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Fusion gene ID: 26027 |
FusionGeneSummary for PARP14_SLC44A5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PARP14_SLC44A5 | Fusion gene ID: 26027 | Hgene | Tgene | Gene symbol | PARP14 | SLC44A5 | Gene ID | 54625 | 204962 |
| Gene name | poly(ADP-ribose) polymerase family member 14 | solute carrier family 44 member 5 | |
| Synonyms | ARTD8|BAL2|PARP-14|pART8 | CTL5 | |
| Cytomap | 3q21.1 | 1p31.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | poly [ADP-ribose] polymerase 14ADP-ribosyltransferase diphtheria toxin-like 8B-aggressive lymphoma 2b aggressive lymphoma protein 2collaborator of STAT6 | choline transporter-like protein 5 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q460N5 | Q8NCS7 | |
| Ensembl transtripts involved in fusion gene | ENST00000474629, ENST00000475640, | ENST00000370859, ENST00000370855, ENST00000535611, ENST00000469525, | |
| Fusion gene scores | * DoF score | 6 X 7 X 3=126 | 4 X 4 X 2=32 |
| # samples | 8 | 5 | |
| ** MAII score | log2(8/126*10)=-0.655351828612554 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/32*10)=0.643856189774725 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PARP14 [Title/Abstract] AND SLC44A5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PARP14 | GO:0006471 | protein ADP-ribosylation | 27796300 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AI634522 | PARP14 | chr3 | 122449678 | + | SLC44A5 | chr1 | 76135444 | + | ||
| ChiTaRS3.1 | AI702633 | PARP14 | chr3 | 122449678 | + | SLC44A5 | chr1 | 76135444 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-intron | ENST00000474629 | ENST00000370859 | PARP14 | chr3 | 122449678 | + | SLC44A5 | chr1 | 76135444 | + |
| 3UTR-intron | ENST00000474629 | ENST00000370855 | PARP14 | chr3 | 122449678 | + | SLC44A5 | chr1 | 76135444 | + |
| 3UTR-intron | ENST00000474629 | ENST00000535611 | PARP14 | chr3 | 122449678 | + | SLC44A5 | chr1 | 76135444 | + |
| 3UTR-intron | ENST00000474629 | ENST00000469525 | PARP14 | chr3 | 122449678 | + | SLC44A5 | chr1 | 76135444 | + |
| intron-intron | ENST00000475640 | ENST00000370859 | PARP14 | chr3 | 122449678 | + | SLC44A5 | chr1 | 76135444 | + |
| intron-intron | ENST00000475640 | ENST00000370855 | PARP14 | chr3 | 122449678 | + | SLC44A5 | chr1 | 76135444 | + |
| intron-intron | ENST00000475640 | ENST00000535611 | PARP14 | chr3 | 122449678 | + | SLC44A5 | chr1 | 76135444 | + |
| intron-intron | ENST00000475640 | ENST00000469525 | PARP14 | chr3 | 122449678 | + | SLC44A5 | chr1 | 76135444 | + |
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FusionProtFeatures for PARP14_SLC44A5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PARP14 | SLC44A5 |