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Fusion gene ID: 25587 |
FusionGeneSummary for OSBP_GAL |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: OSBP_GAL | Fusion gene ID: 25587 | Hgene | Tgene | Gene symbol | OSBP | GAL | Gene ID | 5007 | 51083 |
| Gene name | oxysterol binding protein | galanin and GMAP prepropeptide | |
| Synonyms | OSBP1 | ETL8|GAL-GMAP|GALN|GLNN|GMAP | |
| Cytomap | 11q12.1 | 11q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | oxysterol-binding protein 1 | galanin peptidesgalanin prepropeptidegalanin-message-associated peptidegalanin-related peptidegalanin/GMAP prepropeptide | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P22059 | P22466 | |
| Ensembl transtripts involved in fusion gene | ENST00000263847, | ENST00000538401, ENST00000265643, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 4 X 3 X 4=48 |
| # samples | 3 | 4 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: OSBP [Title/Abstract] AND GAL [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | OSBP | GO:0015918 | sterol transport | 24209621 |
| Tgene | GAL | GO:0010737 | protein kinase A signaling | 17982695 |
| Tgene | GAL | GO:0019933 | cAMP-mediated signaling | 17982695 |
| Tgene | GAL | GO:0045944 | positive regulation of transcription by RNA polymerase II | 24517231 |
| Tgene | GAL | GO:0051464 | positive regulation of cortisol secretion | 17982695 |
| Tgene | GAL | GO:0051795 | positive regulation of timing of catagen | 22329353 |
| Tgene | GAL | GO:1902608 | positive regulation of large conductance calcium-activated potassium channel activity | 24602615 |
| Tgene | GAL | GO:1902891 | negative regulation of root hair elongation | 22329353 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A8-A06N-01A | OSBP | chr11 | 59375957 | - | GAL | chr11 | 68458385 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000263847 | ENST00000538401 | OSBP | chr11 | 59375957 | - | GAL | chr11 | 68458385 | + |
| 5CDS-intron | ENST00000263847 | ENST00000265643 | OSBP | chr11 | 59375957 | - | GAL | chr11 | 68458385 | + |
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FusionProtFeatures for OSBP_GAL |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| OSBP | GAL |