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Fusion gene ID: 25699 |
FusionGeneSummary for P4HB_TPT1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: P4HB_TPT1 | Fusion gene ID: 25699 | Hgene | Tgene | Gene symbol | P4HB | TPT1 | Gene ID | 5034 | 7178 |
| Gene name | prolyl 4-hydroxylase subunit beta | tumor protein, translationally-controlled 1 | |
| Synonyms | CLCRP1|DSI|ERBA2L|GIT|P4Hbeta|PDI|PDIA1|PHDB|PO4DB|PO4HB|PROHB | HRF|TCTP|p02|p23 | |
| Cytomap | 17q25.3 | 13q14.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein disulfide-isomerasecellular thyroid hormone-binding proteincollagen prolyl 4-hydroxylase betaglutathione-insulin transhydrogenasep55procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptideprolyl 4-hydroxyla | translationally-controlled tumor proteinfortilinhistamine-releasing factor | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P07237 | P13693 | |
| Ensembl transtripts involved in fusion gene | ENST00000331483, ENST00000576390, ENST00000439918, ENST00000472244, | ENST00000379056, ENST00000529421, ENST00000530705, ENST00000379060, ENST00000379055, ENST00000309246, | |
| Fusion gene scores | * DoF score | 25 X 9 X 12=2700 | 7 X 10 X 3=210 |
| # samples | 27 | 10 | |
| ** MAII score | log2(27/2700*10)=-3.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/210*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: P4HB [Title/Abstract] AND TPT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | P4HB | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline | 7753822 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-69-8255-01A | P4HB | chr17 | 79801410 | - | TPT1 | chr13 | 45915293 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000331483 | ENST00000379056 | P4HB | chr17 | 79801410 | - | TPT1 | chr13 | 45915293 | - |
| intron-intron | ENST00000331483 | ENST00000529421 | P4HB | chr17 | 79801410 | - | TPT1 | chr13 | 45915293 | - |
| intron-5UTR | ENST00000331483 | ENST00000530705 | P4HB | chr17 | 79801410 | - | TPT1 | chr13 | 45915293 | - |
| intron-intron | ENST00000331483 | ENST00000379060 | P4HB | chr17 | 79801410 | - | TPT1 | chr13 | 45915293 | - |
| intron-intron | ENST00000331483 | ENST00000379055 | P4HB | chr17 | 79801410 | - | TPT1 | chr13 | 45915293 | - |
| intron-intron | ENST00000331483 | ENST00000309246 | P4HB | chr17 | 79801410 | - | TPT1 | chr13 | 45915293 | - |
| intron-5UTR | ENST00000576390 | ENST00000379056 | P4HB | chr17 | 79801410 | - | TPT1 | chr13 | 45915293 | - |
| intron-intron | ENST00000576390 | ENST00000529421 | P4HB | chr17 | 79801410 | - | TPT1 | chr13 | 45915293 | - |
| intron-5UTR | ENST00000576390 | ENST00000530705 | P4HB | chr17 | 79801410 | - | TPT1 | chr13 | 45915293 | - |
| intron-intron | ENST00000576390 | ENST00000379060 | P4HB | chr17 | 79801410 | - | TPT1 | chr13 | 45915293 | - |
| intron-intron | ENST00000576390 | ENST00000379055 | P4HB | chr17 | 79801410 | - | TPT1 | chr13 | 45915293 | - |
| intron-intron | ENST00000576390 | ENST00000309246 | P4HB | chr17 | 79801410 | - | TPT1 | chr13 | 45915293 | - |
| intron-5UTR | ENST00000439918 | ENST00000379056 | P4HB | chr17 | 79801410 | - | TPT1 | chr13 | 45915293 | - |
| intron-intron | ENST00000439918 | ENST00000529421 | P4HB | chr17 | 79801410 | - | TPT1 | chr13 | 45915293 | - |
| intron-5UTR | ENST00000439918 | ENST00000530705 | P4HB | chr17 | 79801410 | - | TPT1 | chr13 | 45915293 | - |
| intron-intron | ENST00000439918 | ENST00000379060 | P4HB | chr17 | 79801410 | - | TPT1 | chr13 | 45915293 | - |
| intron-intron | ENST00000439918 | ENST00000379055 | P4HB | chr17 | 79801410 | - | TPT1 | chr13 | 45915293 | - |
| intron-intron | ENST00000439918 | ENST00000309246 | P4HB | chr17 | 79801410 | - | TPT1 | chr13 | 45915293 | - |
| intron-5UTR | ENST00000472244 | ENST00000379056 | P4HB | chr17 | 79801410 | - | TPT1 | chr13 | 45915293 | - |
| intron-intron | ENST00000472244 | ENST00000529421 | P4HB | chr17 | 79801410 | - | TPT1 | chr13 | 45915293 | - |
| intron-5UTR | ENST00000472244 | ENST00000530705 | P4HB | chr17 | 79801410 | - | TPT1 | chr13 | 45915293 | - |
| intron-intron | ENST00000472244 | ENST00000379060 | P4HB | chr17 | 79801410 | - | TPT1 | chr13 | 45915293 | - |
| intron-intron | ENST00000472244 | ENST00000379055 | P4HB | chr17 | 79801410 | - | TPT1 | chr13 | 45915293 | - |
| intron-intron | ENST00000472244 | ENST00000309246 | P4HB | chr17 | 79801410 | - | TPT1 | chr13 | 45915293 | - |
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FusionProtFeatures for P4HB_TPT1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| P4HB | TPT1 |