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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2604

FusionGeneSummary for ARID1A_BEND5

check button Fusion gene summary
Fusion gene informationFusion gene name: ARID1A_BEND5
Fusion gene ID: 2604
HgeneTgene
Gene symbol

ARID1A

BEND5

Gene ID

8289

79656

Gene nameAT-rich interaction domain 1ABEN domain containing 5
SynonymsB120|BAF250|BAF250a|BM029|C1orf4|CSS2|ELD|MRD14|OSA1|P270|SMARCF1|hELD|hOSA1C1orf165
Cytomap

1p36.11

1p33

Type of geneprotein-codingprotein-coding
DescriptionAT-rich interactive domain-containing protein 1AARID domain-containing protein 1AAT rich interactive domain 1A (SWI-like)BRG1-associated factor 250aOSA1 nuclear proteinSWI-like proteinSWI/SNF complex protein p270SWI/SNF-related, matrix-associated, BEN domain-containing protein 5
Modification date2018051920180519
UniProtAcc

O14497

Q7L4P6

Ensembl transtripts involved in fusion geneENST00000324856, ENST00000457599, 
ENST00000374152, ENST00000540690, 
ENST00000371833, ENST00000476096, 
Fusion gene scores* DoF score21 X 13 X 13=35493 X 2 X 3=18
# samples 314
** MAII scorelog2(31/3549*10)=-3.51707245378671
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ARID1A [Title/Abstract] AND BEND5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARID1A

GO:0006337

nucleosome disassembly

8895581

HgeneARID1A

GO:0006338

chromatin remodeling

11726552

HgeneARID1A

GO:0030520

intracellular estrogen receptor signaling pathway

12200431

HgeneARID1A

GO:0030521

androgen receptor signaling pathway

12200431

HgeneARID1A

GO:0042921

glucocorticoid receptor signaling pathway

12200431

HgeneARID1A

GO:0045893

positive regulation of transcription, DNA-templated

12200431

TgeneBEND5

GO:0045892

negative regulation of transcription, DNA-templated

23468431


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVGBMTCGA-28-2514-01AARID1Achr1

27024031

+BEND5chr1

49202124

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000324856ENST00000371833ARID1Achr1

27024031

+BEND5chr1

49202124

-
5CDS-intronENST00000324856ENST00000476096ARID1Achr1

27024031

+BEND5chr1

49202124

-
In-frameENST00000457599ENST00000371833ARID1Achr1

27024031

+BEND5chr1

49202124

-
5CDS-intronENST00000457599ENST00000476096ARID1Achr1

27024031

+BEND5chr1

49202124

-
intron-3CDSENST00000374152ENST00000371833ARID1Achr1

27024031

+BEND5chr1

49202124

-
intron-intronENST00000374152ENST00000476096ARID1Achr1

27024031

+BEND5chr1

49202124

-
intron-3CDSENST00000540690ENST00000371833ARID1Achr1

27024031

+BEND5chr1

49202124

-
intron-intronENST00000540690ENST00000476096ARID1Achr1

27024031

+BEND5chr1

49202124

-

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FusionProtFeatures for ARID1A_BEND5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARID1A

O14497

BEND5

Q7L4P6

Acts as a transcriptional repressor (PubMed:23468431).{ECO:0000269|PubMed:23468431}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARID1Achr1:27024031chr1:49202124ENST00000324856+120295_2993792286MotifNote=LXXLL
HgeneARID1Achr1:27024031chr1:49202124ENST00000457599+120295_2993792069MotifNote=LXXLL
TgeneBEND5chr1:27024031chr1:49202124ENST00000371833-36302_408298422DomainBEN

