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Fusion gene ID: 25890 |
FusionGeneSummary for PANK2_HSPA12B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PANK2_HSPA12B | Fusion gene ID: 25890 | Hgene | Tgene | Gene symbol | PANK2 | HSPA12B | Gene ID | 80025 | 116835 |
| Gene name | pantothenate kinase 2 | heat shock protein family A (Hsp70) member 12B | |
| Synonyms | C20orf48|HARP|HSS|NBIA1|PKAN | C20orf60 | |
| Cytomap | 20p13 | 20p13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | pantothenate kinase 2, mitochondrialHallervorden-Spatz syndromepantothenic acid kinase 2 | heat shock 70 kDa protein 12B | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | Q9BZ23 | Q96MM6 | |
| Ensembl transtripts involved in fusion gene | ENST00000497424, ENST00000316562, ENST00000610179, ENST00000464452, | ENST00000254963, ENST00000542646, | |
| Fusion gene scores | * DoF score | 6 X 4 X 4=96 | 3 X 3 X 3=27 |
| # samples | 6 | 3 | |
| ** MAII score | log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PANK2 [Title/Abstract] AND HSPA12B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-23-1123-01A | PANK2 | chr20 | 3870375 | + | HSPA12B | chr20 | 3719305 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000497424 | ENST00000254963 | PANK2 | chr20 | 3870375 | + | HSPA12B | chr20 | 3719305 | + |
| intron-5UTR | ENST00000497424 | ENST00000542646 | PANK2 | chr20 | 3870375 | + | HSPA12B | chr20 | 3719305 | + |
| 5CDS-5UTR | ENST00000316562 | ENST00000254963 | PANK2 | chr20 | 3870375 | + | HSPA12B | chr20 | 3719305 | + |
| 5CDS-5UTR | ENST00000316562 | ENST00000542646 | PANK2 | chr20 | 3870375 | + | HSPA12B | chr20 | 3719305 | + |
| 5CDS-5UTR | ENST00000610179 | ENST00000254963 | PANK2 | chr20 | 3870375 | + | HSPA12B | chr20 | 3719305 | + |
| 5CDS-5UTR | ENST00000610179 | ENST00000542646 | PANK2 | chr20 | 3870375 | + | HSPA12B | chr20 | 3719305 | + |
| intron-5UTR | ENST00000464452 | ENST00000254963 | PANK2 | chr20 | 3870375 | + | HSPA12B | chr20 | 3719305 | + |
| intron-5UTR | ENST00000464452 | ENST00000542646 | PANK2 | chr20 | 3870375 | + | HSPA12B | chr20 | 3719305 | + |
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FusionProtFeatures for PANK2_HSPA12B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PANK2 | HSPA12B |