|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 25605 |
FusionGeneSummary for OSTC_DDOST |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: OSTC_DDOST | Fusion gene ID: 25605 | Hgene | Tgene | Gene symbol | OSTC | DDOST | Gene ID | 58505 | 1650 |
| Gene name | oligosaccharyltransferase complex non-catalytic subunit | dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit | |
| Synonyms | DC2 | AGER1|CDG1R|GATD6|OKSWcl45|OST|OST48|WBP1 | |
| Cytomap | 4q25 | 1p36.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | oligosaccharyltransferase complex subunit OSTChydrophobic protein HSF-28oligosaccharyltransferase complex subunit (non-catalytic) | dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunitadvanced glycation end-product receptor 1advanced glycation endproduct receptor 1dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)dolichy | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9NRP0 | P39656 | |
| Ensembl transtripts involved in fusion gene | ENST00000361564, ENST00000512478, ENST00000505745, | ENST00000602624, ENST00000375048, ENST00000415136, ENST00000477229, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 6 X 5 X 3=90 |
| # samples | 1 | 7 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(7/90*10)=-0.362570079384708 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: OSTC [Title/Abstract] AND DDOST [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | DDOST | GO:0006487 | protein N-linked glycosylation | 9642163 |
| Tgene | DDOST | GO:0034097 | response to cytokine | 9642163 |
| Tgene | DDOST | GO:0042110 | T cell activation | 9642163 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW614804 | OSTC | chr4 | 109588663 | - | DDOST | chr1 | 20978660 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3UTR | ENST00000361564 | ENST00000602624 | OSTC | chr4 | 109588663 | - | DDOST | chr1 | 20978660 | + |
| 3UTR-3UTR | ENST00000361564 | ENST00000375048 | OSTC | chr4 | 109588663 | - | DDOST | chr1 | 20978660 | + |
| 3UTR-3UTR | ENST00000361564 | ENST00000415136 | OSTC | chr4 | 109588663 | - | DDOST | chr1 | 20978660 | + |
| 3UTR-intron | ENST00000361564 | ENST00000477229 | OSTC | chr4 | 109588663 | - | DDOST | chr1 | 20978660 | + |
| intron-3UTR | ENST00000512478 | ENST00000602624 | OSTC | chr4 | 109588663 | - | DDOST | chr1 | 20978660 | + |
| intron-3UTR | ENST00000512478 | ENST00000375048 | OSTC | chr4 | 109588663 | - | DDOST | chr1 | 20978660 | + |
| intron-3UTR | ENST00000512478 | ENST00000415136 | OSTC | chr4 | 109588663 | - | DDOST | chr1 | 20978660 | + |
| intron-intron | ENST00000512478 | ENST00000477229 | OSTC | chr4 | 109588663 | - | DDOST | chr1 | 20978660 | + |
| intron-3UTR | ENST00000505745 | ENST00000602624 | OSTC | chr4 | 109588663 | - | DDOST | chr1 | 20978660 | + |
| intron-3UTR | ENST00000505745 | ENST00000375048 | OSTC | chr4 | 109588663 | - | DDOST | chr1 | 20978660 | + |
| intron-3UTR | ENST00000505745 | ENST00000415136 | OSTC | chr4 | 109588663 | - | DDOST | chr1 | 20978660 | + |
| intron-intron | ENST00000505745 | ENST00000477229 | OSTC | chr4 | 109588663 | - | DDOST | chr1 | 20978660 | + |
Top |
FusionProtFeatures for OSTC_DDOST |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| OSTC | DDOST |