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Fusion gene ID: 25857

FusionGeneSummary for PALLD_SRSF4

Fusion gene summary

Fusion gene information	Fusion gene name: PALLD_SRSF4
	Fusion gene ID: 25857
		Hgene	Tgene
	Gene symbol	PALLD	SRSF4
	Gene ID	23022	6429
	Gene name	palladin, cytoskeletal associated protein	serine and arginine rich splicing factor 4
	Synonyms	CGI-151\|CGI151\|MYN\|PNCA1\|SIH002	SFRS4\|SRP75
	Cytomap	4q32.3	1p35.3
	Type of gene	protein-coding	protein-coding
	Description	palladinmyoneurinsarcoma antigen NY-SAR-77	serine/arginine-rich splicing factor 4SR splicing factor 4SRP001LBpre-mRNA-splicing factor SRP75splicing factor, arginine/serine-rich 4
	Modification date	20180523	20180523
	UniProtAcc	Q8WX93	Q08170
	Ensembl transtripts involved in fusion gene	ENST00000335742, ENST00000261509, ENST00000505667, ENST00000333488, ENST00000512127, ENST00000507735,	ENST00000373795, ENST00000546138, ENST00000466448,
Fusion gene scores	* DoF score	8 X 7 X 4=224	6 X 6 X 2=72
	# samples	8	6
	** MAII score	log2(8/224*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PALLD [Title/Abstract] AND SRSF4 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	SRSF4	GO:0048025	negative regulation of mRNA splicing, via spliceosome	15009664

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BQ313599	PALLD	chr4	169567689	-	SRSF4	chr1	29506065	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000335742	ENST00000373795	PALLD	chr4	169567689	-	SRSF4	chr1	29506065	+
intron-intron	ENST00000335742	ENST00000546138	PALLD	chr4	169567689	-	SRSF4	chr1	29506065	+
intron-intron	ENST00000335742	ENST00000466448	PALLD	chr4	169567689	-	SRSF4	chr1	29506065	+
intron-intron	ENST00000261509	ENST00000373795	PALLD	chr4	169567689	-	SRSF4	chr1	29506065	+
intron-intron	ENST00000261509	ENST00000546138	PALLD	chr4	169567689	-	SRSF4	chr1	29506065	+
intron-intron	ENST00000261509	ENST00000466448	PALLD	chr4	169567689	-	SRSF4	chr1	29506065	+
intron-intron	ENST00000505667	ENST00000373795	PALLD	chr4	169567689	-	SRSF4	chr1	29506065	+
intron-intron	ENST00000505667	ENST00000546138	PALLD	chr4	169567689	-	SRSF4	chr1	29506065	+
intron-intron	ENST00000505667	ENST00000466448	PALLD	chr4	169567689	-	SRSF4	chr1	29506065	+
intron-intron	ENST00000333488	ENST00000373795	PALLD	chr4	169567689	-	SRSF4	chr1	29506065	+
intron-intron	ENST00000333488	ENST00000546138	PALLD	chr4	169567689	-	SRSF4	chr1	29506065	+
intron-intron	ENST00000333488	ENST00000466448	PALLD	chr4	169567689	-	SRSF4	chr1	29506065	+
intron-intron	ENST00000512127	ENST00000373795	PALLD	chr4	169567689	-	SRSF4	chr1	29506065	+
intron-intron	ENST00000512127	ENST00000546138	PALLD	chr4	169567689	-	SRSF4	chr1	29506065	+
intron-intron	ENST00000512127	ENST00000466448	PALLD	chr4	169567689	-	SRSF4	chr1	29506065	+
intron-intron	ENST00000507735	ENST00000373795	PALLD	chr4	169567689	-	SRSF4	chr1	29506065	+
intron-intron	ENST00000507735	ENST00000546138	PALLD	chr4	169567689	-	SRSF4	chr1	29506065	+
intron-intron	ENST00000507735	ENST00000466448	PALLD	chr4	169567689	-	SRSF4	chr1	29506065	+

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FusionProtFeatures for PALLD_SRSF4

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
PALLD Q8WX93	SRSF4 Q08170

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Fusion gene ID: 25857

FusionGeneSummary for PALLD_SRSF4

FusionProtFeatures for PALLD_SRSF4