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Fusion gene ID: 25946 |
FusionGeneSummary for PAPSS1_RAB13 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PAPSS1_RAB13 | Fusion gene ID: 25946 | Hgene | Tgene | Gene symbol | PAPSS1 | RAB13 | Gene ID | 9061 | 5872 |
| Gene name | 3'-phosphoadenosine 5'-phosphosulfate synthase 1 | RAB13, member RAS oncogene family | |
| Synonyms | ATPSK1|PAPSS|SK1 | GIG4 | |
| Cytomap | 4q25 | 1q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 13-prime-phosphoadenosine 5-prime-phosphosulfate synthase 1PAPS synthase 1PAPSS 1SK 1adenylyl-sulfate kinasesulfate adenylyltransferasesulfurylase kinase 1 | ras-related protein Rab-13RAS-associated protein RAB13cell growth-inhibiting gene 4 proteingrowth-inhibiting gene 4 protein | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O43252 | P51153 | |
| Ensembl transtripts involved in fusion gene | ENST00000265174, ENST00000511304, | ENST00000368575, ENST00000462680, | |
| Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 6 X 4 X 4=96 |
| # samples | 4 | 6 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PAPSS1 [Title/Abstract] AND RAB13 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PAPSS1 | GO:0000103 | sulfate assimilation | 14747722 |
| Hgene | PAPSS1 | GO:0050428 | 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process | 14747722|23207770 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DA811913 | PAPSS1 | chr4 | 108603212 | - | RAB13 | chr1 | 153958815 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000265174 | ENST00000368575 | PAPSS1 | chr4 | 108603212 | - | RAB13 | chr1 | 153958815 | - |
| intron-intron | ENST00000265174 | ENST00000462680 | PAPSS1 | chr4 | 108603212 | - | RAB13 | chr1 | 153958815 | - |
| intron-5UTR | ENST00000511304 | ENST00000368575 | PAPSS1 | chr4 | 108603212 | - | RAB13 | chr1 | 153958815 | - |
| intron-intron | ENST00000511304 | ENST00000462680 | PAPSS1 | chr4 | 108603212 | - | RAB13 | chr1 | 153958815 | - |
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FusionProtFeatures for PAPSS1_RAB13 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PAPSS1 | RAB13 |