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARID1Achr1:27024031chr1:49202124ENST00000324856+1201327_14043792286Compositional biasNote=Gln-rich
HgeneARID1Achr1:27024031chr1:49202124ENST00000324856+120479_4823792286Compositional biasNote=Poly-Gln
HgeneARID1Achr1:27024031chr1:49202124ENST00000324856+120561_5673792286Compositional biasNote=Poly-Gln
HgeneARID1Achr1:27024031chr1:49202124ENST00000324856+120998_10013792286Compositional biasNote=Poly-Ser
HgeneARID1Achr1:27024031chr1:49202124ENST00000374152+1191327_1404-951903Compositional biasNote=Gln-rich
HgeneARID1Achr1:27024031chr1:49202124ENST00000374152+119479_482-951903Compositional biasNote=Poly-Gln
HgeneARID1Achr1:27024031chr1:49202124ENST00000374152+119561_567-951903Compositional biasNote=Poly-Gln
HgeneARID1Achr1:27024031chr1:49202124ENST00000374152+119998_1001-951903Compositional biasNote=Poly-Ser
HgeneARID1Achr1:27024031chr1:49202124ENST00000457599+1201327_14043792069Compositional biasNote=Gln-rich
HgeneARID1Achr1:27024031chr1:49202124ENST00000457599+120479_4823792069Compositional biasNote=Poly-Gln
HgeneARID1Achr1:27024031chr1:49202124ENST00000457599+120561_5673792069Compositional biasNote=Poly-Gln
HgeneARID1Achr1:27024031chr1:49202124ENST00000457599+120998_10013792069Compositional biasNote=Poly-Ser
HgeneARID1Achr1:27024031chr1:49202124ENST00000324856+1201017_11083792286DomainARID
HgeneARID1Achr1:27024031chr1:49202124ENST00000374152+1191017_1108-951903DomainARID
HgeneARID1Achr1:27024031chr1:49202124ENST00000457599+1201017_11083792069DomainARID
HgeneARID1Achr1:27024031chr1:49202124ENST00000324856+1201368_13873792286MotifNuclear localization signal
HgeneARID1Achr1:27024031chr1:49202124ENST00000324856+1201709_17133792286MotifNote=LXXLL
HgeneARID1Achr1:27024031chr1:49202124ENST00000324856+1201967_19713792286MotifNote=LXXLL
HgeneARID1Achr1:27024031chr1:49202124ENST00000324856+1202085_20893792286MotifNote=LXXLL
HgeneARID1Achr1:27024031chr1:49202124ENST00000374152+1191368_1387-951903MotifNuclear localization signal
HgeneARID1Achr1:27024031chr1:49202124ENST00000374152+1191709_1713-951903MotifNote=LXXLL
HgeneARID1Achr1:27024031chr1:49202124ENST00000374152+1191967_1971-951903MotifNote=LXXLL
HgeneARID1Achr1:27024031chr1:49202124ENST00000374152+1192085_2089-951903MotifNote=LXXLL
HgeneARID1Achr1:27024031chr1:49202124ENST00000374152+119295_299-951903MotifNote=LXXLL
HgeneARID1Achr1:27024031chr1:49202124ENST00000457599+1201368_13873792069MotifNuclear localization signal
HgeneARID1Achr1:27024031chr1:49202124ENST00000457599+1201709_17133792069MotifNote=LXXLL
HgeneARID1Achr1:27024031chr1:49202124ENST00000457599+1201967_19713792069MotifNote=LXXLL
HgeneARID1Achr1:27024031chr1:49202124ENST00000457599+1202085_20893792069MotifNote=LXXLL
TgeneBEND5chr1:27024031chr1:49202124ENST00000371833-36180_243298422Coiled coilOntology_term=ECO:0000255


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FusionGeneSequence for ARID1A_BEND5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ARID1A_ENST00000324856_chr1_27024031_+_BEND5_ENST00000371833_chr1_49202124_-_503aa
MAAQVAPAAASSLGNPPPPPPSELKKAEQQQREEAGGEAAAAAAAERGEMKAAAGQESEGPAVGPPQPLGKELQDGAESNGGGGGGGAGS
GGGPGAEPDLKNSNGNAGPRPALNNNLTEPPGGGGGGSSDGVGAPPHSAAAALPPPAYGFGQPYGRSPSAVAAAAAAVFHQQHGGQQSPG
LAALQSGGGGGLEPYAGPQQNSHDHGFPNHQYNSYYPNRSAYPPPAPAYALSSPRGGTPGSGAAAAAGSKPPPSSSASASSSSSSFAQQR
FGAMGGGGPSAAGGGTPQPTATPTLNQLLTSPSSARGYQGYPGGDYSGGPQDGGAGKGPADMASQCWGAAAAAAAAAAASGGAQQRSHHA
PMSPGSSGGGGQPLARTPQVHLGSGIWVDEEKWHQLQVTQGDSKYTKNLAVMIWGTDVLKNRSVTGVATKKKKDAVPKPPLSPHKLSIVR

