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Fusion gene ID: 25634 |
FusionGeneSummary for OTX1_OTX1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: OTX1_OTX1 | Fusion gene ID: 25634 | Hgene | Tgene | Gene symbol | OTX1 | OTX1 | Gene ID | 5013 | 5013 |
| Gene name | orthodenticle homeobox 1 | orthodenticle homeobox 1 | |
| Synonyms | - | - | |
| Cytomap | 2p15 | 2p15 | |
| Type of gene | protein-coding | protein-coding | |
| Description | homeobox protein OTX1orthodenticle homolog 1 | homeobox protein OTX1orthodenticle homolog 1 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | P32242 | P32242 | |
| Ensembl transtripts involved in fusion gene | ENST00000366671, ENST00000282549, | ENST00000366671, ENST00000282549, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 2 X 1=4 |
| # samples | 2 | 6 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(6/4*10)=3.90689059560852 | |
| Context | PubMed: OTX1 [Title/Abstract] AND OTX1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | OTX1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 18849347 |
| Tgene | OTX1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 18849347 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BQ304356 | OTX1 | chr2 | 63283373 | - | OTX1 | chr2 | 63283230 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000366671 | ENST00000366671 | OTX1 | chr2 | 63283373 | - | OTX1 | chr2 | 63283230 | + |
| Frame-shift | ENST00000366671 | ENST00000282549 | OTX1 | chr2 | 63283373 | - | OTX1 | chr2 | 63283230 | + |
| Frame-shift | ENST00000282549 | ENST00000366671 | OTX1 | chr2 | 63283373 | - | OTX1 | chr2 | 63283230 | + |
| Frame-shift | ENST00000282549 | ENST00000282549 | OTX1 | chr2 | 63283373 | - | OTX1 | chr2 | 63283230 | + |
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FusionProtFeatures for OTX1_OTX1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| OTX1 | OTX1 |