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Fusion gene ID: 25831 |
FusionGeneSummary for PAK2_ECE2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PAK2_ECE2 | Fusion gene ID: 25831 | Hgene | Tgene | Gene symbol | PAK2 | ECE2 | Gene ID | 5586 | 9718 |
| Gene name | protein kinase N2 | endothelin converting enzyme 2 | |
| Synonyms | PAK2|PRK2|PRKCL2|PRO2042|Pak-2|STK7 | - | |
| Cytomap | 1p22.2 | 3q27.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase N2PKN gammacardiolipin-activated protein kinase Pak2protein kinase C-like 2protein-kinase C-related kinase 2 | endothelin-converting enzyme 2 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q13177 | ||
| Ensembl transtripts involved in fusion gene | ENST00000327134, | ENST00000324557, ENST00000402825, ENST00000359140, ENST00000404464, ENST00000357474, | |
| Fusion gene scores | * DoF score | 9 X 7 X 10=630 | 4 X 4 X 4=64 |
| # samples | 13 | 4 | |
| ** MAII score | log2(13/630*10)=-2.27684020535882 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PAK2 [Title/Abstract] AND ECE2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PAK2 | GO:0006468 | protein phosphorylation | 17332740 |
| Hgene | PAK2 | GO:0010631 | epithelial cell migration | 21754995 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-66-2756-01A | PAK2 | chr3 | 196467028 | + | ECE2 | chr3 | 183975261 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000327134 | ENST00000324557 | PAK2 | chr3 | 196467028 | + | ECE2 | chr3 | 183975261 | + |
| 5UTR-3CDS | ENST00000327134 | ENST00000402825 | PAK2 | chr3 | 196467028 | + | ECE2 | chr3 | 183975261 | + |
| 5UTR-intron | ENST00000327134 | ENST00000359140 | PAK2 | chr3 | 196467028 | + | ECE2 | chr3 | 183975261 | + |
| 5UTR-intron | ENST00000327134 | ENST00000404464 | PAK2 | chr3 | 196467028 | + | ECE2 | chr3 | 183975261 | + |
| 5UTR-intron | ENST00000327134 | ENST00000357474 | PAK2 | chr3 | 196467028 | + | ECE2 | chr3 | 183975261 | + |
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FusionProtFeatures for PAK2_ECE2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PAK2 | ECE2 |