>In-frame_ARID1A_ENST00000457599_chr1_27024031_+_BEND5_ENST00000371833_chr1_49202124_-_503aa
MAAQVAPAAASSLGNPPPPPPSELKKAEQQQREEAGGEAAAAAAAERGEMKAAAGQESEGPAVGPPQPLGKELQDGAESNGGGGGGGAGS
GGGPGAEPDLKNSNGNAGPRPALNNNLTEPPGGGGGGSSDGVGAPPHSAAAALPPPAYGFGQPYGRSPSAVAAAAAAVFHQQHGGQQSPG
LAALQSGGGGGLEPYAGPQQNSHDHGFPNHQYNSYYPNRSAYPPPAPAYALSSPRGGTPGSGAAAAAGSKPPPSSSASASSSSSSFAQQR
FGAMGGGGPSAAGGGTPQPTATPTLNQLLTSPSSARGYQGYPGGDYSGGPQDGGAGKGPADMASQCWGAAAAAAAAAAASGGAQQRSHHA
PMSPGSSGGGGQPLARTPQVHLGSGIWVDEEKWHQLQVTQGDSKYTKNLAVMIWGTDVLKNRSVTGVATKKKKDAVPKPPLSPHKLSIVR


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ARID1A_ENST00000324856_chr1_27024031_+_BEND5_ENST00000371833_chr1_49202124_-_1509nt
ATGGCCGCGCAGGTCGCCCCCGCCGCCGCCAGCAGCCTGGGCAACCCGCCGCCGCCGCCGCCCTCGGAGCTGAAGAAAGCCGAGCAGCAG
CAGCGGGAGGAGGCGGGGGGCGAGGCGGCGGCGGCGGCAGCGGCCGAGCGCGGGGAAATGAAGGCAGCCGCCGGGCAGGAAAGCGAGGGC
CCCGCCGTGGGGCCGCCGCAGCCGCTGGGAAAGGAGCTGCAGGACGGGGCCGAGAGCAATGGGGGTGGCGGCGGCGGCGGAGCCGGCAGC
GGCGGCGGGCCCGGCGCGGAGCCGGACCTGAAGAACTCGAACGGGAACGCGGGCCCTAGGCCCGCCCTGAACAATAACCTCACGGAGCCG
CCCGGCGGCGGCGGTGGCGGCAGCAGCGATGGGGTGGGGGCGCCTCCTCACTCAGCCGCGGCCGCCTTGCCGCCCCCAGCCTACGGCTTC
GGGCAACCCTACGGCCGGAGCCCGTCTGCCGTCGCCGCCGCCGCGGCCGCCGTCTTCCACCAACAACATGGCGGACAACAAAGCCCTGGC
CTGGCAGCGCTGCAGAGCGGCGGCGGCGGGGGCCTGGAGCCCTACGCGGGGCCCCAGCAGAACTCTCACGACCACGGCTTCCCCAACCAC
CAGTACAACTCCTACTACCCCAACCGCAGCGCCTACCCCCCGCCCGCCCCGGCCTACGCGCTGAGCTCCCCGAGAGGTGGCACTCCGGGC
TCCGGCGCGGCGGCGGCTGCCGGCTCCAAGCCGCCTCCCTCCTCCAGCGCCTCCGCCTCCTCGTCGTCTTCGTCCTTCGCTCAGCAGCGC
TTCGGGGCCATGGGGGGAGGCGGCCCCTCCGCGGCCGGCGGGGGAACTCCCCAGCCCACCGCCACCCCCACCCTCAACCAACTGCTCACG
TCGCCCAGCTCGGCCCGGGGCTACCAGGGCTACCCCGGGGGCGACTACAGTGGCGGGCCCCAGGACGGGGGCGCCGGCAAGGGCCCGGCG
GACATGGCCTCGCAGTGTTGGGGGGCTGCGGCGGCGGCAGCTGCGGCGGCGGCCGCCTCGGGAGGGGCCCAACAAAGGAGCCACCACGCG
CCCATGAGCCCCGGGAGCAGCGGCGGCGGGGGGCAGCCGCTCGCCCGGACCCCTCAGGTCCATCTGGGAAGCGGGATTTGGGTTGATGAG
GAGAAATGGCACCAGCTACAAGTAACCCAAGGAGATTCCAAGTACACGAAGAACTTGGCAGTTATGATTTGGGGAACAGATGTTCTGAAA
AACAGAAGCGTCACAGGCGTCGCCACAAAAAAAAAGAAAGATGCAGTCCCTAAACCACCCCTCTCGCCTCACAAACTAAGCATCGTCAGA
GAGTGTTTGTATGACAGAATAGCACAAGAAACTGTGGATGAAACTGAAATTGCACAGAGACTCTCCAAAGTCAACAAGTACATCTGTGAA

