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Fusion gene ID: 25529

FusionGeneSummary for OSBPL1A_MYO16

Fusion gene summary

Fusion gene information	Fusion gene name: OSBPL1A_MYO16
	Fusion gene ID: 25529
		Hgene	Tgene
	Gene symbol	OSBPL1A	MYO16
	Gene ID	114876	23026
	Gene name	oxysterol binding protein like 1A	myosin XVI
	Synonyms	ORP-1\|ORP1\|OSBPL1B	MYAP3\|MYR8\|Myo16b\|NYAP3\|PPP1R107
	Cytomap	18q11.2	13q33.3
	Type of gene	protein-coding	protein-coding
	Description	oxysterol-binding protein-related protein 1OSBP-related protein 1oxysterol binding protein-like 1Boxysterol-binding protein-related protein 1 variant 1oxysterol-binding protein-related protein 1 variant 2	unconventional myosin-XVIMYO16 variant proteinmyosin heavy chain Myr 8neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 3protein phosphatase 1, regulatory subunit 10
	Modification date	20180523	20180519
	UniProtAcc	Q9BXW6	Q9Y6X6
	Ensembl transtripts involved in fusion gene	ENST00000319481, ENST00000399443, ENST00000357041, ENST00000399441, ENST00000582618,	ENST00000356711, ENST00000251041, ENST00000357550, ENST00000457511, ENST00000467639,
Fusion gene scores	* DoF score	8 X 6 X 6=288	10 X 8 X 9=720
	# samples	7	10
	** MAII score	log2(7/288*10)=-2.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/720*10)=-2.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: OSBPL1A [Title/Abstract] AND MYO16 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	HNSC	TCGA-T3-A92M-01A	OSBPL1A	chr18	21819184	-	MYO16	chr13	109772718	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000319481	ENST00000356711	OSBPL1A	chr18	21819184	-	MYO16	chr13	109772718	+
5CDS-intron	ENST00000319481	ENST00000251041	OSBPL1A	chr18	21819184	-	MYO16	chr13	109772718	+
5CDS-intron	ENST00000319481	ENST00000357550	OSBPL1A	chr18	21819184	-	MYO16	chr13	109772718	+
5CDS-intron	ENST00000319481	ENST00000457511	OSBPL1A	chr18	21819184	-	MYO16	chr13	109772718	+
5CDS-intron	ENST00000319481	ENST00000467639	OSBPL1A	chr18	21819184	-	MYO16	chr13	109772718	+
5UTR-3CDS	ENST00000399443	ENST00000356711	OSBPL1A	chr18	21819184	-	MYO16	chr13	109772718	+
5UTR-intron	ENST00000399443	ENST00000251041	OSBPL1A	chr18	21819184	-	MYO16	chr13	109772718	+
5UTR-intron	ENST00000399443	ENST00000357550	OSBPL1A	chr18	21819184	-	MYO16	chr13	109772718	+
5UTR-intron	ENST00000399443	ENST00000457511	OSBPL1A	chr18	21819184	-	MYO16	chr13	109772718	+
5UTR-intron	ENST00000399443	ENST00000467639	OSBPL1A	chr18	21819184	-	MYO16	chr13	109772718	+
In-frame	ENST00000357041	ENST00000356711	OSBPL1A	chr18	21819184	-	MYO16	chr13	109772718	+
5CDS-intron	ENST00000357041	ENST00000251041	OSBPL1A	chr18	21819184	-	MYO16	chr13	109772718	+
5CDS-intron	ENST00000357041	ENST00000357550	OSBPL1A	chr18	21819184	-	MYO16	chr13	109772718	+
5CDS-intron	ENST00000357041	ENST00000457511	OSBPL1A	chr18	21819184	-	MYO16	chr13	109772718	+
5CDS-intron	ENST00000357041	ENST00000467639	OSBPL1A	chr18	21819184	-	MYO16	chr13	109772718	+
intron-3CDS	ENST00000399441	ENST00000356711	OSBPL1A	chr18	21819184	-	MYO16	chr13	109772718	+
intron-intron	ENST00000399441	ENST00000251041	OSBPL1A	chr18	21819184	-	MYO16	chr13	109772718	+
intron-intron	ENST00000399441	ENST00000357550	OSBPL1A	chr18	21819184	-	MYO16	chr13	109772718	+
intron-intron	ENST00000399441	ENST00000457511	OSBPL1A	chr18	21819184	-	MYO16	chr13	109772718	+
intron-intron	ENST00000399441	ENST00000467639	OSBPL1A	chr18	21819184	-	MYO16	chr13	109772718	+
intron-3CDS	ENST00000582618	ENST00000356711	OSBPL1A	chr18	21819184	-	MYO16	chr13	109772718	+
intron-intron	ENST00000582618	ENST00000251041	OSBPL1A	chr18	21819184	-	MYO16	chr13	109772718	+
intron-intron	ENST00000582618	ENST00000357550	OSBPL1A	chr18	21819184	-	MYO16	chr13	109772718	+
intron-intron	ENST00000582618	ENST00000457511	OSBPL1A	chr18	21819184	-	MYO16	chr13	109772718	+
intron-intron	ENST00000582618	ENST00000467639	OSBPL1A	chr18	21819184	-	MYO16	chr13	109772718	+

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FusionProtFeatures for OSBPL1A_MYO16

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
OSBPL1A Q9BXW6	MYO16 Q9Y6X6

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Fusion gene ID: 25529

FusionGeneSummary for OSBPL1A_MYO16

FusionProtFeatures for OSBPL1A_MYO16