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Fusion gene ID: 25754 |
FusionGeneSummary for PACSIN2_LGALS1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PACSIN2_LGALS1 | Fusion gene ID: 25754 | Hgene | Tgene | Gene symbol | PACSIN2 | LGALS1 | Gene ID | 11252 | 3956 |
| Gene name | protein kinase C and casein kinase substrate in neurons 2 | galectin 1 | |
| Synonyms | SDPII | GAL1|GBP | |
| Cytomap | 22q13.2 | 22q13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein kinase C and casein kinase substrate in neurons protein 2cytoplasmic phosphoprotein PACSIN2syndapin-2syndapin-IIsyndapin2 | galectin-114 kDa laminin-binding protein14 kDa lectinHBLHLBP14HPLS-Lac lectin 1beta-galactoside-binding lectin L-14-Ibeta-galactoside-binding protein 14kDagal-1galaptinlactose-binding lectin 1lectin, galactoside-binding, soluble, 1putative MA | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q9UNF0 | P09382 | |
| Ensembl transtripts involved in fusion gene | ENST00000337959, ENST00000263246, ENST00000407585, ENST00000403744, ENST00000402229, | ENST00000215909, ENST00000489315, | |
| Fusion gene scores | * DoF score | 16 X 9 X 8=1152 | 6 X 4 X 4=96 |
| # samples | 17 | 6 | |
| ** MAII score | log2(17/1152*10)=-2.76053406530461 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PACSIN2 [Title/Abstract] AND LGALS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PACSIN2 | GO:0097320 | plasma membrane tubulation | 23596323 |
| Tgene | LGALS1 | GO:0046598 | positive regulation of viral entry into host cell | 21670307 |
| Tgene | LGALS1 | GO:2001200 | positive regulation of dendritic cell differentiation | 16116184 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-BR-8295-01A | PACSIN2 | chr22 | 43272143 | - | LGALS1 | chr22 | 38072993 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000337959 | ENST00000215909 | PACSIN2 | chr22 | 43272143 | - | LGALS1 | chr22 | 38072993 | + |
| 5CDS-3UTR | ENST00000337959 | ENST00000489315 | PACSIN2 | chr22 | 43272143 | - | LGALS1 | chr22 | 38072993 | + |
| Frame-shift | ENST00000263246 | ENST00000215909 | PACSIN2 | chr22 | 43272143 | - | LGALS1 | chr22 | 38072993 | + |
| 5CDS-3UTR | ENST00000263246 | ENST00000489315 | PACSIN2 | chr22 | 43272143 | - | LGALS1 | chr22 | 38072993 | + |
| In-frame | ENST00000407585 | ENST00000215909 | PACSIN2 | chr22 | 43272143 | - | LGALS1 | chr22 | 38072993 | + |
| 5CDS-3UTR | ENST00000407585 | ENST00000489315 | PACSIN2 | chr22 | 43272143 | - | LGALS1 | chr22 | 38072993 | + |
| Frame-shift | ENST00000403744 | ENST00000215909 | PACSIN2 | chr22 | 43272143 | - | LGALS1 | chr22 | 38072993 | + |
| 5CDS-3UTR | ENST00000403744 | ENST00000489315 | PACSIN2 | chr22 | 43272143 | - | LGALS1 | chr22 | 38072993 | + |
| In-frame | ENST00000402229 | ENST00000215909 | PACSIN2 | chr22 | 43272143 | - | LGALS1 | chr22 | 38072993 | + |
| 5CDS-3UTR | ENST00000402229 | ENST00000489315 | PACSIN2 | chr22 | 43272143 | - | LGALS1 | chr22 | 38072993 | + |
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FusionProtFeatures for PACSIN2_LGALS1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PACSIN2 | LGALS1 |