>In-frame_ARID1A_ENST00000457599_chr1_27024031_+_BEND5_ENST00000371833_chr1_49202124_-_1509nt
ATGGCCGCGCAGGTCGCCCCCGCCGCCGCCAGCAGCCTGGGCAACCCGCCGCCGCCGCCGCCCTCGGAGCTGAAGAAAGCCGAGCAGCAG
CAGCGGGAGGAGGCGGGGGGCGAGGCGGCGGCGGCGGCAGCGGCCGAGCGCGGGGAAATGAAGGCAGCCGCCGGGCAGGAAAGCGAGGGC
CCCGCCGTGGGGCCGCCGCAGCCGCTGGGAAAGGAGCTGCAGGACGGGGCCGAGAGCAATGGGGGTGGCGGCGGCGGCGGAGCCGGCAGC
GGCGGCGGGCCCGGCGCGGAGCCGGACCTGAAGAACTCGAACGGGAACGCGGGCCCTAGGCCCGCCCTGAACAATAACCTCACGGAGCCG
CCCGGCGGCGGCGGTGGCGGCAGCAGCGATGGGGTGGGGGCGCCTCCTCACTCAGCCGCGGCCGCCTTGCCGCCCCCAGCCTACGGCTTC
GGGCAACCCTACGGCCGGAGCCCGTCTGCCGTCGCCGCCGCCGCGGCCGCCGTCTTCCACCAACAACATGGCGGACAACAAAGCCCTGGC
CTGGCAGCGCTGCAGAGCGGCGGCGGCGGGGGCCTGGAGCCCTACGCGGGGCCCCAGCAGAACTCTCACGACCACGGCTTCCCCAACCAC
CAGTACAACTCCTACTACCCCAACCGCAGCGCCTACCCCCCGCCCGCCCCGGCCTACGCGCTGAGCTCCCCGAGAGGTGGCACTCCGGGC
TCCGGCGCGGCGGCGGCTGCCGGCTCCAAGCCGCCTCCCTCCTCCAGCGCCTCCGCCTCCTCGTCGTCTTCGTCCTTCGCTCAGCAGCGC
TTCGGGGCCATGGGGGGAGGCGGCCCCTCCGCGGCCGGCGGGGGAACTCCCCAGCCCACCGCCACCCCCACCCTCAACCAACTGCTCACG
TCGCCCAGCTCGGCCCGGGGCTACCAGGGCTACCCCGGGGGCGACTACAGTGGCGGGCCCCAGGACGGGGGCGCCGGCAAGGGCCCGGCG
GACATGGCCTCGCAGTGTTGGGGGGCTGCGGCGGCGGCAGCTGCGGCGGCGGCCGCCTCGGGAGGGGCCCAACAAAGGAGCCACCACGCG
CCCATGAGCCCCGGGAGCAGCGGCGGCGGGGGGCAGCCGCTCGCCCGGACCCCTCAGGTCCATCTGGGAAGCGGGATTTGGGTTGATGAG
GAGAAATGGCACCAGCTACAAGTAACCCAAGGAGATTCCAAGTACACGAAGAACTTGGCAGTTATGATTTGGGGAACAGATGTTCTGAAA
AACAGAAGCGTCACAGGCGTCGCCACAAAAAAAAAGAAAGATGCAGTCCCTAAACCACCCCTCTCGCCTCACAAACTAAGCATCGTCAGA
GAGTGTTTGTATGACAGAATAGCACAAGAAACTGTGGATGAAACTGAAATTGCACAGAGACTCTCCAAAGTCAACAAGTACATCTGTGAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_ARID1A_ENST00000324856_chr1_27024031_+_BEND5_ENST00000371833_chr1_49202124_-_2243nt
GAAAGCGGAGAGTCACAGCGGGGCCAGGCCCTGGGGAGCGGAGCCTCCACCGCCCCCCTCATTCCCAGGCAAGGGCTTGGGGGGAATGAG
CCGGGAGAGCCGGGTCCCGAGCCTACAGAGCCGGGAGCAGCTGAGCCGCCGGCGCCTCGGCCGCCGCCGCCGCCTCCTCCTCCTCCGCCG
CCGCCAGCCCGGAGCCTGAGCCGGCGGGGCGGGGGGGAGAGGAGCGAGCGCAGCGCAGCAGCGGAGCCCCGCGAGGCCCGCCCGGGCGGG
