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Fusion gene ID: 25830 |
FusionGeneSummary for PAK2_DLG1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PAK2_DLG1 | Fusion gene ID: 25830 | Hgene | Tgene | Gene symbol | PAK2 | DLG1 | Gene ID | 5586 | 1739 |
| Gene name | protein kinase N2 | discs large MAGUK scaffold protein 1 | |
| Synonyms | PAK2|PRK2|PRKCL2|PRO2042|Pak-2|STK7 | DLGH1|SAP-97|SAP97|dJ1061C18.1.1|hdlg | |
| Cytomap | 1p22.2 | 3q29 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase N2PKN gammacardiolipin-activated protein kinase Pak2protein kinase C-like 2protein-kinase C-related kinase 2 | disks large homolog 1discs large homolog 1, scribble cell polarity complex componentdiscs, large homolog 1 transcript variant 6-v1discs, large homolog 1 transcript variant 6-v2presynaptic protein SAP97synapse-associated protein 97 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q13177 | Q12959 | |
| Ensembl transtripts involved in fusion gene | ENST00000327134, | ENST00000357674, ENST00000314062, ENST00000346964, ENST00000419354, ENST00000452595, ENST00000422288, ENST00000448528, ENST00000443183, ENST00000450955, ENST00000392382, ENST00000485409, | |
| Fusion gene scores | * DoF score | 9 X 7 X 10=630 | 6 X 7 X 6=252 |
| # samples | 13 | 7 | |
| ** MAII score | log2(13/630*10)=-2.27684020535882 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/252*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PAK2 [Title/Abstract] AND DLG1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PAK2 | GO:0006468 | protein phosphorylation | 17332740 |
| Hgene | PAK2 | GO:0010631 | epithelial cell migration | 21754995 |
| Tgene | DLG1 | GO:0001935 | endothelial cell proliferation | 14699157 |
| Tgene | DLG1 | GO:0007015 | actin filament organization | 14699157 |
| Tgene | DLG1 | GO:0030866 | cortical actin cytoskeleton organization | 14699157 |
| Tgene | DLG1 | GO:0042391 | regulation of membrane potential | 12970345 |
| Tgene | DLG1 | GO:0043268 | positive regulation of potassium ion transport | 12970345 |
| Tgene | DLG1 | GO:0070830 | bicellular tight junction assembly | 17332497 |
| Tgene | DLG1 | GO:0098609 | cell-cell adhesion | 14699157 |
| Tgene | DLG1 | GO:1903078 | positive regulation of protein localization to plasma membrane | 12970345 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | ESCA | TCGA-JY-A6F8-01A | PAK2 | chr3 | 196467028 | + | DLG1 | chr3 | 196921460 | - |
| TCGA | RV | OV | TCGA-25-1328-01A | PAK2 | chr3 | 196532254 | + | DLG1 | chr3 | 196888609 | - |
| TCGA | LD | OV | TCGA-25-1328-01A | PAK2 | chr3 | 196532254 | + | DLG1 | chr3 | 196876667 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000327134 | ENST00000357674 | PAK2 | chr3 | 196467028 | + | DLG1 | chr3 | 196921460 | - |
| 5UTR-3CDS | ENST00000327134 | ENST00000314062 | PAK2 | chr3 | 196467028 | + | DLG1 | chr3 | 196921460 | - |
| 5UTR-3CDS | ENST00000327134 | ENST00000346964 | PAK2 | chr3 | 196467028 | + | DLG1 | chr3 | 196921460 | - |
| 5UTR-3CDS | ENST00000327134 | ENST00000419354 | PAK2 | chr3 | 196467028 | + | DLG1 | chr3 | 196921460 | - |
| 5UTR-intron | ENST00000327134 | ENST00000452595 | PAK2 | chr3 | 196467028 | + | DLG1 | chr3 | 196921460 | - |
