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Fusion gene ID: 25561 |
FusionGeneSummary for OSBPL8_ACSS3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: OSBPL8_ACSS3 | Fusion gene ID: 25561 | Hgene | Tgene | Gene symbol | OSBPL8 | ACSS3 | Gene ID | 114882 | 79611 |
| Gene name | oxysterol binding protein like 8 | acyl-CoA synthetase short chain family member 3 | |
| Synonyms | MST120|MSTP120|ORP8|OSBP10 | - | |
| Cytomap | 12q21.2 | 12q21.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | oxysterol-binding protein-related protein 8OSBP-related protein 8 | acyl-CoA synthetase short-chain family member 3, mitochondrialAMP-binding enzyme, 33217 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9BZF1 | Q9H6R3 | |
| Ensembl transtripts involved in fusion gene | ENST00000393249, ENST00000261183, ENST00000393250, ENST00000552178, | ENST00000548058, ENST00000261206, ENST00000548324, | |
| Fusion gene scores | * DoF score | 16 X 5 X 5=400 | 15 X 10 X 7=1050 |
| # samples | 13 | 11 | |
| ** MAII score | log2(13/400*10)=-1.62148837674627 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/1050*10)=-3.25481389902883 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: OSBPL8 [Title/Abstract] AND ACSS3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | OSBPL8 | GO:0010891 | negative regulation of sequestering of triglyceride | 23028956 |
| Hgene | OSBPL8 | GO:0015914 | phospholipid transport | 26206935 |
| Hgene | OSBPL8 | GO:0045444 | fat cell differentiation | 23028956 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-33-4587-01A | OSBPL8 | chr12 | 76844631 | - | ACSS3 | chr12 | 81503339 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000393249 | ENST00000548058 | OSBPL8 | chr12 | 76844631 | - | ACSS3 | chr12 | 81503339 | + |
| Frame-shift | ENST00000393249 | ENST00000261206 | OSBPL8 | chr12 | 76844631 | - | ACSS3 | chr12 | 81503339 | + |
| 5CDS-intron | ENST00000393249 | ENST00000548324 | OSBPL8 | chr12 | 76844631 | - | ACSS3 | chr12 | 81503339 | + |
| Frame-shift | ENST00000261183 | ENST00000548058 | OSBPL8 | chr12 | 76844631 | - | ACSS3 | chr12 | 81503339 | + |
| Frame-shift | ENST00000261183 | ENST00000261206 | OSBPL8 | chr12 | 76844631 | - | ACSS3 | chr12 | 81503339 | + |
| 5CDS-intron | ENST00000261183 | ENST00000548324 | OSBPL8 | chr12 | 76844631 | - | ACSS3 | chr12 | 81503339 | + |
| In-frame | ENST00000393250 | ENST00000548058 | OSBPL8 | chr12 | 76844631 | - | ACSS3 | chr12 | 81503339 | + |
| In-frame | ENST00000393250 | ENST00000261206 | OSBPL8 | chr12 | 76844631 | - | ACSS3 | chr12 | 81503339 | + |
| 5CDS-intron | ENST00000393250 | ENST00000548324 | OSBPL8 | chr12 | 76844631 | - | ACSS3 | chr12 | 81503339 | + |
| intron-3CDS | ENST00000552178 | ENST00000548058 | OSBPL8 | chr12 | 76844631 | - | ACSS3 | chr12 | 81503339 | + |
| intron-3CDS | ENST00000552178 | ENST00000261206 | OSBPL8 | chr12 | 76844631 | - | ACSS3 | chr12 | 81503339 | + |
| intron-intron | ENST00000552178 | ENST00000548324 | OSBPL8 | chr12 | 76844631 | - | ACSS3 | chr12 | 81503339 | + |
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FusionProtFeatures for OSBPL8_ACSS3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| OSBPL8 | ACSS3 |