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Fusion gene ID: 25599

FusionGeneSummary for OSGIN2_DECR1

Fusion gene summary

Fusion gene information	Fusion gene name: OSGIN2_DECR1
	Fusion gene ID: 25599
		Hgene	Tgene
	Gene symbol	OSGIN2	DECR1
	Gene ID	734	1666
	Gene name	oxidative stress induced growth inhibitor family member 2	2,4-dienoyl-CoA reductase 1
	Synonyms	C8orf1\|hT41	DECR\|NADPH\|SDR18C1
	Cytomap	8q21.3	8q21.3
	Type of gene	protein-coding	protein-coding
	Description	oxidative stress-induced growth inhibitor 2	2,4-dienoyl-CoA reductase, mitochondrial2,4-dienoyl-CoA reductase 1, mitochondrial4-enoyl-CoA reductaseshort chain dehydrogenase/reductase family 18C member 1
	Modification date	20180523	20180519
	UniProtAcc	Q9Y236	Q16698
	Ensembl transtripts involved in fusion gene	ENST00000297438, ENST00000451899, ENST00000520659,	ENST00000220764, ENST00000519007, ENST00000522161,
Fusion gene scores	* DoF score	2 X 3 X 5=30	5 X 5 X 7=175
	# samples	6	8
	** MAII score	log2(6/30*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(8/175*10)=-1.12928301694497 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: OSGIN2 [Title/Abstract] AND DECR1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	DECR1	GO:0006635	fatty acid beta-oxidation	15531764
Tgene	DECR1	GO:0051289	protein homotetramerization	15531764

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	BLCA	TCGA-XF-A9T5-01A	OSGIN2	chr8	90933399	+	DECR1	chr8	91054956	+
TCGA	LD	BRCA	TCGA-GI-A2C9-01A	OSGIN2	chr8	90926974	+	DECR1	chr8	91029352	+
TCGA	LD	KIRC	TCGA-A3-3335-01A	OSGIN2	chr8	90921949	+	DECR1	chr8	91029352	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000297438	ENST00000220764	OSGIN2	chr8	90933399	+	DECR1	chr8	91054956	+
5CDS-intron	ENST00000297438	ENST00000519007	OSGIN2	chr8	90933399	+	DECR1	chr8	91054956	+
5CDS-intron	ENST00000297438	ENST00000522161	OSGIN2	chr8	90933399	+	DECR1	chr8	91054956	+
In-frame	ENST00000451899	ENST00000220764	OSGIN2	chr8	90933399	+	DECR1	chr8	91054956	+
5CDS-intron	ENST00000451899	ENST00000519007	OSGIN2	chr8	90933399	+	DECR1	chr8	91054956	+
5CDS-intron	ENST00000451899	ENST00000522161	OSGIN2	chr8	90933399	+	DECR1	chr8	91054956	+
Frame-shift	ENST00000520659	ENST00000220764	OSGIN2	chr8	90933399	+	DECR1	chr8	91054956	+
5CDS-intron	ENST00000520659	ENST00000519007	OSGIN2	chr8	90933399	+	DECR1	chr8	91054956	+
5CDS-intron	ENST00000520659	ENST00000522161	OSGIN2	chr8	90933399	+	DECR1	chr8	91054956	+
In-frame	ENST00000297438	ENST00000220764	OSGIN2	chr8	90926974	+	DECR1	chr8	91029352	+
5CDS-3UTR	ENST00000297438	ENST00000519007	OSGIN2	chr8	90926974	+	DECR1	chr8	91029352	+
5CDS-3UTR	ENST00000297438	ENST00000522161	OSGIN2	chr8	90926974	+	DECR1	chr8	91029352	+
In-frame	ENST00000451899	ENST00000220764	OSGIN2	chr8	90926974	+	DECR1	chr8	91029352	+
5CDS-3UTR	ENST00000451899	ENST00000519007	OSGIN2	chr8	90926974	+	DECR1	chr8	91029352	+
5CDS-3UTR	ENST00000451899	ENST00000522161	OSGIN2	chr8	90926974	+	DECR1	chr8	91029352	+
In-frame	ENST00000520659	ENST00000220764	OSGIN2	chr8	90926974	+	DECR1	chr8	91029352	+
5CDS-3UTR	ENST00000520659	ENST00000519007	OSGIN2	chr8	90926974	+	DECR1	chr8	91029352	+
5CDS-3UTR	ENST00000520659	ENST00000522161	OSGIN2	chr8	90926974	+	DECR1	chr8	91029352	+
Frame-shift	ENST00000297438	ENST00000220764	OSGIN2	chr8	90921949	+	DECR1	chr8	91029352	+
5CDS-3UTR	ENST00000297438	ENST00000519007	OSGIN2	chr8	90921949	+	DECR1	chr8	91029352	+
5CDS-3UTR	ENST00000297438	ENST00000522161	OSGIN2	chr8	90921949	+	DECR1	chr8	91029352	+
Frame-shift	ENST00000451899	ENST00000220764	OSGIN2	chr8	90921949	+	DECR1	chr8	91029352	+
5CDS-3UTR	ENST00000451899	ENST00000519007	OSGIN2	chr8	90921949	+	DECR1	chr8	91029352	+
5CDS-3UTR	ENST00000451899	ENST00000522161	OSGIN2	chr8	90921949	+	DECR1	chr8	91029352	+
Frame-shift	ENST00000520659	ENST00000220764	OSGIN2	chr8	90921949	+	DECR1	chr8	91029352	+
5CDS-3UTR	ENST00000520659	ENST00000519007	OSGIN2	chr8	90921949	+	DECR1	chr8	91029352	+
5CDS-3UTR	ENST00000520659	ENST00000522161	OSGIN2	chr8	90921949	+	DECR1	chr8	91029352	+

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FusionProtFeatures for OSGIN2_DECR1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
OSGIN2 Q9Y236	DECR1 Q16698

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Fusion gene ID: 25599

FusionGeneSummary for OSGIN2_DECR1

FusionProtFeatures for OSGIN2_DECR1