | PAT1 homolog 1, processing body mRNA decay factor | tectorin alpha | |
| Synonyms | Pat1b|hPat1b | DFNA12|DFNA8|DFNB21 | |
| Cytomap | 11q12.1 | 11q23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein PAT1 homolog 1PAT1-like protein 1protein PAT1 homolog bprotein associated with topoisomerase II homolog 1 | alpha-tectorin | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q86TB9 | O75443 | |
| Ensembl transtripts involved in fusion gene | ENST00000300146, | ENST00000392793, ENST00000264037, ENST00000478058, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 2 X 5=40 |
| # samples | 1 | 5 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PATL1 [Title/Abstract] AND TECTA [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PATL1 | GO:0000290 | deadenylation-dependent decapping of nuclear-transcribed mRNA | 20584987|20852261 |
| Hgene | PATL1 | GO:0033962 | cytoplasmic mRNA processing body assembly | 20584987 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | GBM | TCGA-26-5132-01A | PATL1 | chr11 | 59434326 | - | TECTA | chr11 | 121058541 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000300146 | ENST00000392793 | PATL1 | chr11 | 59434326 | - | TECTA | chr11 | 121058541 | + |
| Frame-shift | ENST00000300146 | ENST00000264037 | PATL1 | chr11 | 59434326 | - | TECTA | chr11 | 121058541 | + |
| 5CDS-intron | ENST00000300146 | ENST00000478058 | PATL1 | chr11 | 59434326 | - | TECTA | chr11 | 121058541 | + |
Top |
FusionProtFeatures for PATL1_TECTA |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PATL1 | TECTA |