TGGGGAGGGCAGCCCGGGGGACTGGGCCCCGGGGCGGGGTGGGAGGGGGGGAGAAGACGAAGACAGGGCCGGGTCTCTCCGCGGACGAGA
CAGCGGGGATCATGGCCGCGCAGGTCGCCCCCGCCGCCGCCAGCAGCCTGGGCAACCCGCCGCCGCCGCCGCCCTCGGAGCTGAAGAAAG
CCGAGCAGCAGCAGCGGGAGGAGGCGGGGGGCGAGGCGGCGGCGGCGGCAGCGGCCGAGCGCGGGGAAATGAAGGCAGCCGCCGGGCAGG
AAAGCGAGGGCCCCGCCGTGGGGCCGCCGCAGCCGCTGGGAAAGGAGCTGCAGGACGGGGCCGAGAGCAATGGGGGTGGCGGCGGCGGCG
GAGCCGGCAGCGGCGGCGGGCCCGGCGCGGAGCCGGACCTGAAGAACTCGAACGGGAACGCGGGCCCTAGGCCCGCCCTGAACAATAACC
TCACGGAGCCGCCCGGCGGCGGCGGTGGCGGCAGCAGCGATGGGGTGGGGGCGCCTCCTCACTCAGCCGCGGCCGCCTTGCCGCCCCCAG
CCTACGGCTTCGGGCAACCCTACGGCCGGAGCCCGTCTGCCGTCGCCGCCGCCGCGGCCGCCGTCTTCCACCAACAACATGGCGGACAAC
AAAGCCCTGGCCTGGCAGCGCTGCAGAGCGGCGGCGGCGGGGGCCTGGAGCCCTACGCGGGGCCCCAGCAGAACTCTCACGACCACGGCT
TCCCCAACCACCAGTACAACTCCTACTACCCCAACCGCAGCGCCTACCCCCCGCCCGCCCCGGCCTACGCGCTGAGCTCCCCGAGAGGTG
GCACTCCGGGCTCCGGCGCGGCGGCGGCTGCCGGCTCCAAGCCGCCTCCCTCCTCCAGCGCCTCCGCCTCCTCGTCGTCTTCGTCCTTCG
CTCAGCAGCGCTTCGGGGCCATGGGGGGAGGCGGCCCCTCCGCGGCCGGCGGGGGAACTCCCCAGCCCACCGCCACCCCCACCCTCAACC
AACTGCTCACGTCGCCCAGCTCGGCCCGGGGCTACCAGGGCTACCCCGGGGGCGACTACAGTGGCGGGCCCCAGGACGGGGGCGCCGGCA
AGGGCCCGGCGGACATGGCCTCGCAGTGTTGGGGGGCTGCGGCGGCGGCAGCTGCGGCGGCGGCCGCCTCGGGAGGGGCCCAACAAAGGA
GCCACCACGCGCCCATGAGCCCCGGGAGCAGCGGCGGCGGGGGGCAGCCGCTCGCCCGGACCCCTCAGGTCCATCTGGGAAGCGGGATTT
GGGTTGATGAGGAGAAATGGCACCAGCTACAAGTAACCCAAGGAGATTCCAAGTACACGAAGAACTTGGCAGTTATGATTTGGGGAACAG
ATGTTCTGAAAAACAGAAGCGTCACAGGCGTCGCCACAAAAAAAAAGAAAGATGCAGTCCCTAAACCACCCCTCTCGCCTCACAAACTAA
GCATCGTCAGAGAGTGTTTGTATGACAGAATAGCACAAGAAACTGTGGATGAAACTGAAATTGCACAGAGACTCTCCAAAGTCAACAAGT
ACATCTGTGAAAAAATCATGGATATCAATAAATCCTGTAAAAATGAAGAACGAAGGGAAGCAAAATACAATTTGCAATAAACTTTGGATT
TTTCATAAAGCTTTCGTGTTTTCCTTGTGTGGCATGTGATTTGCGAGCGATGGTGCCGTCCAAATCAGACCCCACCGTGCATGGTGGTGT
GTGTGCAGGGATCCATCGGGTTCTGGGGTCAGCGGCTTGTTCTGAATGTGGACACTCCAAAGACGACAGATGGCTTTGCTGAGACTCAGG
AGCAGCCTGGCACTGGTGTCCTTCTGGGAATGGGGAAAACACTCTTCTTGGAGGGGGATAAGGTTGCCTGAGTTGCCTGTCACTTGACTG

