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Fusion gene ID: 25838 |
FusionGeneSummary for PAK4_B9D1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PAK4_B9D1 | Fusion gene ID: 25838 | Hgene | Tgene | Gene symbol | PAK4 | B9D1 | Gene ID | 10298 | 27077 |
| Gene name | p21 (RAC1) activated kinase 4 | B9 domain containing 1 | |
| Synonyms | - | B9|EPPB9|JBTS27|MKS9|MKSR1 | |
| Cytomap | 19q13.2 | 17p11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase PAK 4p21 protein (Cdc42/Rac)-activated kinase 4p21(CDKN1A)-activated kinase 4protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs | B9 domain-containing protein 1B9 protein domain 1MKS1-related protein 1endothelial precursor protein B9 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | O96013 | Q9UPM9 | |
| Ensembl transtripts involved in fusion gene | ENST00000599470, ENST00000321944, ENST00000358301, ENST00000597766, ENST00000593690, ENST00000599386, ENST00000435673, ENST00000360442, | ENST00000575403, ENST00000477478, ENST00000468679, ENST00000461069, ENST00000395615, ENST00000261499, ENST00000395616, ENST00000268841, | |
| Fusion gene scores | * DoF score | 13 X 4 X 6=312 | 3 X 2 X 3=18 |
| # samples | 13 | 3 | |
| ** MAII score | log2(13/312*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PAK4 [Title/Abstract] AND B9D1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PAAD | TCGA-L1-A7W4-01A | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000599470 | ENST00000575403 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 5UTR-3CDS | ENST00000599470 | ENST00000477478 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 5UTR-intron | ENST00000599470 | ENST00000468679 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 5UTR-intron | ENST00000599470 | ENST00000461069 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 5UTR-intron | ENST00000599470 | ENST00000395615 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 5UTR-intron | ENST00000599470 | ENST00000261499 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 5UTR-intron | ENST00000599470 | ENST00000395616 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 5UTR-intron | ENST00000599470 | ENST00000268841 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 5UTR-3CDS | ENST00000321944 | ENST00000575403 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 5UTR-3CDS | ENST00000321944 | ENST00000477478 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 5UTR-intron | ENST00000321944 | ENST00000468679 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 5UTR-intron | ENST00000321944 | ENST00000461069 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 5UTR-intron | ENST00000321944 | ENST00000395615 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 5UTR-intron | ENST00000321944 | ENST00000261499 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 5UTR-intron | ENST00000321944 | ENST00000395616 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 5UTR-intron | ENST00000321944 | ENST00000268841 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 5UTR-3CDS | ENST00000358301 | ENST00000575403 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 5UTR-3CDS | ENST00000358301 | ENST00000477478 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 5UTR-intron | ENST00000358301 | ENST00000468679 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 5UTR-intron | ENST00000358301 | ENST00000461069 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 5UTR-intron | ENST00000358301 | ENST00000395615 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 5UTR-intron | ENST00000358301 | ENST00000261499 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 5UTR-intron | ENST00000358301 | ENST00000395616 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 5UTR-intron | ENST00000358301 | ENST00000268841 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 3UTR-3CDS | ENST00000597766 | ENST00000575403 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 3UTR-3CDS | ENST00000597766 | ENST00000477478 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 3UTR-intron | ENST00000597766 | ENST00000468679 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 3UTR-intron | ENST00000597766 | ENST00000461069 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 3UTR-intron | ENST00000597766 | ENST00000395615 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 3UTR-intron | ENST00000597766 | ENST00000261499 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 3UTR-intron | ENST00000597766 | ENST00000395616 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 3UTR-intron | ENST00000597766 | ENST00000268841 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 5UTR-3CDS | ENST00000593690 | ENST00000575403 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 5UTR-3CDS | ENST00000593690 | ENST00000477478 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 5UTR-intron | ENST00000593690 | ENST00000468679 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 5UTR-intron | ENST00000593690 | ENST00000461069 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 5UTR-intron | ENST00000593690 | ENST00000395615 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 5UTR-intron | ENST00000593690 | ENST00000261499 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 5UTR-intron | ENST00000593690 | ENST00000395616 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 5UTR-intron | ENST00000593690 | ENST00000268841 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 5UTR-3CDS | ENST00000599386 | ENST00000575403 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 5UTR-3CDS | ENST00000599386 | ENST00000477478 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 5UTR-intron | ENST00000599386 | ENST00000468679 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 5UTR-intron | ENST00000599386 | ENST00000461069 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 5UTR-intron | ENST00000599386 | ENST00000395615 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 5UTR-intron | ENST00000599386 | ENST00000261499 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 5UTR-intron | ENST00000599386 | ENST00000395616 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| 5UTR-intron | ENST00000599386 | ENST00000268841 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| intron-3CDS | ENST00000435673 | ENST00000575403 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| intron-3CDS | ENST00000435673 | ENST00000477478 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| intron-intron | ENST00000435673 | ENST00000468679 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| intron-intron | ENST00000435673 | ENST00000461069 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| intron-intron | ENST00000435673 | ENST00000395615 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| intron-intron | ENST00000435673 | ENST00000261499 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| intron-intron | ENST00000435673 | ENST00000395616 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| intron-intron | ENST00000435673 | ENST00000268841 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| intron-3CDS | ENST00000360442 | ENST00000575403 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| intron-3CDS | ENST00000360442 | ENST00000477478 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| intron-intron | ENST00000360442 | ENST00000468679 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| intron-intron | ENST00000360442 | ENST00000461069 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| intron-intron | ENST00000360442 | ENST00000395615 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| intron-intron | ENST00000360442 | ENST00000261499 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| intron-intron | ENST00000360442 | ENST00000395616 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
| intron-intron | ENST00000360442 | ENST00000268841 | PAK4 | chr19 | 39616559 | + | B9D1 | chr17 | 19251193 | - |
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FusionProtFeatures for PAK4_B9D1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PAK4 | B9D1 |