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Fusion gene ID: 2571 |
FusionGeneSummary for ARHGEF38_ZNF622 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ARHGEF38_ZNF622 | Fusion gene ID: 2571 | Hgene | Tgene | Gene symbol | ARHGEF38 | ZNF622 | Gene ID | 54848 | 90441 |
| Gene name | Rho guanine nucleotide exchange factor 38 | zinc finger protein 622 | |
| Synonyms | - | ZPR9 | |
| Cytomap | 4q24 | 5p15.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rho guanine nucleotide exchange factor 38Rho guanine nucleotide exchange factor (GEF) 38 | zinc finger protein 622zinc finger-like protein 9 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9NXL2 | Q969S3 | |
| Ensembl transtripts involved in fusion gene | ENST00000420470, ENST00000508036, ENST00000265154, | ENST00000308683, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 4 X 4 X 4=64 |
| # samples | 2 | 4 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ARHGEF38 [Title/Abstract] AND ZNF622 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ZNF622 | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress | 21771788 |
| Tgene | ZNF622 | GO:0033674 | positive regulation of kinase activity | 21771788 |
| Tgene | ZNF622 | GO:0043065 | positive regulation of apoptotic process | 21771788 |
| Tgene | ZNF622 | GO:0043410 | positive regulation of MAPK cascade | 21771788 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-YL-A9WL-01A | ARHGEF38 | chr4 | 106474118 | + | ZNF622 | chr5 | 16463851 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000420470 | ENST00000308683 | ARHGEF38 | chr4 | 106474118 | + | ZNF622 | chr5 | 16463851 | - |
| intron-3CDS | ENST00000508036 | ENST00000308683 | ARHGEF38 | chr4 | 106474118 | + | ZNF622 | chr5 | 16463851 | - |
| In-frame | ENST00000265154 | ENST00000308683 | ARHGEF38 | chr4 | 106474118 | + | ZNF622 | chr5 | 16463851 | - |
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FusionProtFeatures for ARHGEF38_ZNF622 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ARHGEF38 | ZNF622 |