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Fusion gene ID: 2597

FusionGeneSummary for ARHGEF7_SPATA7

Fusion gene summary

Fusion gene information	Fusion gene name: ARHGEF7_SPATA7
	Fusion gene ID: 2597
		Hgene	Tgene
	Gene symbol	ARHGEF7	SPATA7
	Gene ID	8874	55812
	Gene name	Rho guanine nucleotide exchange factor 7	spermatogenesis associated 7
	Synonyms	BETA-PIX\|COOL-1\|COOL1\|Nbla10314\|P50\|P50BP\|P85\|P85COOL1\|P85SPR\|PAK3\|PIXB	HEL-S-296\|HSD-3.1\|HSD3\|LCA3
	Cytomap	13q34	14q31.3
	Type of gene	protein-coding	protein-coding
	Description	rho guanine nucleotide exchange factor 7PAK-interacting exchange factor betaRho guanine nucleotide exchange factor (GEF) 7SH3 domain-containing proline-rich protein	spermatogenesis-associated protein 7epididymis secretory protein Li 296spermatogenesis-associated protein HSD3
	Modification date	20180522	20180519
	UniProtAcc	Q14155	Q9P0W8
	Ensembl transtripts involved in fusion gene	ENST00000317133, ENST00000375741, ENST00000375739, ENST00000370623, ENST00000544132, ENST00000218789, ENST00000375736, ENST00000426073, ENST00000375737, ENST00000375723, ENST00000478679, ENST00000483189,	ENST00000556553, ENST00000393545, ENST00000356583, ENST00000554102, ENST00000045347,
Fusion gene scores	* DoF score	11 X 9 X 7=693	2 X 2 X 2=8
	# samples	11	2
	** MAII score	log2(11/693*10)=-2.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: ARHGEF7 [Title/Abstract] AND SPATA7 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ARHGEF7	GO:0043547	positive regulation of GTPase activity	21048939

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	SARC	TCGA-SI-A71O-06A	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000317133	ENST00000556553	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
In-frame	ENST00000317133	ENST00000393545	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
In-frame	ENST00000317133	ENST00000356583	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
5CDS-intron	ENST00000317133	ENST00000554102	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
5CDS-intron	ENST00000317133	ENST00000045347	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
In-frame	ENST00000375741	ENST00000556553	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
In-frame	ENST00000375741	ENST00000393545	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
In-frame	ENST00000375741	ENST00000356583	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
5CDS-intron	ENST00000375741	ENST00000554102	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
5CDS-intron	ENST00000375741	ENST00000045347	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
In-frame	ENST00000375739	ENST00000556553	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
In-frame	ENST00000375739	ENST00000393545	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
In-frame	ENST00000375739	ENST00000356583	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
5CDS-intron	ENST00000375739	ENST00000554102	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
5CDS-intron	ENST00000375739	ENST00000045347	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
In-frame	ENST00000370623	ENST00000556553	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
In-frame	ENST00000370623	ENST00000393545	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
In-frame	ENST00000370623	ENST00000356583	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
5CDS-intron	ENST00000370623	ENST00000554102	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
5CDS-intron	ENST00000370623	ENST00000045347	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
intron-3CDS	ENST00000544132	ENST00000556553	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
intron-3CDS	ENST00000544132	ENST00000393545	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
intron-3CDS	ENST00000544132	ENST00000356583	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
intron-intron	ENST00000544132	ENST00000554102	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
intron-intron	ENST00000544132	ENST00000045347	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
In-frame	ENST00000218789	ENST00000556553	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
In-frame	ENST00000218789	ENST00000393545	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
In-frame	ENST00000218789	ENST00000356583	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
5CDS-intron	ENST00000218789	ENST00000554102	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
5CDS-intron	ENST00000218789	ENST00000045347	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
In-frame	ENST00000375736	ENST00000556553	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
In-frame	ENST00000375736	ENST00000393545	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
In-frame	ENST00000375736	ENST00000356583	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
5CDS-intron	ENST00000375736	ENST00000554102	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
5CDS-intron	ENST00000375736	ENST00000045347	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
In-frame	ENST00000426073	ENST00000556553	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
In-frame	ENST00000426073	ENST00000393545	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
In-frame	ENST00000426073	ENST00000356583	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
5CDS-intron	ENST00000426073	ENST00000554102	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
5CDS-intron	ENST00000426073	ENST00000045347	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
In-frame	ENST00000375737	ENST00000556553	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
In-frame	ENST00000375737	ENST00000393545	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
In-frame	ENST00000375737	ENST00000356583	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
5CDS-intron	ENST00000375737	ENST00000554102	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
5CDS-intron	ENST00000375737	ENST00000045347	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
In-frame	ENST00000375723	ENST00000556553	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
In-frame	ENST00000375723	ENST00000393545	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
In-frame	ENST00000375723	ENST00000356583	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
5CDS-intron	ENST00000375723	ENST00000554102	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
5CDS-intron	ENST00000375723	ENST00000045347	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
In-frame	ENST00000478679	ENST00000556553	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
In-frame	ENST00000478679	ENST00000393545	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
In-frame	ENST00000478679	ENST00000356583	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
5CDS-intron	ENST00000478679	ENST00000554102	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
5CDS-intron	ENST00000478679	ENST00000045347	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
intron-3CDS	ENST00000483189	ENST00000556553	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
intron-3CDS	ENST00000483189	ENST00000393545	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
intron-3CDS	ENST00000483189	ENST00000356583	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
intron-intron	ENST00000483189	ENST00000554102	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+
intron-intron	ENST00000483189	ENST00000045347	ARHGEF7	chr13	111940790	+	SPATA7	chr14	88883055	+

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FusionProtFeatures for ARHGEF7_SPATA7

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ARHGEF7 Q14155	SPATA7 Q9P0W8

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Fusion gene ID: 2597

FusionGeneSummary for ARHGEF7_SPATA7

FusionProtFeatures for ARHGEF7_SPATA7