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Fusion gene ID: 25579

FusionGeneSummary for OSBPL9_C1orf87

Fusion gene summary

Fusion gene information	Fusion gene name: OSBPL9_C1orf87
	Fusion gene ID: 25579
		Hgene	Tgene
	Gene symbol	OSBPL9	C1orf87
	Gene ID	114883	127795
	Gene name	oxysterol binding protein like 9	chromosome 1 open reading frame 87
	Synonyms	ORP-9\|ORP9	CREF
	Cytomap	1p32.3	1p32.1
	Type of gene	protein-coding	protein-coding
	Description	oxysterol-binding protein-related protein 9OSBP-related protein 9	uncharacterized protein C1orf87carcinoma-related EF-hand protein
	Modification date	20180523	20180519
	UniProtAcc	Q96SU4	Q8N0U7
	Ensembl transtripts involved in fusion gene	ENST00000371714, ENST00000371710, ENST00000337809, ENST00000435686, ENST00000447887, ENST00000453295, ENST00000428468, ENST00000530544, ENST00000531828, ENST00000361556, ENST00000473207, ENST00000462759, ENST00000486942,	ENST00000486478, ENST00000450089, ENST00000371201, ENST00000395552,
Fusion gene scores	* DoF score	10 X 8 X 6=480	5 X 5 X 5=125
	# samples	12	5
	** MAII score	log2(12/480*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/125*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: OSBPL9 [Title/Abstract] AND C1orf87 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	BRCA	TCGA-E9-A1R7-01A	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000371714	ENST00000486478	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
5CDS-intron	ENST00000371714	ENST00000450089	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
5CDS-intron	ENST00000371714	ENST00000371201	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
5CDS-intron	ENST00000371714	ENST00000395552	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
5CDS-intron	ENST00000371710	ENST00000486478	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
5CDS-intron	ENST00000371710	ENST00000450089	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
5CDS-intron	ENST00000371710	ENST00000371201	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
5CDS-intron	ENST00000371710	ENST00000395552	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
5CDS-intron	ENST00000337809	ENST00000486478	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
5CDS-intron	ENST00000337809	ENST00000450089	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
5CDS-intron	ENST00000337809	ENST00000371201	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
5CDS-intron	ENST00000337809	ENST00000395552	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
5UTR-intron	ENST00000435686	ENST00000486478	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
5UTR-intron	ENST00000435686	ENST00000450089	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
5UTR-intron	ENST00000435686	ENST00000371201	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
5UTR-intron	ENST00000435686	ENST00000395552	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
5CDS-intron	ENST00000447887	ENST00000486478	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
5CDS-intron	ENST00000447887	ENST00000450089	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
5CDS-intron	ENST00000447887	ENST00000371201	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
5CDS-intron	ENST00000447887	ENST00000395552	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
intron-intron	ENST00000453295	ENST00000486478	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
intron-intron	ENST00000453295	ENST00000450089	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
intron-intron	ENST00000453295	ENST00000371201	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
intron-intron	ENST00000453295	ENST00000395552	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
5CDS-intron	ENST00000428468	ENST00000486478	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
5CDS-intron	ENST00000428468	ENST00000450089	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
5CDS-intron	ENST00000428468	ENST00000371201	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
5CDS-intron	ENST00000428468	ENST00000395552	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
intron-intron	ENST00000530544	ENST00000486478	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
intron-intron	ENST00000530544	ENST00000450089	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
intron-intron	ENST00000530544	ENST00000371201	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
intron-intron	ENST00000530544	ENST00000395552	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
intron-intron	ENST00000531828	ENST00000486478	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
intron-intron	ENST00000531828	ENST00000450089	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
intron-intron	ENST00000531828	ENST00000371201	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
intron-intron	ENST00000531828	ENST00000395552	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
intron-intron	ENST00000361556	ENST00000486478	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
intron-intron	ENST00000361556	ENST00000450089	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
intron-intron	ENST00000361556	ENST00000371201	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
intron-intron	ENST00000361556	ENST00000395552	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
intron-intron	ENST00000473207	ENST00000486478	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
intron-intron	ENST00000473207	ENST00000450089	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
intron-intron	ENST00000473207	ENST00000371201	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
intron-intron	ENST00000473207	ENST00000395552	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
intron-intron	ENST00000462759	ENST00000486478	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
intron-intron	ENST00000462759	ENST00000450089	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
intron-intron	ENST00000462759	ENST00000371201	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
intron-intron	ENST00000462759	ENST00000395552	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
intron-intron	ENST00000486942	ENST00000486478	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
intron-intron	ENST00000486942	ENST00000450089	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
intron-intron	ENST00000486942	ENST00000371201	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-
intron-intron	ENST00000486942	ENST00000395552	OSBPL9	chr1	52117713	+	C1orf87	chr1	60476128	-

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FusionProtFeatures for OSBPL9_C1orf87

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
OSBPL9 Q96SU4	C1orf87 Q8N0U7

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Fusion gene ID: 25579

FusionGeneSummary for OSBPL9_C1orf87

FusionProtFeatures for OSBPL9_C1orf87