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Fusion gene ID: 25901 |
FusionGeneSummary for PANK4_TMEM178B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PANK4_TMEM178B | Fusion gene ID: 25901 | Hgene | Tgene | Gene symbol | PANK4 | TMEM178B | Gene ID | 55229 | 100507421 |
| Gene name | pantothenate kinase 4 | transmembrane protein 178B | |
| Synonyms | - | - | |
| Cytomap | 1p36.32 | 7q34 | |
| Type of gene | protein-coding | protein-coding | |
| Description | pantothenate kinase 4hPanK4pantothenic acid kinase 4 | transmembrane protein 178B | |
| Modification date | 20180519 | 20180329 | |
| UniProtAcc | Q9NVE7 | H3BS89 | |
| Ensembl transtripts involved in fusion gene | ENST00000378466, ENST00000435556, ENST00000491212, | ENST00000565468, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 3 X 2=18 |
| # samples | 2 | 4 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PANK4 [Title/Abstract] AND TMEM178B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BU857222 | PANK4 | chr1 | 2439979 | - | TMEM178B | chr7 | 141012933 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000378466 | ENST00000565468 | PANK4 | chr1 | 2439979 | - | TMEM178B | chr7 | 141012933 | - |
| 5CDS-intron | ENST00000435556 | ENST00000565468 | PANK4 | chr1 | 2439979 | - | TMEM178B | chr7 | 141012933 | - |
| intron-intron | ENST00000491212 | ENST00000565468 | PANK4 | chr1 | 2439979 | - | TMEM178B | chr7 | 141012933 | - |
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FusionProtFeatures for PANK4_TMEM178B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PANK4 | TMEM178B |