>In-frame_ARID1A_ENST00000457599_chr1_27024031_+_BEND5_ENST00000371833_chr1_49202124_-_1872nt
ATGGCCGCGCAGGTCGCCCCCGCCGCCGCCAGCAGCCTGGGCAACCCGCCGCCGCCGCCGCCCTCGGAGCTGAAGAAAGCCGAGCAGCAG
CAGCGGGAGGAGGCGGGGGGCGAGGCGGCGGCGGCGGCAGCGGCCGAGCGCGGGGAAATGAAGGCAGCCGCCGGGCAGGAAAGCGAGGGC
CCCGCCGTGGGGCCGCCGCAGCCGCTGGGAAAGGAGCTGCAGGACGGGGCCGAGAGCAATGGGGGTGGCGGCGGCGGCGGAGCCGGCAGC
GGCGGCGGGCCCGGCGCGGAGCCGGACCTGAAGAACTCGAACGGGAACGCGGGCCCTAGGCCCGCCCTGAACAATAACCTCACGGAGCCG
CCCGGCGGCGGCGGTGGCGGCAGCAGCGATGGGGTGGGGGCGCCTCCTCACTCAGCCGCGGCCGCCTTGCCGCCCCCAGCCTACGGCTTC
GGGCAACCCTACGGCCGGAGCCCGTCTGCCGTCGCCGCCGCCGCGGCCGCCGTCTTCCACCAACAACATGGCGGACAACAAAGCCCTGGC
CTGGCAGCGCTGCAGAGCGGCGGCGGCGGGGGCCTGGAGCCCTACGCGGGGCCCCAGCAGAACTCTCACGACCACGGCTTCCCCAACCAC
CAGTACAACTCCTACTACCCCAACCGCAGCGCCTACCCCCCGCCCGCCCCGGCCTACGCGCTGAGCTCCCCGAGAGGTGGCACTCCGGGC
TCCGGCGCGGCGGCGGCTGCCGGCTCCAAGCCGCCTCCCTCCTCCAGCGCCTCCGCCTCCTCGTCGTCTTCGTCCTTCGCTCAGCAGCGC
TTCGGGGCCATGGGGGGAGGCGGCCCCTCCGCGGCCGGCGGGGGAACTCCCCAGCCCACCGCCACCCCCACCCTCAACCAACTGCTCACG
TCGCCCAGCTCGGCCCGGGGCTACCAGGGCTACCCCGGGGGCGACTACAGTGGCGGGCCCCAGGACGGGGGCGCCGGCAAGGGCCCGGCG
GACATGGCCTCGCAGTGTTGGGGGGCTGCGGCGGCGGCAGCTGCGGCGGCGGCCGCCTCGGGAGGGGCCCAACAAAGGAGCCACCACGCG
CCCATGAGCCCCGGGAGCAGCGGCGGCGGGGGGCAGCCGCTCGCCCGGACCCCTCAGGTCCATCTGGGAAGCGGGATTTGGGTTGATGAG
GAGAAATGGCACCAGCTACAAGTAACCCAAGGAGATTCCAAGTACACGAAGAACTTGGCAGTTATGATTTGGGGAACAGATGTTCTGAAA
AACAGAAGCGTCACAGGCGTCGCCACAAAAAAAAAGAAAGATGCAGTCCCTAAACCACCCCTCTCGCCTCACAAACTAAGCATCGTCAGA
GAGTGTTTGTATGACAGAATAGCACAAGAAACTGTGGATGAAACTGAAATTGCACAGAGACTCTCCAAAGTCAACAAGTACATCTGTGAA
AAAATCATGGATATCAATAAATCCTGTAAAAATGAAGAACGAAGGGAAGCAAAATACAATTTGCAATAAACTTTGGATTTTTCATAAAGC
TTTCGTGTTTTCCTTGTGTGGCATGTGATTTGCGAGCGATGGTGCCGTCCAAATCAGACCCCACCGTGCATGGTGGTGTGTGTGCAGGGA
TCCATCGGGTTCTGGGGTCAGCGGCTTGTTCTGAATGTGGACACTCCAAAGACGACAGATGGCTTTGCTGAGACTCAGGAGCAGCCTGGC
ACTGGTGTCCTTCTGGGAATGGGGAAAACACTCTTCTTGGAGGGGGATAAGGTTGCCTGAGTTGCCTGTCACTTGACTGGGGTTTGAATG


