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Fusion gene ID: 2559 |
FusionGeneSummary for ARHGEF2_CCT3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ARHGEF2_CCT3 | Fusion gene ID: 2559 | Hgene | Tgene | Gene symbol | ARHGEF2 | CCT3 | Gene ID | 9181 | 7203 |
| Gene name | Rho/Rac guanine nucleotide exchange factor 2 | chaperonin containing TCP1 subunit 3 | |
| Synonyms | GEF|GEF-H1|GEFH1|LFP40|NEDMHM|P40 | CCT-gamma|CCTG|PIG48|TCP-1-gamma|TRIC5 | |
| Cytomap | 1q22 | 1q22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rho guanine nucleotide exchange factor 2Rho/Rac guanine nucleotide exchange factor (GEF) 2guanine nucleotide exchange factor H1microtubule-regulated Rho-GEFproliferating cell nucleolar antigen p40 | T-complex protein 1 subunit gammaT-complex protein 1, gamma subunitTCP1 (t-complex-1) ring complex, polypeptide 5chaperonin containing TCP1, subunit 3 (gamma)hTRiC5 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q92974 | P49368 | |
| Ensembl transtripts involved in fusion gene | ENST00000368315, ENST00000313695, ENST00000361247, ENST00000368316, ENST00000462460, ENST00000477754, ENST00000313667, | ENST00000295688, ENST00000368259, ENST00000368261, ENST00000472765, ENST00000368256, | |
| Fusion gene scores | * DoF score | 9 X 8 X 9=648 | 12 X 8 X 9=864 |
| # samples | 10 | 12 | |
| ** MAII score | log2(10/648*10)=-2.6959938131099 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/864*10)=-2.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ARHGEF2 [Title/Abstract] AND CCT3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ARHGEF2 | GO:0032755 | positive regulation of interleukin-6 production | 21887730 |
| Hgene | ARHGEF2 | GO:0032760 | positive regulation of tumor necrosis factor production | 21887730 |
| Hgene | ARHGEF2 | GO:0045666 | positive regulation of neuron differentiation | 28453519 |
| Hgene | ARHGEF2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 21887730 |
| Hgene | ARHGEF2 | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 21887730 |
| Hgene | ARHGEF2 | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 19043560|21887730 |
| Hgene | ARHGEF2 | GO:0055059 | asymmetric neuroblast division | 28453519 |
| Hgene | ARHGEF2 | GO:0071225 | cellular response to muramyl dipeptide | 21887730 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-R5-A7ZE-01B | ARHGEF2 | chr1 | 155924693 | - | CCT3 | chr1 | 156305679 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000368315 | ENST00000295688 | ARHGEF2 | chr1 | 155924693 | - | CCT3 | chr1 | 156305679 | - |
| In-frame | ENST00000368315 | ENST00000368259 | ARHGEF2 | chr1 | 155924693 | - | CCT3 | chr1 | 156305679 | - |
| 5CDS-5UTR | ENST00000368315 | ENST00000368261 | ARHGEF2 | chr1 | 155924693 | - | CCT3 | chr1 | 156305679 | - |
| 5CDS-5UTR | ENST00000368315 | ENST00000472765 | ARHGEF2 | chr1 | 155924693 | - | CCT3 | chr1 | 156305679 | - |
| 5CDS-5UTR | ENST00000368315 | ENST00000368256 | ARHGEF2 | chr1 | 155924693 | - | CCT3 | chr1 | 156305679 | - |
| In-frame | ENST00000313695 | ENST00000295688 | ARHGEF2 | chr1 | 155924693 | - | CCT3 | chr1 | 156305679 | - |
| In-frame | ENST00000313695 | ENST00000368259 | ARHGEF2 | chr1 | 155924693 | - | CCT3 | chr1 | 156305679 | - |
