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Fusion gene ID: 25980 |
FusionGeneSummary for PARD3_LYAR |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PARD3_LYAR | Fusion gene ID: 25980 | Hgene | Tgene | Gene symbol | PARD3 | LYAR | Gene ID | 56288 | 55646 |
| Gene name | par-3 family cell polarity regulator | Ly1 antibody reactive | |
| Synonyms | ASIP|Baz|PAR3|PAR3alpha|PARD-3|PARD3A|PPP1R118|SE2-5L16|SE2-5LT1|SE2-5T2 | ZC2HC2|ZLYAR | |
| Cytomap | 10p11.22-p11.21 | 4p16.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | partitioning defective 3 homologCTCL tumor antigen se2-5PAR3-alphaatypical PKC isotype-specific interacting proteinbazookapar-3 family cell polarity regulator alphapar-3 partitioning defective 3 homologprotein phosphatase 1, regulatory subunit 118 | cell growth-regulating nucleolar proteinLy1 antibody reactive homolog | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q8TEW0 | Q9NX58 | |
| Ensembl transtripts involved in fusion gene | ENST00000545260, ENST00000545693, ENST00000350537, ENST00000346874, ENST00000374789, ENST00000374790, ENST00000374794, ENST00000374788, ENST00000466092, ENST00000374776, ENST00000340077, ENST00000544292, ENST00000374773, ENST00000374768, | ENST00000343470, ENST00000452476, | |
| Fusion gene scores | * DoF score | 22 X 13 X 12=3432 | 6 X 5 X 4=120 |
| # samples | 26 | 7 | |
| ** MAII score | log2(26/3432*10)=-3.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PARD3 [Title/Abstract] AND LYAR [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LGG | TCGA-DH-A669-02A | PARD3 | chr10 | 35103804 | - | LYAR | chr4 | 4276496 | - |
| TCGA | RV | LGG | TCGA-DH-A669-01A | PARD3 | chr10 | 35103804 | - | LYAR | chr4 | 4276496 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000545260 | ENST00000343470 | PARD3 | chr10 | 35103804 | - | LYAR | chr4 | 4276496 | - |
| In-frame | ENST00000545260 | ENST00000452476 | PARD3 | chr10 | 35103804 | - | LYAR | chr4 | 4276496 | - |
| In-frame | ENST00000545693 | ENST00000343470 | PARD3 | chr10 | 35103804 | - | LYAR | chr4 | 4276496 | - |
| In-frame | ENST00000545693 | ENST00000452476 | PARD3 | chr10 | 35103804 | - | LYAR | chr4 | 4276496 | - |
| In-frame | ENST00000350537 | ENST00000343470 | PARD3 | chr10 | 35103804 | - | LYAR | chr4 | 4276496 | - |
| In-frame | ENST00000350537 | ENST00000452476 | PARD3 | chr10 | 35103804 | - | LYAR | chr4 | 4276496 | - |
| In-frame | ENST00000346874 | ENST00000343470 | PARD3 | chr10 | 35103804 | - | LYAR | chr4 | 4276496 | - |
| In-frame | ENST00000346874 | ENST00000452476 | PARD3 | chr10 | 35103804 | - | LYAR | chr4 | 4276496 | - |
| In-frame | ENST00000374789 | ENST00000343470 | PARD3 | chr10 | 35103804 | - | LYAR | chr4 | 4276496 | - |
| In-frame | ENST00000374789 | ENST00000452476 | PARD3 | chr10 | 35103804 | - | LYAR | chr4 | 4276496 | - |
| In-frame | ENST00000374790 | ENST00000343470 | PARD3 | chr10 | 35103804 | - | LYAR | chr4 | 4276496 | - |
| In-frame | ENST00000374790 | ENST00000452476 | PARD3 | chr10 | 35103804 | - | LYAR | chr4 | 4276496 | - |
| In-frame | ENST00000374794 | ENST00000343470 | PARD3 | chr10 | 35103804 | - | LYAR | chr4 | 4276496 | - |
| In-frame | ENST00000374794 | ENST00000452476 | PARD3 | chr10 | 35103804 | - | LYAR | chr4 | 4276496 | - |
| In-frame | ENST00000374788 | ENST00000343470 | PARD3 | chr10 | 35103804 | - | LYAR | chr4 | 4276496 | - |
| In-frame | ENST00000374788 | ENST00000452476 | PARD3 | chr10 | 35103804 | - | LYAR | chr4 | 4276496 | - |
| intron-3CDS | ENST00000466092 | ENST00000343470 | PARD3 | chr10 | 35103804 | - | LYAR | chr4 | 4276496 | - |
| intron-3CDS | ENST00000466092 | ENST00000452476 | PARD3 | chr10 | 35103804 | - | LYAR | chr4 | 4276496 | - |
| In-frame | ENST00000374776 | ENST00000343470 | PARD3 | chr10 | 35103804 | - | LYAR | chr4 | 4276496 | - |
| In-frame | ENST00000374776 | ENST00000452476 | PARD3 | chr10 | 35103804 | - | LYAR | chr4 | 4276496 | - |
| In-frame | ENST00000340077 | ENST00000343470 | PARD3 | chr10 | 35103804 | - | LYAR | chr4 | 4276496 | - |
| In-frame | ENST00000340077 | ENST00000452476 | PARD3 | chr10 | 35103804 | - | LYAR | chr4 | 4276496 | - |
| intron-3CDS | ENST00000544292 | ENST00000343470 | PARD3 | chr10 | 35103804 | - | LYAR | chr4 | 4276496 | - |
| intron-3CDS | ENST00000544292 | ENST00000452476 | PARD3 | chr10 | 35103804 | - | LYAR | chr4 | 4276496 | - |
| In-frame | ENST00000374773 | ENST00000343470 | PARD3 | chr10 | 35103804 | - | LYAR | chr4 | 4276496 | - |
| In-frame | ENST00000374773 | ENST00000452476 | PARD3 | chr10 | 35103804 | - | LYAR | chr4 | 4276496 | - |
| intron-3CDS | ENST00000374768 | ENST00000343470 | PARD3 | chr10 | 35103804 | - | LYAR | chr4 | 4276496 | - |
| intron-3CDS | ENST00000374768 | ENST00000452476 | PARD3 | chr10 | 35103804 | - | LYAR | chr4 | 4276496 | - |
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FusionProtFeatures for PARD3_LYAR |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PARD3 | LYAR |