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FusionGenePPI for ARID1A_BEND5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ARID1AKLF1, GATA1, SMARCB1, SMARCA4, SMARCA2, ING1, SMARCE1, PBRM1, SMARCC2, SMARCC1, PGR, BCL7C, HIC1, CUL2, ARID1B, SMAD2, SMAD3, CARM1, ADNP, RARA, SOX2, CHD7, SMARCD1, TP53, ELAVL1, SIRT7, TFAP4, CUL3, SMARCD2, ACTL6A, SMARCD3, PHF10, ECT2, YAP1, ITCH, NEDD4, SHMT2, MOV10, NXF1, EED, DPF3, DPF2, SS18, UNK, BCL7A, BCL7B, ESR1, NCOA1, RARB, RARG, EWSR1, SNW1, CDC5L, CUL1, SKP1, NFATC1, NFATC2, TOP1, CHEK1, VHL, EYA2, NR3C1, AR, ALDH2, TRIM25BEND5GRAP2, USP2, CTNNBIP1, GFI1B, USP7, APP, BZRAP1, PRKAB2, UBE2I, EIF3D, BUD31, USP20, GORASP2, FAM161A, VPS25, ZGPAT, ZNF417, RTP5, LCE1B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ARID1A_BEND5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ARID1A_BEND5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARID1AC0038356Stomach Neoplasms3CTD_human
HgeneARID1AC2239176Liver carcinoma3CTD_human
HgeneARID1AC0001418Adenocarcinoma1CTD_human
HgeneARID1AC0005695Bladder Neoplasm1CTD_human
HgeneARID1AC0006413Burkitt Lymphoma1CTD_human
HgeneARID1AC0007138Carcinoma, Transitional Cell1CTD_human
HgeneARID1AC0010606Adenoid Cystic Carcinoma1CTD_human
HgeneARID1AC0014170Endometrial Neoplasms1CTD_human
HgeneARID1AC0027819Neuroblastoma1CTD_human
HgeneARID1AC0036920Sezary Syndrome1CTD_human
HgeneARID1AC0079772T-Cell Lymphoma1CTD_human
HgeneARID1AC0079773Lymphoma, T-Cell, Cutaneous1CTD_human
HgeneARID1AC0206698Cholangiocarcinoma1CTD_human
HgeneARID1AC0265338Coffin-Siris syndrome1CTD_human;ORPHANET
HgeneARID1AC0279628Adenocarcinoma Of Esophagus1CTD_human
HgeneARID1AC0920269Microsatellite Instability1CTD_human
HgeneARID1AC2931822Nasopharyngeal carcinoma1CTD_human