| 5CDS-5UTR | ENST00000313695 | ENST00000368261 | ARHGEF2 | chr1 | 155924693 | - | CCT3 | chr1 | 156305679 | - |
| 5CDS-5UTR | ENST00000313695 | ENST00000472765 | ARHGEF2 | chr1 | 155924693 | - | CCT3 | chr1 | 156305679 | - |
| 5CDS-5UTR | ENST00000313695 | ENST00000368256 | ARHGEF2 | chr1 | 155924693 | - | CCT3 | chr1 | 156305679 | - |
| In-frame | ENST00000361247 | ENST00000295688 | ARHGEF2 | chr1 | 155924693 | - | CCT3 | chr1 | 156305679 | - |
| In-frame | ENST00000361247 | ENST00000368259 | ARHGEF2 | chr1 | 155924693 | - | CCT3 | chr1 | 156305679 | - |
| 5CDS-5UTR | ENST00000361247 | ENST00000368261 | ARHGEF2 | chr1 | 155924693 | - | CCT3 | chr1 | 156305679 | - |
| 5CDS-5UTR | ENST00000361247 | ENST00000472765 | ARHGEF2 | chr1 | 155924693 | - | CCT3 | chr1 | 156305679 | - |
| 5CDS-5UTR | ENST00000361247 | ENST00000368256 | ARHGEF2 | chr1 | 155924693 | - | CCT3 | chr1 | 156305679 | - |
| Frame-shift | ENST00000368316 | ENST00000295688 | ARHGEF2 | chr1 | 155924693 | - | CCT3 | chr1 | 156305679 | - |
| Frame-shift | ENST00000368316 | ENST00000368259 | ARHGEF2 | chr1 | 155924693 | - | CCT3 | chr1 | 156305679 | - |
| 5CDS-5UTR | ENST00000368316 | ENST00000368261 | ARHGEF2 | chr1 | 155924693 | - | CCT3 | chr1 | 156305679 | - |
| 5CDS-5UTR | ENST00000368316 | ENST00000472765 | ARHGEF2 | chr1 | 155924693 | - | CCT3 | chr1 | 156305679 | - |
| 5CDS-5UTR | ENST00000368316 | ENST00000368256 | ARHGEF2 | chr1 | 155924693 | - | CCT3 | chr1 | 156305679 | - |
| Frame-shift | ENST00000462460 | ENST00000295688 | ARHGEF2 | chr1 | 155924693 | - | CCT3 | chr1 | 156305679 | - |
| Frame-shift | ENST00000462460 | ENST00000368259 | ARHGEF2 | chr1 | 155924693 | - | CCT3 | chr1 | 156305679 | - |
| 5CDS-5UTR | ENST00000462460 | ENST00000368261 | ARHGEF2 | chr1 | 155924693 | - | CCT3 | chr1 | 156305679 | - |
| 5CDS-5UTR | ENST00000462460 | ENST00000472765 | ARHGEF2 | chr1 | 155924693 | - | CCT3 | chr1 | 156305679 | - |
| 5CDS-5UTR | ENST00000462460 | ENST00000368256 | ARHGEF2 | chr1 | 155924693 | - | CCT3 | chr1 | 156305679 | - |
| intron-3CDS | ENST00000477754 | ENST00000295688 | ARHGEF2 | chr1 | 155924693 | - | CCT3 | chr1 | 156305679 | - |
| intron-3CDS | ENST00000477754 | ENST00000368259 | ARHGEF2 | chr1 | 155924693 | - | CCT3 | chr1 | 156305679 | - |
| intron-5UTR | ENST00000477754 | ENST00000368261 | ARHGEF2 | chr1 | 155924693 | - | CCT3 | chr1 | 156305679 | - |
| intron-5UTR | ENST00000477754 | ENST00000472765 | ARHGEF2 | chr1 | 155924693 | - | CCT3 | chr1 | 156305679 | - |
| intron-5UTR | ENST00000477754 | ENST00000368256 | ARHGEF2 | chr1 | 155924693 | - | CCT3 | chr1 | 156305679 | - |
| In-frame | ENST00000313667 | ENST00000295688 | ARHGEF2 | chr1 | 155924693 | - | CCT3 | chr1 | 156305679 | - |
| In-frame | ENST00000313667 | ENST00000368259 | ARHGEF2 | chr1 | 155924693 | - | CCT3 | chr1 | 156305679 | - |
| 5CDS-5UTR | ENST00000313667 | ENST00000368261 | ARHGEF2 | chr1 | 155924693 | - | CCT3 | chr1 | 156305679 | - |
| 5CDS-5UTR | ENST00000313667 | ENST00000472765 | ARHGEF2 | chr1 | 155924693 | - | CCT3 | chr1 | 156305679 | - |
| 5CDS-5UTR | ENST00000313667 | ENST00000368256 | ARHGEF2 | chr1 | 155924693 | - | CCT3 | chr1 | 156305679 | - |
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FusionProtFeatures for ARHGEF2_CCT3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ARHGEF2 | CCT3 |