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Fusion gene ID: 25375 |
FusionGeneSummary for OFCC1_MEGF9 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: OFCC1_MEGF9 | Fusion gene ID: 25375 | Hgene | Tgene | Gene symbol | OFCC1 | MEGF9 | Gene ID | 266553 | 1955 |
| Gene name | orofacial cleft 1 candidate 1 | multiple EGF like domains 9 | |
| Synonyms | MRDS1|Opo | EGFL5 | |
| Cytomap | 6p24.3 | 9q33.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | orofacial cleft 1 candidate gene 1 proteinorofacial clefting chromosomal breakpoint region candidate 1 protein | multiple epidermal growth factor-like domains protein 9EGF-like-domain, multiple 5epidermal growth factor-like protein 5 | |
| Modification date | 20180523 | 20180329 | |
| UniProtAcc | Q8IZS5 | Q9H1U4 | |
| Ensembl transtripts involved in fusion gene | ENST00000316020, ENST00000472329, | ENST00000426959, ENST00000373930, | |
| Fusion gene scores | * DoF score | 3 X 7 X 2=42 | 4 X 4 X 3=48 |
| # samples | 8 | 4 | |
| ** MAII score | log2(8/42*10)=0.929610672108602 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: OFCC1 [Title/Abstract] AND MEGF9 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CV408930 | OFCC1 | chr6 | 9973953 | + | MEGF9 | chr9 | 123474605 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000316020 | ENST00000426959 | OFCC1 | chr6 | 9973953 | + | MEGF9 | chr9 | 123474605 | + |
| intron-intron | ENST00000316020 | ENST00000373930 | OFCC1 | chr6 | 9973953 | + | MEGF9 | chr9 | 123474605 | + |
| intron-intron | ENST00000472329 | ENST00000426959 | OFCC1 | chr6 | 9973953 | + | MEGF9 | chr9 | 123474605 | + |
| intron-intron | ENST00000472329 | ENST00000373930 | OFCC1 | chr6 | 9973953 | + | MEGF9 | chr9 | 123474605 | + |
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FusionProtFeatures for OFCC1_MEGF9 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| OFCC1 | MEGF9 |