| 5UTR-intron | ENST00000327134 | ENST00000422288 | PAK2 | chr3 | 196467028 | + | DLG1 | chr3 | 196921460 | - |
| 5UTR-intron | ENST00000327134 | ENST00000448528 | PAK2 | chr3 | 196467028 | + | DLG1 | chr3 | 196921460 | - |
| 5UTR-intron | ENST00000327134 | ENST00000443183 | PAK2 | chr3 | 196467028 | + | DLG1 | chr3 | 196921460 | - |
| 5UTR-intron | ENST00000327134 | ENST00000450955 | PAK2 | chr3 | 196467028 | + | DLG1 | chr3 | 196921460 | - |
| 5UTR-intron | ENST00000327134 | ENST00000392382 | PAK2 | chr3 | 196467028 | + | DLG1 | chr3 | 196921460 | - |
| 5UTR-5UTR | ENST00000327134 | ENST00000485409 | PAK2 | chr3 | 196467028 | + | DLG1 | chr3 | 196921460 | - |
| 5CDS-intron | ENST00000327134 | ENST00000357674 | PAK2 | chr3 | 196532254 | + | DLG1 | chr3 | 196888609 | - |
| 5CDS-intron | ENST00000327134 | ENST00000314062 | PAK2 | chr3 | 196532254 | + | DLG1 | chr3 | 196888609 | - |
| 5CDS-intron | ENST00000327134 | ENST00000346964 | PAK2 | chr3 | 196532254 | + | DLG1 | chr3 | 196888609 | - |
| 5CDS-intron | ENST00000327134 | ENST00000419354 | PAK2 | chr3 | 196532254 | + | DLG1 | chr3 | 196888609 | - |
| 5CDS-intron | ENST00000327134 | ENST00000452595 | PAK2 | chr3 | 196532254 | + | DLG1 | chr3 | 196888609 | - |
| 5CDS-intron | ENST00000327134 | ENST00000422288 | PAK2 | chr3 | 196532254 | + | DLG1 | chr3 | 196888609 | - |
| 5CDS-intron | ENST00000327134 | ENST00000448528 | PAK2 | chr3 | 196532254 | + | DLG1 | chr3 | 196888609 | - |
| 5CDS-intron | ENST00000327134 | ENST00000443183 | PAK2 | chr3 | 196532254 | + | DLG1 | chr3 | 196888609 | - |
| 5CDS-intron | ENST00000327134 | ENST00000450955 | PAK2 | chr3 | 196532254 | + | DLG1 | chr3 | 196888609 | - |
| 5CDS-intron | ENST00000327134 | ENST00000392382 | PAK2 | chr3 | 196532254 | + | DLG1 | chr3 | 196888609 | - |
| 5CDS-intron | ENST00000327134 | ENST00000485409 | PAK2 | chr3 | 196532254 | + | DLG1 | chr3 | 196888609 | - |
| In-frame | ENST00000327134 | ENST00000357674 | PAK2 | chr3 | 196532254 | + | DLG1 | chr3 | 196876667 | - |
| 5CDS-intron | ENST00000327134 | ENST00000314062 | PAK2 | chr3 | 196532254 | + | DLG1 | chr3 | 196876667 | - |
| 5CDS-intron | ENST00000327134 | ENST00000346964 | PAK2 | chr3 | 196532254 | + | DLG1 | chr3 | 196876667 | - |
| 5CDS-intron | ENST00000327134 | ENST00000419354 | PAK2 | chr3 | 196532254 | + | DLG1 | chr3 | 196876667 | - |
| 5CDS-intron | ENST00000327134 | ENST00000452595 | PAK2 | chr3 | 196532254 | + | DLG1 | chr3 | 196876667 | - |
| 5CDS-intron | ENST00000327134 | ENST00000422288 | PAK2 | chr3 | 196532254 | + | DLG1 | chr3 | 196876667 | - |
| 5CDS-intron | ENST00000327134 | ENST00000448528 | PAK2 | chr3 | 196532254 | + | DLG1 | chr3 | 196876667 | - |
| 5CDS-intron | ENST00000327134 | ENST00000443183 | PAK2 | chr3 | 196532254 | + | DLG1 | chr3 | 196876667 | - |
| 5CDS-intron | ENST00000327134 | ENST00000450955 | PAK2 | chr3 | 196532254 | + | DLG1 | chr3 | 196876667 | - |
| 5CDS-intron | ENST00000327134 | ENST00000392382 | PAK2 | chr3 | 196532254 | + | DLG1 | chr3 | 196876667 | - |
| 5CDS-intron | ENST00000327134 | ENST00000485409 | PAK2 | chr3 | 196532254 | + | DLG1 | chr3 | 196876667 | - |
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FusionProtFeatures for PAK2_DLG1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PAK2 | DLG1 |